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laser in situ keratomileusis in adult patients with anisometropic amblyopia

International Journal of Ophthalmology(English edition) 2013年第3期6卷 362-369页

作者： Alper Agca Engin Bilge zgühan kkes Baz Ercüment Bozkurt Abdullah Ozkaya Dilek Yasa Ahmet Demirok Beyoglu Eye Research and Training Hospital Department of Ophthalmology Istanbul Medeniyet University

AIM: To evaluate the increase in corrected distance visual acuity (CDVA) after laser in situ keratomileusis (LASIK) in adults with anisometropic amblyopia. · METHODS: The medical records of consecutive patients diagnosed with anisometropic amblyopia at the time of refractive evaluation who underwent LASIK were retrospectively reviewed. Patients with at least a two-line difference of visual acuity (VA) between the eyes with a spherical refractive error difference of at least 3.00 diopters (D) or an astigmatic difference of at least 2.00D were included. Patients with any other possible reason for amblyopia other than anisometropia or those who had undergone previous amblyopia treatment were excluded. Amblyopic eyes with myopia or myopic astigmatism were considered as group 1, hypermetropia or hypermetropic astigmatism constituted group 2, and mixed astigmatism patients comprised group 3. Uncorrected distance visual acuity (UDVA), subjective manifest refraction, and CDVA were analyzed at 1 week and 1 month, 3, and 6 months. ·RESULTS: The study included 57 eyes of 57 patients. There were 33 eyes in group 1, 12 eyes in group 2, and 12 eyes in group 3. The preoperative mean values for spherical equivalent of subjective manifest refraction (SE) in groups 1, 2, and 3 were (-4.66±1.97)D, (4.40±1.00)D, and (0.15±1.05)D, respectively. Mean CDVA improved 0.1 log units (1 line LogMAR) at 6 months (P 0.05). Moreover, age, the amount ofpreoperative refractive error, and the levels of preoperative corrected and UDVA had no effect on postoperative CDVA improvement (P >0.05). · CONCLUSION: Correction of refractive errors with LASIK produced significant CDVA improvement in adult patients with anisometropic amblyopia and no previous ambl

关键词： amblyopia laser in situ keratomileusis refractive surgery visual acuity

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Using laserSight Astrapro Planner 2.2 Z software in corneal topography-guided laser in situ keratomileusis for myopia with asymmetric corneal shape

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 452-456页

作者： Bing Liu Wei Chen De-Wang Shao Hua Wang Hai-Xia Ru Min Zhang Ying Wang Chun-Yan Yang Department of Ophthalmology Air Force General Hospital of PLA

AIM:To determine the clinical outcomes of laser insitu keratomileusis(LASIK)treatments using laserSight AstraPro Planner 2.2 Z software for myopia with asymmetric corneal ***:Four hundred and eighty-five eyes[243patients;spherical equivalent(SE),-5.93±1.88 diopters(D)]were treated with asymmetric ablations using laserSight SLX laser(version 5.3,300Hz)were retrospectively analyzed and laserSight AstraPro Planner2.2 Z *** and postoperative uncorrected visual acuities(UCVA),spherical equivalent(SE)refraction,pachymetry,and corneal asphericity(Q value)and decentration were ***:At 12mo postoperatively,the decimal UCVA was 1.0 or better in 449(92.6%)*** eyes(0.4%)lost 1 line of the decimal best spectacle-corrected visual acuity(BCVA),316(65.2%)did not change,149(30.7%)gained 1 line,and 18(3.7%)gained 2 lines or more after *** hundred and thirty-two eyes(68.5%)were within 0.5 D in *** mean tissue saving ablation depth was 4.28±2.86(0-16)μm(median,4μm).The mean attempted remaining central corneal thickness was435.79±29.56μm,the mean postoperative pachymetry was 444.94±28.93μ*** mean preoperative Q value was-0.19±0.18,the postoperative was 0.30±0.48(P=0.000).The mean postoperative decentration was 0.39±0.19 ***:Topography-guidedLASIKwithAstraPro Planner 2.2 Z custom ablation planning software in an asymmetric ablation mode was an effective,safe,predictable,and stable refractive procedure for the myopia with asymmetric corneal topography.

