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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Shan-Bao TONG~*,Peng MIAO,Min-Heng LI,Hong-Yang LU,Qi LIU,Yao LI School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 2000240,China

＜正＞Objective laser speckle contrast analysis has been used in imaging the cerebral vasculature and cerebral blood flow（CBF）.However,in practice,the estimation of the CBF may be biased by the ambient background field, dark current and other anomalies in the circuits of CCD camera,non-uniform distributed laser illumination,cortical curvature,breathing/heart beating of the subjects,and the nonstationary change of CBF under functional stimulation, and the motion artifacts if applied to the behavioring *** In order to obtain a stable and high spatiotemporal resolution CBF imaging in the study of the ischemic brain injury,we developed several techniques to improve the current techniques of laser speckle contrast analysis,including（1） enhanced laser speckle contrast analysis （eLASCA）;（2） model Based LSI reconstruction;（3） registered laser speckle contrast analysis（rLASCA）;（4） Random process estimator for laser speckle *** finally we integrate these techniques and designed a miniature headstage imaging system which can be used to obtain the CBF imaging when the animal（***） is moving freely. Results By using the above techniques,high resolution CBF information can be obtained in real time for either anesthetized or freely moving *** We developed high-resolution optical imaging technique for CBF monitoring,which can be used for real time monitoring both structural and functional neurovascular changing in ischemic brain injury.

关键词： neurovascular imaging cerebral blood flow laser speckle imaging laser speckle contrast analysis

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Waggle needling Yanglingquan(GB34) enhances cerebral blood flow and ameliorates condition of spastic paresis in rats with middle cerebral artery occlusion induced by surgical nylon suture

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Journal of Traditional Chinese Medicine 2023年第3期43卷 514-522页

作者： ZHANG Zhou MU Jiedan MA Liangxiao YU Wenyan SUN Tianyi QIAN Xu TIAN Yuan ZHANG Yidan WANG Junxiang School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China the Key Unit of State Administration of Traditional Chines Medicine Evaluation of Characteristic Acupuncture TherapyBeijing 100029China School of Nursing Beijing University of Chinese MedicineBeijing 100029China

OBJECTIVE:To evaluate the therapeutic efficacy and the influence on cerebral blood supply of waggle needling Yanglingquan(GB34) on spastic paresis(SP) rats after middle cerebral artery occlusion(MCAO) induced and investigate its mechanism of relieving neurobehavior ***:SP rat model was produced by permanent *** were divided into five groups:blank control group(Control),sham operation group(Sham),model group(Model),waggle needling group(WN) and perpendicular needling group(PN).SP rats were treated with acupuncture from day 3 after MCAO,once a day for 6 *** modified neurological severity score(m NSS) and modified Ashworth scale(MAS) were conducted on days 0,1,3,5,7 and *** blood flow(CBF) in ischemic cortex was measured by laser speckle imaging 5 min pre ischemia,5 min post ischemia,and after intervention on day *** rats were sacrificed at day 9 and the protein and m RNA expressions of γ2 subunit of the γ-aminobutyric acid receptor A(GABAAγ2) and K+-Cl-cotransporter 2(KCC2) in the ischemic cortex and lumber enlargement was measured by Western blotting and real-time quantitative polymerase chain ***:Both Control and Sham groups showed no changes in m NSS and MAS scores and in the regional *** with Model group,both WN and PN treatments significantly ameliorated neurological deficit(P < 0.01),decreased muscle tone(P < 0.05),and enhanced CBF(P < 0.001) in SP rats;moreover,WN showed superior effects than PN(P < 0.001).In line with the improvement in neurobehavior,acupuncture interventions up-regulated the expressions of GABAAγ2 and KCC2 in the ischemic cortex as well as lumber enlargement(P < 0.01) in SP rats,and those changes were more obvious in WN(P < 0.05).CONCLUSIONS:Acupuncture at Yanglingquan(GB34) enhanced cerebral blood flow and ameliorated SP in permanent MCAO rats,while waggle needling was superior to regular perpendicular *** needling Yanglingquan(GB34) would be a potential complementary therapy

关键词： spastic paresis acupuncture cerebrovascular circulation laser speckle imaging γ2 subunit of theγ-aminobutyric acid receptor A K+-Cl-cotransporter 2

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Separation of cortical arteries and veins in optical neurovascular imaging

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Journal of Innovative Optical Health Sciences 2014年第3期7卷 22-30页

作者： Linna Zhao Yao Li Hongyang Lu Lu Yuan Shanbao Tong Med-X Research Institute Shanghai Jiao Tong University1954 Huashan Rd.Shanghai 200030P.R.China School of Biomedical Engineering Shanghai Jiao Tong University800 Dongchuan Rd. Shanghai 200240P.R.China School of Life Science and TechnologyHuazhong University of Science and Technology 1037 Luoyu Rd. Wuhan 430074P.R.China

