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Fuel source shift or cost reduction:Context-dependent adaptation strategies in closely related Neodon fuscus and lasiopodomys brandtii against hypoxia

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Zoological Research 2022年第4期43卷 497-513页

作者： Xiu-Juan Li Cong-Cong Qiao Bo-Jian Chen Meng-Yang Li Peng Chen Mao-Lin Huang Chun-Xiao Chen Yan Liu Han Cheng Meng-Wan Jiang Lu-Ye Shi Zhen-Long Wang School of Life Sciences Zhengzhou UniversityZhengzhouHenan 450001China College of Environmental Science and Engineering Tongji UniversityShanghai 200092China Jiaxing-Tongji Environmental Research Institute JiaxingZhejiang 314051China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650223China School of Artificial Intelligence and Big Data Henan University of TechnologyZhengzhouHenan 450001China

Oxygen is essential for most life *** oxygen supply can disrupt homeostasis and compromise survival,and hypoxia-induced cardiovascular failure is fatal in many animals,including ***,certain species have adapted and evolved to cope with hypoxic environments and are therefore good models for studying the regulatory mechanisms underlying responses to ***,we explored the physiological and molecular responses of the cardiovascular system in two closely related hypoxiaadapted species with different life histories,namely,Qinghai voles(Neodon fuscus)and Brandt’s voles(lasiopodomys brandtii),under hypoxic(10%O_(2) for 48 h)and normoxic(20.9%O_(2) for 48 h)*** mice(Mus musculus)were used for *** voles live in plateau areas under hypoxic conditions,whereas Brandt’s voles only experience periodic *** and hematological analyses indicated a strong tolerance to hypoxia in both species,but significant cardiac tissue damage and increased blood circulation resistance in mice exposed to *** transcriptome analysis revealed enhanced oxygen transport efficiency as a coping mechanism against hypoxia in both *** and ***,but with some ***,*** showed upregulated expression of genes related to accelerated cardiac contraction and angiogenesis,whereas *** showed significant up-regulation of erythropoiesis-related *** upregulation of hemoglobin synthesis-related genes was observed in both *** addition,differences in cardiometabolic strategies against hypoxia were observed in the ***,*** relied on adenosine triphosphate(ATP)generation via fatty acid oxidation,whereas *** shifted energy production to glucose oxidation under hypoxic conditions and *** employed a conservative strategy involving down-regulation of fatty acid and glucose oxidation and a bradycardia *** conclusion,the cardiovascular sys

关键词： Heart Hypoxia lasiopodomys brandtii Neodon fuscus RNA sequencing

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Brandt's vole(lasiopodomys brandtii) show remarkably stronger hypoxia tolerance than mouse

Brandt's vole(Lasiopodomys brandtii) show remarkably stronge...

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2019中国生理学会学术年会暨张锡钧基金第十五届全国青...

作者：李蔚 Dong Yanan Dong Qianqian Sun Hong Zhang Yifeng Wang Zhenlong School of Basic Medical Sciences Zhengzhou University School of life sciences Zhengzhou university

Oxygen(O) is essential for the survival of most animal species;however, O levels are lower than normal in certain spaciotemporal ***, animals have to develop some strategies to face and adapt to this *** study compared the differences in survival,behavior, and hippocampal neurons under hypoxic conditions between Brandt’s voles(lasiopodomys brandtii) and mice(Mus musculus).Their survival times were significantly affected by hypoxia exposure;the survival test demonstrated that Brandt’s voles tolerated a minimum O level of 5.5% for 6 h *** 7.5% observed for ***’s voles exhibited a significantly better recognition under hypoxic conditions than that exhibited by mice, and the two species showed better results under normoxia than under *** novel object recognition test(NORT) and neuronal nuclei staining revealed the presence of species-dependent learning deficits under hypoxic *** showed that the mice exposed to 7.5% O2 levels had significant learning deficits compared with mice, and their discrimination index(DI) was lower than that observed in the normoxia ***, Brandt’s voles exposed to 7.5% O2 levels had no significant learning deficits compared with the normoxia group, and their DI was higher than that observed in the normoxia *** loss in the CA1 and CA3 regions of the hippocampus was also species *** loss in the hippocampus of mice exposed to 7.5% O2 levels was significantly greater than that observed in the normoxia *** Brandt’s voles, neuronal loss in the hippocampus was significantly greater under exposure to 5.5% O2 levels than that under normoxia or exposure to 7.5% O2 *** can have significant effects on survival, cognitive behavior,and neuronal ***, Brandt’s voles showed stronger hypoxia tolerance than did mice and could be harnessed as a natural hypoxia-tolerant animal model to study adaptation to hypoxia exposure.

关键词： lasiopodomys brandtii hypoxia tolerance survival analysis NORT NeuN staining

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Effects of host identity on the gut microbiota:A comparative study on three microtinae species

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Animal Models and Experimental Medicine 2024年第2期7卷 98-105页

作者： Zhen Yao Wenli Zhao Baohong Tang Qinghua Li Zhenlong Wang School of Life Sciences Zhengzhou UniversityZhengzhouHenan ProvinceP.R.China

Background:Gut microbiota exert an immense effect on host health and host environmental ***,the composition and structure of gut microbiota are determined by the environment and host genetic ***,the relative contribution of the environment and host genetic factors toward shaping the structure of gut microbiota has been poorly ***:In this study,we characterized the fecal microbial communities of the closely related voles Neodon fuscus,lasiopodomys brandtii,and *** after caged feeding in the laboratory for 6 months,through high-throughput sequencing and bioinformatics ***:The results of pairwise comparisons of *** *** and *** *** revealed significant differences in bacterial diversity and composition after *** 991 same operational taxonomic units(OTUs)were shared in three voles,there were 362,291,and 303 species-specific OTUs in ***,***,and ***,*** relative abundances of Proteobacteria and Prevotella,which are reported to be enriched in high-altitude populations,were significantly higher in high-altitude *** than in low-altitude *** after ***,which produce various digestive enzymes for energy metabolism,and Spirochaetes,which can degrade cellulose,were found in higher abundance in subterranean *** than that in *** which dwells on the earth ***:Our findings showed that some components of gut microbiota still maintained dominance even when different host species are reared under the same environmental conditions,suggesting that these bacteria are substantially influenced by host factors.

关键词： gut microbiota high-altitude lasiopodomys brandtii Neodon fuscus

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