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In Vitro Activity of lawsonia inermis （Henna） on Some Pathogenic Fungi

Journal of Agricultural Science and Technology(A) 2014年第8期4卷 657-662页

作者： Elham Abdelbasit Suleiman Elbasheir Ahmmed Mohamed Mycology Department Veterinary Research Institute Animal Resources Research Corporation Khartoum 12217 Sudan Microbiology Department Faculty of Medical Laboratories Science Omdurman Islamic University Khartoum 12217 Sudan

The present study was conducted to investigate antifungal activity oflawsonia inermis （Henna plant）. Leaf samples of the plants were collected from Eastern Nile of Khartoum state, Sudan. Ethanol and petroleum ether extracts in various concentrations were obtained by maceration （cold method）. The extracts were bioassay in vitro to know their bioactivity to inhibit the growth of tested fungi. The cup plate agar diffusion method was adopted to assess the antifungal activity of the extracts against tested yeasts while agar incorporated method was used for other molds. Both extracts revealed anti fungal activity against all yeast strains except Pichiafabianii which was found resistant to both ethanol and ether extracts. The results displayed antifungal activity against tested fungi. Minimum mould concentration （MMC） of the extracts was determined. The obtained results revealed antifungal activity of henna leaves extracts which support the traditional use of the Henna in therapy of fungal infections. The possibility of therapeutic use of Sudanese henna as antifungal agents is recommended.

关键词： lawsonia inermis antifungal ether ethanol extracts inhibition zone.

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Antiplasmodial mechanism of lawsonia inermis: An in silico based investigation

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Infectious Diseases Research 2024年第1期5卷 8-26页

作者： Ridwan Abiodun Salaam Funmilayo I.D.Afolayan Department of Zoology University of IbadanIbadan 200005Nigeria.

Background:lawsonia inermis has been widely reported to be used as an herbal treatment for ***,despite several experimental studies about its antimalarial activities,the approach through which the herbal plant suppresses plasmodium infection is yet to be ***,this study uses computational approaches to understand the biological targets and pathways involved in the antiplasmodial activities of lawsonia inermis ***:The Gas Chromatography-Mass Spectrometry technique identified the phytocompounds present in the herbal ***,OMIM,and NCBI databases were explored to collate target proteins for further network pharmacology *** phytocompounds were subjected to Absorption,Distribution,Metabolism,Excretion and Toxicity(ADMET)and druglikeness *** STRING algorithm and Cytoscape were employed to develop and analyze the relationships among target proteins and compounds/targets/pathways network of the putative targets of the *** computational analysis was carried out to identify potential drug ***:Based on the Network Pharmacology studies,phytocompounds in lawsonia inermis exhibit antiplasmodial activity by interacting with therapeutic genes that play essential roles in metabolism and signaling *** among the genes are MMP9,MAPK1,HMOX1 and ***,the most influenced pathways include the metabolic pathway,PI3K-Akt signaling pathway,and HIF-1 signaling *** analysis,molecular docking analysis,and molecular dynamics simulation revealed that 3-phenyl-2-Isoxazoline and 2-Dimethylamino-3’-methoxyacetophenone are recommendable drug leads for Malaria treatment as they form stable and favorable complexes with Matrix metalloproteinase-9(MMP9)***:The 3-phenyl-2-Isoxazoline and 2-Dimethylamino-3’-methoxyacetophenone phytocompounds from lawsonia inermis herbal plant are predicted as antimalarial drug candidates and recommended for further wet-lab studies.

关键词： lawsonia inermis computational studies plasmodium falciparum network pharmacology molecular dynamic

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Phytochemical Analysis and Antimicrobial Activity of lawsonia inermis Leaf Extracts from Burkina Faso

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American Journal of Plant Sciences 2024年第7期15卷 552-576页

作者： Ollo Youl Soumaïla Konaté Ernest N. Sombié Rainatou Boly Boukaré Kaboré Moumouni Koala Arouna Zoungrana Saybou Savadogo Christian Marc Tahita Innocent Valea Halidou Tinto Adama Hilou Maminata Traoré-Coulibaly Laboratoire de Biochimie et de Chimie Applique (LABIOCA) Universit de Ouagadougou Ouagadougou Burkina Faso Agence Nationale Pour la Scurit Sanitaire de lEnvironnement de lAlimentation du Travail et des Produits de Sant (ANSSEAT) Ouagadougou Burkina Faso Laboratoire de Recherche-Dveloppement de Phytomdicaments et Mdicaments (L-RD/PM) Institut de Recherche en Sciences de la Sant (IRSS-CNRST) Ouagadougou Burkina Faso Laboratoire de Chimie Organique et de Physique Applique (LCOPA) cole Doctorale Sciences et Technologie Universit Joseph KI-ZERBO Ouagadougou Burkina Faso Laboratoire Sciences de la Vie et de la Terre (LASVT) cole Doctorale Sciences et Technologie Universit Norbert ZONGO Koudougou Burkina Faso Unit de Recherche Clinique de Nanoro Institut de Recherche en Sciences de la Sant (IRSS-CNRST) Nanoro Burkina Faso

lawsonia inermis is a hairless plant growing in various regions of North Africa, the Indian subcontinent, and the Middle East. It possesses many medicinal attributes, including curative properties against infectious dermatoses. This study was carried out to evaluate the phytochemical profile of the crude ethanolic extract of the plant leaves and its fractions as well as their antimicrobial activities. The phytochemical profile was performed using high-performance thin-layer chromatography (HPTLC), gas chromatography-mass spectrometry (GC-MS), and high-performance liquid chromatography (HPLC). Additionally, the phenolic and flavonoid contents were determined using the Folin-Ciocalteu spectrophotometric and the aluminum trichloride methods. Antimicrobial activity was tested using disc diffusion and microdilution methods. The presence of flavonoids, tannins, sterols, and triterpenes was revealed. GC-MS detected twelve compounds main compounds consisting of saturated and unsaturated fatty acids and phenolic and terpenoid compounds among twenty-seven components. HPLC also detected high contents of phenolic acids and flavonoids. The most abundant triterpene and sterols were ursolic acid (around 43.14 g/100g DW, 13.9 g/100g dry weight (DW), and 0.68 g/100g DW) in the crude ethanolic extract of leaves (FeLi), hexane fraction (FHLi) and dichloromethane fraction (FDLi), respectively and, β-sitosterol in FeLi (56.7 mg/100g DW), FHLi (10.55 g/100g DW), FDLi (106.1 mg/100g DW) and butanol fraction (FBLi) (357.4 mg/100g DW). Among the flavonoids, rutin = 3.24 g/100g and quercetin = 0.63 g/100g in the ethanolic extract, rutin = 15.73 g/100g in the dichloromethane fraction, and rutin = 0.23 g/100g) in the aqueous fraction;and among phenolic compounds, caffeic acid (37.65 g/100g DW) and vanillic acid (22.70 g/100g DW) were the most important in the ethyl acetate fraction (FAeLi). All organic fractions exhibited interesting antibacterial and antifungal activities against the tested s

关键词： lawsonia inermis Phytochemical Profile HPLC GC-MS Analysis Antimicrobial Activity

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