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Electrochemical study of the effect of functionalized nickel nanoparticles on cellular uptake of leukemia cancer cells in vitro

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Chinese Chemical Letters 2008年第5期19卷 577-580页

作者： Da Dong Guo Chun Hui Wu Xue Mei Wang Bao An Chen State Key Lab of Bioelectronics （Chien-Shiung Wu Lab） Southeast University Nanjing 210096 China Zhongda Hospital School of Clinical Medical Southeast University Nanjing 210096 China

In this study, we have fabricated the functionalized nickel nanoparticles and investigated their effects on cellular uptake of quercetin in leukemia K562 cancer cells by using electrochemical assay. The results indicate that nickel nanoparticles could efficiently enhance the quercetin uptake and increase the intracellular accumulation in cancer cells, implying the great potential of functionalized nickel nanoparticles in target cancer therapy.

关键词： Nickel nanoparticles leukemia cancer cells Quercetin Electrochemical assay

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The cellular labeling and pH-sensitive responsive-drug release of celastrol in cancer cells based on Cys-CdTe QDs

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Science China Chemistry 2014年第6期57卷 833-841页

作者： LI JingYuan SHI LiXin SHAO YiXiang SELKE Matthias CHEN BaoAn JIANG Hui WANG XueMei State Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory) Southeast University Laboratory Animal Center Institute of Comparative MedicineNantong University Department of Chemistry and Biochemistry California State University Department of Hematology Zhongda HospitalSoutheast University

As one of the active compounds derived from Traditional Chinese Medicine,Celastrol(CSL)had cytotoxicity for human leukemia cancer cells K562 and its multidrug-resistant cell line K562/***,we introduced cysteamine-modified CdTe QDs as the labeling and drug carrier into CSL research and found that the self-assembly and conjugation of anticancer molecular CSL with the Cys-CdTe QDs could significantly increase the drug’s cytotoxicity for K562 *** important,these CSL-Cys-CdTe nanocomposites could overcome the multidrug resistance of K562/A02 cells and efficiently inhibit the cancer cell proliferation by realizing the pH-sensitive responsive release of CSL to cancer *** enhanced cytotoxicity was caused by the increase of the G2/M phase arrest for K562/A02 cells as well as for K562 ***-CdTe QDs can readily bind on the cell plasma membranes and be internalized into cancer cells to trace and detect human leukemia cancer cells in real *** addition,these Cys-CdTe QDs can facilitate the inhibition of the multidrug resistance of K562/A02 cells and readily induce *** a good photosensitizer for the therapy,labeling,and tracing of cancer cells,the combination of CSL with Cys-CdTe QDs can optimize the use of and a new potential therapy method for CSL and yield new tools to explore the mechanisms of active compounds from Traditional Chinese Medicine.

关键词： celastrol cysteamine-modified CdTe QDs leukemia cancer cells labeling drug delivery

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