关键词： myopia laser in situ keratomileusis corneal topography asymmetric ablation

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Comparison of visual acuity of the patients on the first day after sub-Bowman keratomileusis or laser in situ keratomileusis

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 448-452页

作者： Wei Zhao Ting Wu Ze-Hong Dong Jie Feng Yu-Feng Ren Yu-Sheng Wang Department of Ophthalmology Xijing Hospitalthe Fourth Military Medical University Out-patient Department the Second Artillery Engineering University

AIM：To compare recovery of the visual acuity in patients one day after sub-Bowman keratomileusis（SBK）or laser in situ keratomileusis（LASIK）.· METHODS：Data from 5923 eyes in 2968 patients that received LASIK（2755 eyes） or SBK（3168 eyes） were retrospectively *** eyes were divided into 4groups according to preoperative spherical equivalent：between-12.00 to-9.00 D,extremely high myopia（n =396,including 192 and 204 in SBK and LASIK groups,respectively）;-9.00 to-6.00 D,high myopia（n=1822,including 991 and 831 in SBK and LASIK groups,respectively）,-6.00 to-3.00 D,moderate myopia（n=3071,including 1658 and 1413 in SBK and LASIK groups,respectively）,and-3.00 to 0.00 D,low myopia（n =634,including 327 and 307 in SBK and LASIK groups,respectively）.Uncorrected logMAR visual acuity values of patients were assessed under standard natural *** of variance was used for comparisons among different groups.· RESULTS：Uncorrected visual acuity values were0.0115±0.1051 and 0.0466±0.1477 at day 1 after operation for patients receiving SBK and LASIK,respectively（P〈0.01）;visual acuity values of 0.1854±0.1842,0.0615±0.1326,-0.0033±0.0978,and-0.0164±0.0972 were obtained for patients in the extremely high,high,moderate,and low myopia groups,respectively（P〈0.01）.In addition,significant differences in visual acuity at day 1 after operation were found between patients receiving SBK and LASIK in each myopia subgroup.· CONCLUSION：Compared with LASIK,SBK is safer and more effective,with faster ***,SBK is more likely to be accepted by patients than LASIK for better uncorrected visual acuity the day following operation.

关键词： sub-Bowman keratomileusis laser in situ keratomileusis visual acuity myopia recovery

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Influence of transient intraocular pressure elevation during laser in situ keratomileusis on rabbit retina thickness

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1089-1093页

作者： Hai-Xia Zhao Hui Liu Chun-Mei Niu Wen-Ying Guan Department of Ophthalmology the Affiliated Hospital of Inner Mongolia Medical University

AIMTo utilize tissue micro measurement to study the effect of transient high intraocular pressure (IOP) induced by different durations of suction during laser in situ keratomileusis (LASIK) on rabbit retina *** healthy New Zealand white rabbits were randomly divided into a control group, and 3 negative-pressure suction groups (20s group, 45s group, and 3min group) and each group was comprised of 15 rabbits (30 eyes); the latter 3 groups were the transient high IOP models. The retinal tissue around the papilledema was separated. Hematoxylin and eosin (HE) staining was carried out to generate slices for light microscopy. The changes in the retina thickness values of each layer were measured for all animals in each group at different postoperative recovery periods and compared with the values recorded for the animals in the control group. The thickness of the retinal tissue showed a normal distribution. The ANOVA was performed by using SPSS13.0 statistic *** the comparison between the 20s and 45s negative-pressure suction groups and the control group, no significant differences were observed, except at 14d. Significant difference was observed between the 3min negative-pressure suction group and the control group, and the retina thickness value of each layer reached a peak at 14d after *** negative suction during LASIK may not lead to significant changes in retinal tissue thickness; however, if the suction duration is increased to 3min, it will cause significant changes in retinal tissue thickness.