Separation of arteries and veins in the cerebral cortex is of significant importance in the studies of cortical hemodynamics,such as the changes of cerebral blood flow,perfusion or oxygen con-centration in arteries and veins under different pathological and physiological *** the cerebral vessel segmentation and vessel-type separation are challenging due to the complexity of cortical vessel characteristics and low spatial signal-to-noise *** this work,we presented an effective full-field method to differentiate arteries and veins in cerebral cortex using dual-modal optical imaging technology including laser speckle imaging(LSI)and optical intrinsic signals(OIS)*** raw contrast images were acquired by LSI and processed with enhanced laser speckle contrast analysis(eLASCA),*** vascular pattern was extracted and seg-mented using region growing algorithm from the eLASCA-based ***,OIS imageswere acquired altermatively with 630 and 870 nm to obtain an oxy hemoglobin concentration mapover cerebral *** the separation of arteries and veins was accomplished by Otsuthreshold segmentation algorithm based on the OIS information and segmentation of ***,the segmentation and separation performances were assessed using area overlap measure(AOM).The segmentation and separation of cerebral vessels in cortical optical imaging have great potential applications in full-field cerebral hemodynamics monitoring and pathological study of cerebral vascular diseases,as well as in clinical intraoperative monitoring.

关键词： Vessel segmentation laser speckle imaging optical intrinsic signals imaging regiongrowing algorithm artery-vein separation.

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Monitoring of rhythms in laset speckle data

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Journal of Innovative Optical Health Sciences 2014年第3期7卷 73-82页

作者： D.E.Postnov A.Y.Neganova D.D.Postnov A.R.Brazhe Physics Department Saratov State University Astrakhanskaya St.83Saratov 410012Russia Biophysics Department Biological FacutyMoscow State UniversityLeninskie Gory 1Building 12119991 MoscowRussia

While the laser speckle imaging(LSI)is a powerful tool for multiple biomedical applications,suchas monitoring of the blood flow,in many cases it can provide additional information when combined with spatio-temporal rhythm *** demonstrate the application of GraphicsProcessing Units(GPU)-based rhythm analysis for the post procesing of LSI data,discuss therelevant structure of GPU-based computations,test the proposed technique on surrogate 3D data,and apply this approach to kidney blood fiow *** with surrogate data demonstrate the ability of the method to extract information about oscillation patterns fromnoisy data,as well as to detect the moving source of the *** analysis of kidney dataallow us to detect and to localize the dymamics arising from autoregulation processes at the levelof individual nephrons(tubuloglomerular feedback(TGF)rhythm),as well as to distinguishbetween the TGF-active and the TGF-silent zones.

关键词： laser speckle imaging wavelet transform kidney autoregulation.

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Sample entropy analysis of laser speckle fluctuations to suppress motion artifact on blood flow monitoring

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Chinese Optics Letters 2022年第1期20卷 106-111页

作者： Sungchul Kim Evgenii Kim Eloise Anguluan Jae Gwan Kim Department of Biomedical Science&Engineering Institute of Integrated TechnologyGwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea Center for Bionics Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

laser speckle imaging is a common technique to monitor blood *** fluctuations in speckle intensity can be related to the blood flow by calculating the speckle contrast,the ratio between the standard deviation of speckle fluctuations and the average ***,this simple statistic calculation is easily affected by motion *** this study,we applied sample entropy analysis instead of calculating standard deviations of the speckle *** to the traditional method,sample entropy-based speckle contrast increases linearly with flow rate but was shown to be more immune to sudden movements during an upper arm occlusion test.

关键词： laser speckle imaging sample entropy speckle contrast blood flow monitoring motion artifact

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Optical dynamic imaging of the regional blood flow in the rat mesentery under the effect of noradrenalin

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Progress in Natural Science:Materials International 2003年第5期 79-82页

作者： CHENG Haiying, LUO Qingming, ZENG Shaoqun, CEN Jian and LIANG Wenxi(The Key Laboratory of Biomedical Photonics of Ministry of Education of China, Huazhong University of Science and Technology, Wuhan 430074, China) The Key Laboratory of Biomedical Photonics of Ministry of Education of China Huazhong University of Science and Technology Wuhan 430074 China

The regional blood flow in the rat mesentery under the effect of noradrenalin is monitored using the laser speckle imaging method. The results show that at the third minute of application of noradrenalin, the blood flow begins to decrease, and the venule blood flow decreases more rapidly than that in the arteriole. Five minutes later blood flow in part of blood vessels begins to resume and the blood flow in the arteriole recovers more quickly than that in the venule. These suggest that laser speckle imaging can obtain the temporal-spatial characteristic of blood flow in mesentery without the need of scanning. It provides a new approach for investigating the change of regional blood flow in the mesentery in microcirculation studies.

关键词： laser speckle imaging mesentery regional blood flow.

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