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Relation between hepatitis B virus genotypes and gene mutation of basic core promoter in li nationality

Journal of Nanjing Medical University 2009年第2期23卷 100-103页

作者： Juntao Zeng Zhengwen liu Shiping Zeng Jing Chen Department of lnfections Disease the First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061 China Department of Infections Disease the Affiliated Hospital of Hainan Medical College Haikou 570102 China

Objective：To investigate the relation between hepatitis B virus（HBV） genotypes and the double mutation of A-to-T nucleotide（nt） 1762 and G-to-A nt 1764 in basic core promoter（BCP T1762/A1764） in patients of the li nationality. Methods：Subjects were 125 HBV DNA positive patients that belong to the li nationality on Hainan Island. HBV DNA genotype was determined by real time fluorimetry polymerase chain reaction. BCP T1762/A1764 mutation was performed using the direct sequencing method. Results：The prevalence rates of genotype B, genotype C, genotype D, genotype C and D mixed infection（genotype C＋D） and genotype B and D mixed infection （genotype B ＋C） were 31.20%, 53.60%, 12.00%, 2.40% and 0.80% respectively. Mutation frequencies in patients infected with HBV genotype C（58.21%） were significantly higher than in those infected with other genotypes （P 〈 0.01 ）. The serum viral load of the patients with genotype C（5.74_＋ 1.21） was also higher than that of those with genotype B（P 〈0.01）. Conclusion：The major genotypes in the li nationality were genotype C and genotype B. The infection of genotype D and mixed infection also occurred in the li nationality. Genotype C HBV has a higher replication rate, and the different degrees of pathogenecity among HBV genotypes may be related to BCP T1762/ A1764 mutation frequency.

关键词： hepatitis B virus genotype gene mutation li nationality

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Study on the Relationship between 5-HttLPR Gene and BDNF Gene Polymorphism and Post-Traumatic Stress Disorder in li and Han nationality of Hainan Province

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Health 2022年第1期14卷 158-175页

作者： Haiyan lin Juncheng Guo Min Guo Xiangling Jiang The Fourth People’s Hospital of Haikou Haikou China Hainan Provincial People’s Hospital Haikou China

Objective: To investigate the correlation between 5-HTTLPR (5-and serotonin transporter linked polymer region) gene polymorphism and BDNF (brain derived neural factor) gene polymorphism and PTSD (post traumatic stress disorders) in li and Han nationalities in Hainan Province. Methods: 167 Hainan li PTSD patients, 141 Hainan Han PTSD patients and 158 healthy volunteers (control group) were investigated by ETI, caps, Toh, WCST, TMT and WAIS-RC. The polymorphisms of rs6265 locus of 5-HTTLPR and BDNF genes were detected by PCR (polymerase chain reaction) and page (polycylamide gel electrophoresis), and the correlation with PTSD was analyzed. Logistic regression analysis was used to analyze the influencing factors of PTSD. Results: The ETI score, total PTSD score and TMT time of li PTSD patients were significantly higher than those of Han PTSD patients (P ling, picture arrangement, operation IQ and total IQ of WAIS-RC were significantly lower than those of Han PTSD patients (P li PTSD patients and control group (P > 0.05). SS genotype of 5-HTTLPR and (GA + AA) genotype of rs6265 locus may increase the risk of PTSD in Hainan Han population. AA and GA + AA genotypes at rs6265 locus may increase the risk of PTSD in li population (P li PTSD patients, the ETI score, PTSD total score, TMT time, Toh planning time and execution time of AA genotype at rs6265 locus were significantly higher than those of GG genotype;the total scores of comprehension and operation IQ, and Toh in WAIS-RC were significantly lower than those in GG genotype (P < 0.05). Among Han PTSD patients, the ETI score, PTSD total score and TMT time of SS genotype of 5-HTTLPR were significantly high

关键词： 5-HTTLPR BDNF Gene Polymorphism Post-Traumatic Stress Disorder li nationality Han nationality Frequency Distribution

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