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Investigation of DNA Sequences Related to latency-associated Transcripts in the Genome of Canine Herpesvirus Type 1 (CHV-1) by Means of Bioinformatics Tools

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Open Journal of Veterinary Medicine 2019年第10期9卷 147-160页

作者： Ortiz M. A. Herná ndez Verde C. Cuenca Lara E. G. Valdivia Anda G. Valdivia Laboratory of Microbial Pathogenicity Multidisciplinary Research Unit Faculty of Higher Education Cuautitlan National Autonomous University of Mexico Cuautitlan Izcalli Mexico

A characteristic common to herpesviruses is the ability to establish a latent infection in the hosts, a transcriptionally active region has detected during latency as well as a set of RNA that are known as latency associated Transcripts (LATs), their functions have been clarified in recent work. The present work was carried using different bioinformatics method in order to determine if Herpesvirus Canine 1 (CHV-1) has a region associated with latency. Our result was the selection of nine sequences candidate of micro RNA (miRNA) (MIREval 2.0 software), and 26 miRNA (miRNAFold v.1.0 software), of them, were selected 14 with real precursors of miRNA, two were found between the RL2 and RS1 genes, one in the RL2 gene and 11 in the RS1 gene. The results showed that the similarities of these regions are very low among the herpesviruses analyzed, so it was not possible to deduce the presence of the LAT gene in canine herpesvirus type 1 with bioinformatics. On the other hand, the comparison showed that the miRNA predicted: chv1-mir-mirnafold-8 has similarity with the ebv-mir-BART7-3p of Epstein-Barr Virus (EBV), in this way, the microRNAs predicted by means of bioinformatic programs met the theoretical requirements of these molecules, however at not having a degree of preservation in other herpesviruses, the expression by CHV-1 in latency cannot be confirmed and it is necessary to identify through experimental tests.

关键词： latency Canine Herpesvirus latency-associated Transcripts

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The Role, Mechanism and Transcriptional Regulation of LAT in Herpes Simplex Virus latency and Reactivation

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Yangtze Medicine 2020年第1期4卷 39-53页

作者： Ying Zhang Yingying Wang Junting Cheng Wenqi Cai Ziwen Han Yang Zhou Qi Huang Moyu Wang Xiaochun Peng Xianwang Wang Zhaowu Ma Ying Xiang Hongwu Xin Laboratory of Oncology Center for Molecular Medicine School of Basic Medicine Health Science Center Yangtze University Jingzhou China Department of Biochemistry and Molecular Biology School of Basic Medicine Health Science Center Yangtze University Jingzhou China Department of Pathophysiology School of Basic Medicine Health Science Center Yangtze University Jingzhou China Department of Laboratory Medicine School of Basic Medicine Health Science Center Yangtze University Jingzhou China

Herpes simplex virus (HSV) infection in the human body can be latent in neurons for long time and be reactivated leading to recurrence at high rate. Currently there is no effective clinical strategy for the prevention and treatment of the disease relapse. HSV LAT gene is expressed in large quantities and lytic genes are turned off leading to HSV latency. Disruption of the gene expression is thought to cause HSV reactivation and disease relapse. To reveal the essence of HSV latency and reactivation, we summarized and innovatively classified the role, mechanism and transcriptional regulation of LAT in HSV latency and reactivation. This review may have important implications for future studies on HSV latency and reactivation, HSV disease prevention and treatment, and safer and more effective oncolytic HSVs (oHSVs).

关键词： Herpes Simplex Virus (HSV) Oncolytic Herpes Simplex Virus (oHSV) latency-associated Transcript (LAT) Reactivation Immediate-Early Gene (IE Gene)

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