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Interplay between oral health and lifestyle factors for cancer risk in rural and urban China:a population-based cohort study

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Journal of the National Cancer Center 2023年第4期3卷 279-285页

作者： Chao Sheng Xi Zhang Ben Liu Henry S Lynn Kexin Chen Hongji Dai Department of Epidemiology and Biostatistics National Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Molecular Cancer Epidemiology of TianjinTianjin Medical University Cancer Institute and HospitalTianjinChina Clinical Research Unit Xin Hua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Biostatistics School of Public HealthFudan UniversityShanghaiChina

Background:Although poor oral health and several lifestyle factors have been found to be associated with cancer risk,their joint relationship has rarely been ***:We prospectively examined the associations of oral health and healthy lifestyle factors with cancer risk among 0.5 million rural and urban residents from the China Kadoorie Biobank(2004-2015).Oral health status was assessed from self-reported baseline questionnaires.A healthy lifestyle index comprising non-smoking,non-drinking,ideal body shape,physical activity and healthy diet was calculated for each participant,and categorized into favorable,intermediate and unfavorable lifestyle *** calculated hazard ratios(HRs)and 95%confidence intervals(CIs)relating oral health and healthy lifestyle index to cancer risk using Cox proportional hazards *** estimated the population attributable risk percent(PAR%)and 95%CIs using multivariate ***:During a median follow-up of 9 years,23,805 new cancer cases were documented,with 52%from rural areas and 48%from urban *** with those with good oral health and favorable lifestyle,participants with poor oral health and unfavorable lifestyle had a higher risk of developing cancer in both rural(adjusted HR,1.55[95%CI,1.39-1.74];P for trendlifestyle index on cancer risk was found in rural residents(P for interaction=0.004)rather than in urban residents(P for interaction=0.973).Assuming poor oral health as an additional risk factor,the PAR%of total cancer increased by 3.0%and 1.1%for participants with intermediate lifestyle and unfavorable lifestyle,***:These findings suggest a joint effect of oral health and common lifestyle factors on cancer *** of healthy lifestyle by integration of good oral health would be beneficial to consider in cancer prevention stra

关键词： Oral health lifestyle factors Cancer risk Rural-urban disparities Cohort study

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The Impact of lifestyle factors on Migraine Frequency and Severity in Neurology

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Journal of Biosciences and Medicines 2024年第7期12卷 301-313页

作者： Oluwatosin B. Iyun Okelue Edwards Okobi Nneka P. Sams Eleni Asfaw Kebede Oboatarhe Blessing Ezie Department of Public Health and Family Medicine University of Cape Town Cape Town South Africa Larkin Community Hospital PSC Miami FL USA College of Health Sciences & Public Policy Walden University Minneapolis MN USA College of Health Sciences Addis Ababa University Addis Ababa Ethiopia Department of Family Medicine University of Benin Benin City Nigeria

Objective: This systematic review examines the impact of lifestyle factors on migraine frequency and severity through a comprehensive analysis of lifestyle factors such as diet, physical activity, sleep patterns, stress, mental health, and environmental influences. Methods: We thoroughly searched Google Scholar, PUBMED, Scopus, and Web of Science databases using keywords related to migraines and lifestyle factors. Keywords incorporated the Boolean operator “and” to narrow search results. Following the PRISMA guidelines, we identified, screened, and evaluated studies for inclusion, resulting in nine studies meeting the eligibility criteria. Results: A total of 4917 records were initially identified from Scopus (2786), PubMed (854), and Web of Science (1277). Following deduplication, 3657 records underwent title screening, with 382 additionally screened by abstract. Ultimately, 88 full-text articles were assessed, resulting in 9 studies meeting eligibility for qualitative synthesis: 7 prospective and 2 retrospective studies. Our findings highlight the multifaceted role of lifestyle factors in migraine pathophysiology and management. Dietary habits, such as high-calorie, high-fat, and gluten-containing diets were linked to migraine triggers. Moderate physical activity showed beneficial effects on migraine management, while intense exercise could exacerbate symptoms. Poor sleep hygiene and insomnia were strongly associated with increased migraine frequency and severity. Chronic stress and poor mental health significantly contributed to migraine exacerbation, with stress management techniques proving beneficial. Environmental factors, including light, sound, weather changes, and allergens, were also identified as significant migraine triggers. Conclusions: Personalized lifestyle modifications, tailored to individual patient profiles, are crucial in managing migraines. Evidence-based recommendations include balanced diets, moderate physical activity, improved sleep hygien

