检索结果-南通市图书馆

Development and validation of a high throughput UPLC–MS/MS method for simultaneous quantification of esomeprazole,rabeprazole and levosulpiride in human plasma

引用

Journal of Pharmaceutical Analysis 2016年第3期6卷 190-198页

作者： Raja Haranadha Babu Chunduri Gowri Sankar Dannana School of Pharmaceutical Sciences and Technologies Jawaharlal Nehru Technological University Kakinada 533003 Andhra Pradesh India A.U. College of Pharmaceutical Sciences Andhra University Vishakapamam 530003 Andhra Pradesh. India

A high throughput ultra pressure liquid chromatography-mass spectrometry （UPLC-MS/MS） method with good sensitivity and selectivity has been developed and validated for simultaneous quantification of esomeprazole, rabeprazole and levosulpiride in human plasma using lansoprazole as internal standard （IS）. The extraction method based on liquid-liquid extraction technique was used to extract the analytes and IS from of 50 μL of human plasma using methyl tert-butyl ether：ethyl acetate （80：20, v/v）, which offers a high recovery. Chromatographic separation of analytes and IS was achieved on a Hypersil gold C18 column using gradient mobile phase consisting of 2 mM ammonium formate/acetonitrile. The flow rate was set at 0.5 mL/min to elute all the analytes and IS within 1.00 min runtime. Detection of target compounds was performed on a triple quadruple mass spectrometer by multiple reaction monitoring （MRM） mode via positive electrospray ionization （ESI）. Method validation results demonstrated that the developed method has good precision and accuracy over the concentration ranges of 0.1-2000 ng/mL for each analyte. Stability of compounds was established in a battery of stability studies, i.e., bench top, autosampler, dry extract and long-term storage stability as well as freeze-thaw cycles. The validated method has been successfully applied to analyze human plasma samples for application in pharmaco- kinetic studies.

关键词： Esomeprazole Rabeprazole levosulpiride UPLC-MS/MS Pharmacokinetic studies

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pharmacokinetics of levosulpiride after single and multiple intramuscular administrations in healthy Chinese volunteers

引用

Acta Pharmaceutica Sinica B 2014年第5期4卷 402-407页

作者： Chuting Gong Janvier Engelbert Agbokponto Wen Yang Ernest Simpemba Xiaohong Zheng Quanying Zhang Li Ding Department of Pharmaceutical Analysis China Pharmaceutical UniversityNanjing 210009China Organization for State Drug Clinical Trial the Second Affiliated Hospital of Soochow UniversitySuzhou 215004China

The main purpose of this study was to evaluate the pharmacokinetics of levosulpiride in humans after single and multiple intramuscular *** males and six females received single dose of either 25 mg or 50 mg levosulpiride,or multiple doses of 25 mg every 12 h for 5 consecutive *** the single 25 mg study,the mean peak plasma concentration(C max)was 441 ng/mL,the mean area under the concentration–time curve from 0 to 36 h(AUC_(0–36))was 1724 ng h/mL,and the mean elimination half-life(t_(1/2))was 7.0 *** the single 50 mg study,the mean C max was 823 ng/mL,the mean AUC_(0–36) was 3748 ng·h/mL,and the mean t_(1/2) was 6.8 *** multiple doses of 25 mg levosulpiride,the average plasma concentration(C av)was 136 ng/mL,the fluctuation index(DF)was 3.60,and the accumulation ratio(R)was *** injections appeared to be well tolerated by the subjects,and can be used for successive administration.

关键词： levosulpiride Pharmacokinetics Intramuscular administration Safety and tolerability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

levosulpiride和Domperidone治疗慢性功能性消化不良的临床效果及安全性

引用

世界临床药物 1993年第5期 315-315页

作者：贾伶

动力性消化不良是很常见的消化系统疾病,其发病机理尚不明确,病人胃排空减慢。临床上可用抗酸药、H;受体拮抗剂和胃动力剂等治疗。 Sulpiride具有对抗中心性和周围性多巴胺活性的作用,广泛地用于精神病的治疗。以往研究表明,此药的药理... 详细信息

动力性消化不良是很常见的消化系统疾病,其发病机理尚不明确,病人胃排空减慢。临床上可用抗酸药、H;受体拮抗剂和胃动力剂等治疗。 Sulpiride具有对抗中心性和周围性多巴胺活性的作用,广泛地用于精神病的治疗。以往研究表明,此药的药理活性主要与其左旋结构有关,左旋结构在50％以下的剂量比消旋结构有活性且副作用小。levosulpiride具有调节上消化道运动神经的作用。domper-idone对胃食道返流症及动力性消化不良有确切的疗效。作者采用随机双盲法对40例患有功能性消化不良的病人进行研究,levosulpiride每日剂量75mg,domperidone每日剂量60

关键词：病人功能性消化不良 levosulpiride Domperidone

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Electrogastrography associated with symptomatic changes after prokinetic drug treatment for functional dyspepsia

引用

World Journal of Gastroenterology 2012年第41期18卷 5948-5956页

作者： Hyun Chul Lim Sang In Lee Jiande DZ Chen Hyojin Park Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea Division of Gastroenterology Department of Internal MedicineUniversity of Texas Medical BranchGalvestonTX 77555United States

AIM:To evaluate the effect of prokinetic drugs on electrogastrography(EGG) parameters according to symptomatic changes in patients with functional dyspepsia(FD).METHODS:Seventy-four patients with FD were prospectively enrolled in this study between December 2006 and December *** surveyed the patients using a questionnaire on dyspeptic symptoms before and after an 8-wk course of prokinetic drug *** also measured cutaneous pre-prandial and postprandial EGG recordings including percentage of gastric waves(normogastria,bradygastria,tachygastria),dominant frequency(DF),dominant power(DP),dominant frequency instability coefficient(DFIC),dominant power instability coefficient(DPIC),and the ratio of post-prandial to fasting in DP before and after the 8-wk course of prokinetic drug ***:Fifty-two patients(70%) achieved symptomatic improvement after prokinetic drug *** who had normal gastric slow waves showed symptom improvement group after *** DF showed a downward trend in the symptom improvement group,especially in the itopride ***-prandial DP was increased regardless of symptom improvement,especially in the itopride group and mosapride ***-prandial DFIC and DPIC in the symptom improvement group were significantly increased after the *** EGG power ratio was increased after treatment in the symptom improvement group(0.50 ± 0.70 vs 0.93 ± 1.77,P = 0.002),especially in the itopride and levosulpiride ***:Prokinetics could improve the symptoms of FD by regulating gastric myoelectrical activity,and EGG could be a useful tool in evaluating the effects of various prokinetics.

关键词： Electrogastrography Functional dyspepsia Itopride Mosapride levosulpiride

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：