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Leucosceptroid B from glandular trichomes of leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis

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Chinese Journal of Natural Medicines 2019年第12期17卷 892-899页

作者： LING Yi TENG Lin-Lin HUA Juan LI De-Sen LUO Shi-Hong LIU Yan-Chun LIU Yan LI Sheng-Hong State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China

Obesity that is highly associated with numerous metabolic diseases has become a global health issue *** sesterterpenoids are an important group of natural products with great potential;thus,their bioactivities deserve extensive ***-seq analysis indicated that leucosceptroid B,a sesterterpenoid previously discovered from the glandular trichomes of leucosceptrum canum,significantly regulated the expression of 10 genes involved in lipid metabolism in Caenorhabditis ***,leucosceptroid B was found to reduce fat storage,and downregulate the expression of two stearoyl-CoA desaturase(SCD)genes fat-6 and fat-7,and a fatty acid elongase gene elo-2 in wild-type *** addition,leucosceptroid B significantly decreased fat accumulation in both fat-6 and fat-7 mutant worms but did not affect the fat storage of fat-6;fat-7 double *** findings indicated that leucosceptroid B reduced fat storage depending on the downregulated expression of fat-6,fat-7 and elo-2 and thereby inhibiting the biosynthesis of the corresponding unsaturated fatty *** findings provide new insights into the development and utilization of plant sesterterpenoids as potential antilipemic agents.

关键词： Sesterterpenoid Leucosceptroid B leucosceptrum canum Caenorhabditis elegans Fat accumulation Fatty acid biosynthesis Antilipemic agent

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Characterization of two chimeric sesterterpene synthases from a fungal symbiont isolated from a sesterterpenoid-producing Lamiaceae plant leucosceptrum canum

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Chinese Chemical Letters 2023年第1期34卷 279-283页

作者： Desen Li Minjie Yang Rongfang Mu Shihong Luo Yuegui Chen Wenyuan Li An Wang Kai Guo Yan Liu Shenghong Li State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China State Key Laboratory of Southwestern Chinese Medicine Resources and Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China College of Bioscience and Biotechnology Shenyang Agricultural UniversityShenyang 110866China University of Chinese Academy of Sciences Beijing 100049China

Two chimeric sesterterpene synthases(Aa TPS1 and Aa TPS2)were functionally characterized from Alternaria alternata MB-30 isolated from the leaves of a sesterterpenoid-producing Lamiaceae plant leucosceptrum *** TPS1 generated a 5/8/6/5 tetracyclic sesteraltererol(1)and its absolute stereochemistry was determined by X-ray crystallographic analysis of its derivative 10,11-epoxysesteraltererol(2),which enabled revision of the absolute configuration of C7 of sesterfisherol produced by Nf SS and PTTS014 characterized previously and its derivative 10,*** TPS2 produced a 5/15 bicyclic preterpestacin I(3).Site-directed mutagenesis suggested that F192 in Aa TPS1 was likely involved in controlling of the hydroxylation of C12,and eight amino acids were important for the enzyme activity of Aa TPS1 and Aa *** engineered Escherichia coli and Saccharomyces cerevisiae strains were constructed for the productions of compounds 1 and 3,and the highest titer of compound 1 reached 62.3 mg/L in shake-flask *** compounds 1 and 2 showed anti-adipogenic activity.

关键词： Sesterterpenoids Chimeric sesterterpene synthases Plant symbiotic fungi Alternaria alternata leucosceptrum canum Anti-adipogenic activity

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Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23

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Natural Products and Bioprospecting 2016年第3期6卷 155-160页

作者： Ce Kuang Shu-Xi Jing Yan Liu Shi-Hong Luo Sheng-Hong Li State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences(CAS)Kunming 650201People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

Three new drimane sesquiterpenoids(1–3)together with the known 2a-hydroxyisodrimeninol(4),and a new isochromone derivative(5),were obtained from the solid cultures of fungal strain Pestalotiopsis sp.M-23,an endophytic fungus isolated from the leaves of leucosceptrum canum(Labiatae).Their structures were determined by comprehensive 1D and 2D NMR,and MS *** metabolites were evaluated for their antibacterial activities,and compound 3 showed weak inhibitory activity against Bacillus subtilis.

关键词： Endophytic fungi Pestalotiopsis sp.M-23 leucosceptrum canum Drimane sesquiterpenoids Antibacterial activity

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