关键词： Migraine lifestyle factors Diet Physical Activity Sleep Patterns Stress Mental Health Environmental factors Neurology

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Exploring the potential impact of nutritionally actionable genetic polymorphisms on idiopathic male infertility:a review of current evidence

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Asian Journal of Andrology 2021年第5期23卷 441-449页

作者： Sinda Mahbouli Charlotte Dupont Yaelle Elfassy Eric Lameignere Rachel Levy FabLife 104 Avenue Albert lerRueil-Malmaison 92500France Sorbonne University Saint Antoine Research CentreINSERM Genetic and Acquired Lipodystrophies TeamReproductive Biology and CECOSAP-HPTenon HospitalParis F-75020France Reproductive Biology and CECOS AP-HPTenon HospitalParis F-75020France

Infertility affects about 15%of the world's *** 40%-50%of infertile couples,a male factor underlies the problem,but in about 50%of these cases,the etiology of male infertility remains *** clinical data show that lifestyle interventions may contribute to male reproductive *** of unhealthy habits is suggested for preserving male fertility;there is growing evidence that most preexisting comorbidities,such as obesity and metabolic syndrome,are highly likely to have an impact on male *** analysis of genetic polymorphisms implicated in metabolic activity represents one of the most exciting areas in the study of genetic causes of male *** these polymorphisms are not directly connected with male infertility,they may have a role in specific conditions associated with it,that is,metabolic disorders and oxidative stress pathway genes that are potentially associated with an increased risk of male infertility due to DNA and cell membrane *** studies have examined the impact of individual genetic differences and gene-diet interactions on male infertility,but their results have not been *** review the current research to identify genetic variants that could be tested to improve the chances of conceiving spontaneously through personalized diet and/or oral vitamin and mineral supplementation,by examining the science of genetic modifiers of dietary factors that affect nutritional status and male fertility.

关键词： energy metabolism genetic polymorphisms idiopathic male infertility lifestyle factors nutrition oxidative stress semen quality

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Dietary and socio-economic factors in relation to Helicobacter pylori re-infection

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World Journal of Gastroenterology 2009年第9期15卷 1119-1125页

作者： Mirosaw Jarosz Ewa Rychlik Magdalena Siuba Wioleta Respondek Magorzata Ryzko-Skiba Iwona Sajór Sylwia Gugaa Tomasz Bazejczyk Janusz Ciok Department of Dietetics and Nutrition in Hospitals with Clinic of Metabolic Diseases and Gastroenterology National Food and Nutrition Institute02-903 WarsawPoland

AIM:To examine if dietary and socio-economic factors contribute to Helicobacter pylori(H pylori)re-infection. METHODS:The population of patients consisted of subjects in whom H pylori infection had been successfully treated in the *** were divided into two groups:Ⅰ-examined group(111 persons with H pylori re-infection)andⅡ-control group(175 persons who had not been re-infected).The respondents were interviewed retrospectively on their dietary habits and socio-economic factors. RESULTS:A statistically significant lower frequency of fermented dairy products(P<0.0001),vegetables (P=0.02),and fruit(P=0.008)consumption was noted among patients with H pylori re-infection as compared to those who had not been re-infected. CONCLUSION:High dietary intake of probiotic bacteria,mainly Lactobacillus,and antioxidants,mainly vitamin C(contained in fruit and vegetables),might decrease the risk of H pylori re-infection.

关键词： Nutrition Probiotics Helicobacter pylori re-infection Vitamin C lifestyle factors

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Physical exercise in the prevention and treatment of Alzheimer’s disease

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Journal of Sport and Health Science 2020年第5期9卷 394-404页

