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Lack of evolutionary changes identified in SARS-CoV-2 for the re-emerging outbreak of COVID-19 in Beijing,China

Biosafety and Health 2022年第1期4卷 1-5页

作者： Yang Li Yunjun Zhang Mifang Liang Yi Zhang Xuejun Maa Yong Zhang Xiaohua Zhou NHC Key Laboratory of Medical Virology and Viral Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Chongqing School University of Chinese Academy of Sciences(UCAS)Chongqing 400020China Department of Biostatistics School of Public HealthPeking UniversityBeijing 100876China Beijing International Center for Mathematical Research Peking UniversityBeijing 100876China Center for Statistical Science Peking UniversityBeijing 100876China

Although significant achievements have shown that the coronavirus disease 2019(COVID‐19)resurgence in Beijing,China,was initiated by contaminated frozen products and transported via cold chain transportation,international travelers with asymptomatic symptoms or false‐negative nucleic acid may have another possible transmission mode that spread the virus to *** of the key differences between these two assumptions was whether the virus actively replicated since,so far,no reports showed viruses could stop evolution in alive *** studied severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2)sequences in this outbreak by a modified leaf‐dating method with the Bayes *** numbers of single nucleotide variants(SNVs)found in SARS‐CoV‐2 sequences were significantly lower than those called from B.1.1 records collected at the matching time worldwide(P=0.047).In addition,results of the leaf‐dating method showed ages of viruses sampled from this outbreak were earlier than their recorded dates of collection(Bayes factors>10),while control sequences(selected randomly with ten replicates)showed no differences in their collection dates(Bayes factors<10).Our results which indicated that the re‐emergence of SARS‐CoV‐2 in Beijing in June 2020 was caused by a virus that exhibited a lack of evolutionary changes compared to viruses collected at the corresponding time,provided evolutionary evidence to the contaminated imported frozen food should be responsible for the reappearance of COVID‐19 cases in *** method developed here might also be helpful to provide the very first clues for potential sources of COVID‐19 cases in the future.

关键词： Molecular clock Frozen virus leaf‐dating Bayes factors SARS‐CoV‐2

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