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Mucosal blood flow measurements using laser doppler perfusion monitoring

World Journal of Gastroenterology 2009年第2期15卷 198-203页

作者： Dag Arne Lihaug Hoff Hans Gregersen Jan Gunnar Hatlebakk Institute of Medicine University of Bergen NO-5021 Bergen Norway National Centre for Ultrasound in Gastroenterology Department of Medicine Haukeland University Hospital NO-5021 Bergen Norway Deparment of Medicine Aalesund Hospital Aalesund Norway Mech-Sense Aalborg Hospital 9000 Aalborg Denmark

perfusion of individual tissues is a basic physiological process that is necessary to sustain oxygenation and nutrition at a cellular level. Ischemia, or the insuff iciency of perfusion, is a common mechanism for tissue death or degeneration, and at a lower threshold, a mechanism for the generation of sensory signalling including pain. It is of considerable interest to study perfusion of pe- ripheral abdominal tissues in a variety of circumstances. Microvascular disease of the abdominal organs has been implicated in the pathogenesis of a variety of disorders, including peptic ulcer disease, inflammatory bowel disease and chest pain. The basic principle of laser doppler perfusion monitoring (LDPM) is to analyze changes in the spectrum of light reflected from tissues as a response to a beam of monochromatic laser light emitted. It reflects the total local microcirculatory blood perfusion, including perfusion in capillaries, arterioles, venules and shunts. During the last 20-25 years, numerous studies have been performed in different parts of the gastroin-testinal (GI) tract using LDPM. In recent years we have developed a multi-modal catheter device which includes a laser doppler probe, with the intent primarily to investigate patients suffering from functional chest pain of presumed oesophageal origin. Preliminary studies show the feasibility of incorporating LDPM into such catheters for performing physiological studies in the GI tract. LDPM has emerged as a research and clinical tool in preference to other methods; but, it is important to be aware of its limitations and account for them when reporting results.

关键词： laser doppler perfusion monitoring Gastrointestinal tract Mucosal blood flow perfusion Chest pain

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