作者： Adrian De la Rosa Gloria Olaso-Gonzalez Coralie Arc-Chagnaud Fernando Millan Andrea Salvador-Pascual Consolacion Garcıa-Lucerga Cristina Blasco-Lafarga Esther Garcia-Dominguez Aitor Carretero Angela G.Correas Jose Vina Mari Carmen Gomez-Cabrera Freshage Research Group Department of PhysiologyFaculty of MedicineUniversity of Valenciaand CIBERFESInsitute of Health Research-INCLIVAValencia 46010Spain INRA UMR866 Muscle dynamics and metabolismUniversity of MontpellierF-34060MontpellierFrance Department of Physiotherapy Faculty of PhysiotherapyUniversity of ValenciaValencia 46010Spain Physical Education and Sports Department University of ValenciaValencia 46010Spain

Dementia is one of the greatest global challenges for health and social care in the 21st ***’s disease(AD),the most common type of dementia,is by no means an inevitable consequence of growing *** lifestyle factors may increase,or reduce,an individual’s risk of developing *** has been written over the ages about the benefits of exercise and physical *** the risk factors associated with AD is a low level of physical *** relationship between physical and mental health was established several years *** this review,we discuss the role of exercise(aerobic and resistance)training as a therapeutic strategy for the treatment and prevention of *** adults who exercise are more likely to maintain *** address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal *** will pay especial attention to the potential role of exercise in the modulation of amyloid b turnover,inflammation,synthesis and release of neurotrophins,and improvements in cerebral blood *** changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias *** interventions that include the adoption of an active lifestyle should be recommended for older populations.

关键词： Aerobic exercise Dementia Exercise training lifestyle factors Multidomain interventions Resistance exercise

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Nonalcoholic steatohepatitis and hepatocellular carcinoma: Beyond the boundaries of the liver

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World Journal of Gastroenterology 2022年第36期28卷 5380-5382页

作者： Tarana Gupta Department of Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia

The burden of non-alcoholic steatohepatitis (NASH) related hepatocellularcarcinoma (HCC) is drawing attention due to the emerging epidemic of obesityand metabolic syndrome and is expected to increase in the near *** medications, air pollutants, and newer genetic mutations are latestconcerns as risk factors for HCC development in patients with NASH. Althoughmolecular signatures are very accurate, they are not cost-effective and cannot beapplied in larger population due to logistic issues. We need multicentric longitudinalstudies including diverse geographical areas to evaluate the complexinterplay of different risk factors and genetics in these patients.

关键词： Non-alcoholic steatohepatitis Hepatocellular carcinoma Cirrhosis Genetic factors lifestyle factors Surveillance

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lifestyle: an underrated but potentially important influencing factor on semen quality

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Clinical Research Communications 2023年第3期6卷 16-21页

作者： Wen-Kang Chen He-De Zou Han-Fei Liu Bo-Lin Li Jia-You Zhao Graduate School China Academy of Chinese Medical SciencesBeijing 100700China Graduate School Hebei University of Chinese MedicineShijiazhuang 050200China

lifestyle factors play a crucial role in the influence of semen quality,and they are especially significant in the context of traditional Chinese medicine(TCM)clinical treatment for poor semen *** theory emphasizes the importance of healthy lifestyle habits for overall ***,it is essential to consider lifestyle factors in the clinical management of TCM and semen *** can act as a bias factor that affects research quality,making it vital to pay special attention to its impact in clinical trial research on male semen *** article aims to improve the quality and design of clinical research on male sperm quality by examining the effects of various lifestyle factors on semen quality,including physical activities,dietary patterns,smoking,alcohol consumption,coffee intake,sleep,and psychological *** lifestyle factor has its own distinct influence on semen quality,and there is a synergistic effect when multiple lifestyle factors are *** findings emphasize the need for careful consideration of lifestyle factors and their interactions in the design and implementation of TCM clinical trial research.

关键词： lifestyle factors semen quality traditional Chinese medicine clinical trial research synergistic effect

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Modifiable factors mediating the effects of educational attainment on gestational diabetes mellitus: A two-step Mendelian randomization study

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World Journal of Clinical Cases 2024年第26期12卷 5937-5945页