关键词： laser in situ keratomileusis transient high intraocular pressure retina thickness

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Comparison of Intraocular Pressures at Different Points in Human's Cornea before and after laser in situ keratomileusis with Tono-Pen Tonometer

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2011年第1期31卷 128-130页

作者：李新宇李贵刚刘磊栗静 Department of Ophthalmology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

In order to explore the difference of intraocular pressure（IOP） at different points of cornea before and after laser in situ keratomileusis（LASIK）,IOP was measured by Tono-Pen Tonometer at central cornea,pericentral cornea and limbus respectively and analyzed *** LASIK,IOP was dropped significantly at central cornea and pericentral cornea（P〈0.05）,while no statistically significant change occurred at limbus（P〉0.05）.There was no statistically significant difference in IOP at different points before LASIK（F=0.110,P=0.896）,but statistically significant difference was found after LASIK（F=7.375,P=0.001）.It was suggested that reliable IOP after LASIK could be obtained from the limbus by Tono-Pen tonometer.

关键词： Tono-Pen tonorneter laser in situ keratomileusis cornea intraocular pressure

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Effect of laser in situ keratomileusis on Accommodation

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2008年第5期28卷 596-598页

作者：刘磊袁菁栗静李新宇王渝龙 Refractive Surgery Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

The accommodative function before and after laser in situ keratomileusis （LASIK） was observed, and the effect of LASIK on accommodation was investigated. In a prospective clinical trial, 48 myopic patients （96 eyes） subject to bilateral LASIK in Refractive Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology （China） from March 2006 to June 2006 were selected and studied. Refractions, accommodative range, amplitude of accommodative response and high frequency component （HFC） of accommodative microfluctuations were measured with NEDIK-730A before and one week and 30 days after operation. Dominant and non-dominant eyes were determined by hole-in-card method. It was found that all of the operative eyes showed an uncorrected visual acuity of 0.8 or better one week postoperatively, and 1.0 or better 30 days postoperatively. Compared with those preoperatively, accommodative range and HFC had no significant difference at first week and 30th day after operation in both dominant eyes and non-dominant eyes （P〉0.05）, but there was a significant difference in the amplitude of accommodative response/accommodative stimulus ratio （A/S） after operation （P〈0.01）, and no significant difference was found in accommodation between one week and 30 days postoperation. No ocular dominance＇s change was noted. There was no significant difference in accommodative function between dominant eyes and non-dominant eyes. It was suggested that LASIK produced no significant effect on accommodation.

关键词： laser in situ keratomileusis accommodation dominant eye

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Corneal flap morphological analysis using anterior segment optical coherence tomography in laser in situ keratomileusis with femtosecond lasers versus mechanical microkeratome

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International Journal of Ophthalmology(English edition) 2012年第1期5卷 69-73页

作者： Xiao-Xiao Zhang Xing-Wu Zhong Jun-Shu Wu Zheng Wang Ke-Ming Yu Quan Liu and Bin Yang Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology Sun Yat-sen University Guangzhou 510060 Guangdong Province China

AIM: To assess and compare the flap morphology using anterior segment optical coherence tomography (AS-OCT) in laser in situ keratomileusis (LASIK) with Femto LDV femtosecond lasers versus Hansatome mechanical Microkeratome. METHODS: AS-OCT (Visante) was used to compare 1 month postoperatively the morphology of the flaps created with Femto LDV femtosecond lasers or Hansatome Microkeratome. The intendedfiap thickness was 110 mu m and 160 mu m respectively. The thickness of twenty-five points across each flap, which were 0mm, 1.5mm, 2.5mm, and 3.5mm to the corneal vertex on the horizontal, vertical, 45 degrees and 135 degrees meridian respectively, was evaluated. RESULTS: One month postoperative, the central flap thickness in the Femto LDV group was 107.43 +/- 4.70 mu m, while 125.90 +/- 17.50 mu m in the Hansatome group. The difference between the actual and the expectedfiap thickness was 5.61 +/- 3.84 mu m and 31.52 +/- 12.27 mu m, respectively. The Hansatome group had presented a statistically significant result (Plaser were more accurate and regular than the flaps created with Hansatome microkeratome.

关键词： AS-OCT laser in situ keratomileusis flap femtosecond laser

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Analysis of Macular and Retinal Nerve Fiber Layer Thickness in Children with Refractory Amblyopia after Femtosecond laser-assisted laser in situ keratomileusis：A Retrospective Study

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Chinese Medical Journal 2017年第18期130卷 2234-2240页

作者： Peng-Fei Zhao Yue-Hua Zhou Jing Zhang Wen-Bin Wei Beijing Tongren Eye Center Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Hospital Capital Medical University Beijing 100730 China

Background：Localized macular edema and retinal nerve fiber layer （RNFL） thinning have been reported shortly after laser in situ keratomileusis （LASIK） in ***,it is still unclear how LASIK affects the retina of *** study aimed to investigate the macular retina and RNFL thickness in children with refractive amblyopia who underwent femtosecond laser-assisted LASIK （FS-LASIK）.Methods：In this study,we included 56 eyes of 32 patients with refractive amblyopia who underwent FS-LASIK in our hospital from January 2012 to December *** （foveal center retinal,parafoveal retinal,and perifoveal）,macular inner retinal （superior and inferior）,and peripapillary RNFL thicknesses （superior,inferior,temporal,and nasal） were measured using Fourier-domain optical coherence tomography before surgery and l day,3 days,and 1 week after *** divided these patients into three groups based on their refractive error：High myopic group with 22 eyes （equivalent sphere,〉6.00 D）,mild myopic group with 19 eyes （equivalent sphere,0-6.00 D）,and hyperopic group with 15 eyes （equivalent sphere,〉＋0.50 D）.We compared the macular retina and RNFL thickness before and after LASIK.A paired simple t-test was used for data ***：One week after surgery,the visual acuity for all 56 eyes of the 32 patients reached their preoperative best-corrected *** acuity improved two lines or better for 31% of the *** residual refractive errors in 89% of the patients were within ±0.5 *** the high myopic group,the foveal center retinal and parafoveal retinal thicknesses were thicker 1 day and 3 days after surgery than before surgery （t =2.689,P =0.012;t =2.383,P =0.018,respectively）;no significant difference was found 1 week after surgery （P 〉 0.05）.The foveal center retinal and parafoveal retinal thicknesses were greater 1 day after surgery than they were before surgery （P =0.000 and P =0.005,respectively） in the mild myopic and hyperopic *** significant dif

关键词： Child laser in situ keratomileusis Optical Coherence Tomography Retinal

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Bilateral nontuberculous mycobacterial keratitis after laser in situ keratomileusis

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Chinese Medical Journal 2007年第21期120卷 1935-1937页

作者： LIANG Qing-feng SUN Xu-guang LI Ying WANG Zhi-qun LUO Shi-yun LI Ran Department of Ocular Microbiology Beijing Institute of Ophthalmology Beijing Tong Ren Hospital Capital Medical University Beijing 100005 China Department of Ophthalmology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

laser in situ keratomileusis （LASIK） is currently the most popular keratorefractive procedure performed worldwide with generally excellent outcomes. However, infectious keratitis after LASIK is a devastating, vision-threatening complication. The common pathogens were bacteria and fungi. Nontuberculous mycobacterium （NTM） accounted for a substantial proportion of these pathogens. Most NTM infections （86% of cases） were involved in unilateral cornea. In this study, we report six patients with bilateral NTM keratitis following LASIK.

关键词： laser in situ keratomileusis nontuberculous mycobacterium keratitis

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A clinical trial of premedication for unscheduled laser in situ keratomileusis surgeries and a related bacteriological analysis of conjunctival sacs

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Chinese Medical Journal 2014年第20期127卷 3669-3671页

作者： Yin Yi Zhao Lu Wang Xiaolei Wang Yanling Department of Ophthalmology Beijing Friendship Hospital CapitalMedical University Beijing 100050 China

laser in situ keratomileusis （LASIK） is a quick and effective approach for treating ametropia. It is used to treat relatively healthy corneas, and patients usually have high expectations and requirements for postoperative visual results. Therefore, the prevention of severe postoperative complications, such as corneal infections, is important.~ In China, some individuals require a rapid improvement in uncorrected visual acuity through surgery. There are also individuals from other cities seeking better medical services. Because of time limitations, the preoperative preparation time may be too short to complete a 3-day eye drop treatment with antibiotics. In this case study, we compared the bacterial eliminating effects and adverse reactions of levofloxacin eye drops （Santen Corp., Japan） and 0.5% Povidone-iodine （PVI, Nanda Pharmaceutical Corp., China） irrigation, for different time periods before unscheduled LASIK surgery.

关键词： levofloxacin povidone-iodine bacteria laser in situ keratomileusis conjunctiva

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