作者： Ming-Yue Ma Ya-Song Zhao Department of Nursing Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Although there is currently a wealth of evidence to indicate that maternal educational attainment is associated with gestational diabetes mellitus(GDM),the specific modifiable risk factors that mediate the causal relationship between these two variables have yet to be *** To identify the specific modifiable risk factors that mediate the causal relationship between the level of maternal education and *** Mendelian randomization(MR)was conducted using data from genome-wide association studies of European *** initially performed a two-sample MR analysis using data on genetic variants associated with the duration of education as instruments,and subsequently adopted a two-step MR approach using metabolic and lifestyle factors as mediators to examine the mechanisms underlying the relationship between the level of maternal education and risk of developing *** addition,we calculated the proportions of total causal effects mediated by identified metabolic and lifestyle *** A genetically predicted higher educational attainment was found to be associated with a lower risk of developing GDM(OR:0.71,95%CI:0.60-0.84).Among the metabolic factors assessed,four emerged as potential mediators of the education-GDM association,which,ranked by mediated proportions,were as follows:Waist-to-hip-ratio(31.56%,95%CI:12.38%-50.70%),body mass index(19.20%,95%CI:12.03%-26.42%),high-density lipoprotein cholesterol(12.81%,95%CI:8.65%-17.05%),and apolipoprotein A-1(7.70%,95%CI:4.32%-11.05%).These findings proved to be robust to sensitivity *** Our findings indicate a causal relationship between lower levels of maternal education and the risk of developing GDM can be partly explained by adverse metabolic profiles.

关键词： Educational status Gestational diabetes mellitus Metabolism lifestyle factors Mendelian randomization analysis

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Why Tibb is:a science of medicine,the art of care

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History & Philosophy of Medicine 2022年第2期4卷 7-10页

作者： Rashid Bhikha Ibn Sina Institute of Tibb JohannesburgSouth Africa

Tibb also known as Unani-Tibb,Greco-Arab,Western Holistic,Unani and Persian medicine,is an ancient holistic medical system that originated approximately 10000 years ago,based on the humoral and temperamental theories that was hypothesised by Hippocrates and ***“completeness”of this medical discipline as“a science of medicine-the art of care”was greatly influenced by renowned scholars including Ibn Sina during the 9th and 13th century,who refined the philosophical principles of;physis,temperament,humours,and the six lifestyle factors,of which physis,the body’s natural ability to heal itself,is a primary principle in the maintenance and restoration of *** as“a science of medicine”is detailed within the context of Ibn Sina’s principle of cause and effect and the“art of care”is highlighted in the holistic and fully integrative approach of Tibb,based on its philosophical *** paper concludes with a brief comparison between Tibb and Western medicine.

关键词： Tibb physis temperament humours lifestyle factors cause and effect

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Exposure to Hyaluronan and Radon-Containing Water during the Treatment of Periodontal Pockets

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Journal of Biosciences and Medicines 2023年第12期11卷 203-217页

作者： Ani Gibishvili Mamuka Gogiberidze Marina Nikolaishvili Beritashvili Biomedicine Center Ivane Javakhishvili Tbilisi State University Tbilisi Georgia

Hyaluronic acid (HA) preparations have emerged as pivotal components in contemporary dentistry, gaining widespread recognition for their multifaceted roles in various biological functions. Extensive literature underscores the significance of HA in maintaining tissue water balance, fostering cell proliferation, promoting rapid cell migration, influencing cell differentiation during organism development, and facilitating tissue regeneration. Notably, HA’s interactions with cell surface receptors contribute to the viscosity of synovial fluid, activate the immune system, and enhance cartilage elasticity. Beyond these established functions, HA has also been investigated for its potential involvement in determining and studying the hormetic effects of radon water, adding a novel dimension to its applications in dental research. A thorough exploration of existing studies reveals a nuanced understanding of how HA interventions impact the outcomes of dental procedures. The comprehensive scope of these investigations allows for a more accurate assessment of the potential effectiveness of specific interventions and provides valuable insights into post-procedural prognoses for individual patients. This synthesis of literature serves as the foundation for elucidating the intricate interplay between HA, radon exposure, and their relevance in modern dental practices.

关键词： Hyaluronic Acid Dental Practice Biological Functions Tissue Water Balance Cell Proliferation Cell Migration Cell Differentiation Tissue Regeneration Synovial Fluid Viscosity Immune System Activation Cartilage Elasticity Radon Water Hormetic Effects Dental Research Intervention Effectiveness Post-Procedural Prognosis Risk factors Inflammatory Periodontal Diseases Chronic Somatic Diseases Gastrointestinal Tract Disorders Respiratory Susceptibility Hereditary Predisposition lifestyle factors Smoking Dietary Preferences

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