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Laryngopharyngeal reflux disease:Updated examination of mechanisms,pathophysiology,treatment,and association with gastroesophageal reflux disease

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World Journal of Gastroenterology 2024年第16期30卷 2209-2219页

作者： Na Cui Ting Dai Yang Liu Ya-Yu Wang Jia-Yu Lin Qing-Fan Zheng Dong-Dong Zhu Xue-Wei Zhu Department of Otorhinolaryngology Head and Neck Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Ultrasound China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Gastroenterology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

Laryngopharyngeal reflux disease(LPRD)is an inflammatory condition in the laryngopharynx and upper aerodigestive tract mucosa caused by reflux of stomach contents beyond the *** commonly presents with symptoms such as hoarseness,cough,sore throat,a feeling of throat obstruction,excessive throat *** complex condition is thought to involve both reflux and reflex mechanisms,but a clear understanding of its molecular mechanisms is still ***,there is no standardized diagnosis or treatment *** strategies for LPRD mainly include lifestyle modifications,proton pump inhibitors and endoscopic *** paper seeks to provide a comprehensive overview of the existing literature regarding the mechanisms,pathophysiology and treatment of *** also provide an in-depth exploration of the association between LPRD and gastroesophageal reflux disease.

关键词： Laryngopharyngeal reflux Gastroesophageal reflux Head neck surgery laryngitis Otolaryngology

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Treatment of laryngopharyngeal reflux disease: A systematic review

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World Journal of Clinical Cases 2019年第19期7卷 2995-3011页

作者： Jerome R Lechien Francois Mouawad Maria R Barillari Andrea Nacci Seyyedeh Maryam Khoddami Necati Enver Sampath Kumar Raghunandhan Christian Calvo-Henriquez Young-Gyu Eun Sven Saussez Laboratory of Anatomy and Cell Biology Faculty of MedicineUMONS Research Institute for Health Sciences and TechnologyUniversity of MonsMons 7000Belgium Laryngopharyngeal Reflux Study Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies Paris 75000France Department of Otolaryngology-Head and Neck Surgery CHU de LilleLille 59000France Division of Phoniatrics and Audiology Department of Mental and Physical Health and Preventive MedicineUniversity of L.VanvitelliNaples 80100Italy ENT Audiology and Phoniatric Unit University of PisaPisa 56100Italy Larynx Function and Acoustic Voice Laboratory Department of Speech TherapySchool of RehabilitationTehran 11369Iran Department of Otolaryngology Marmara University Pendik Training and Research HospitalIstanbul 34722Turkey Department of Otology Neurotology and Skullbase SurgeryMadras ENT Research FoundationTamil Nadu 60028India Department of Otorhinolaryngology and Head and Neck Surgery Hospital Complex of Santiago de CompostelaSantiago de Compostela 15700Spain Department of Otorhinolaryngology and Head and Neck Surgery Kyung Hee University Medical CenterSeoul 130702Korea

BACKGROUNG For a long time,laryngopharyngeal reflux disease(LPRD)has been treated by proton pump inhibitors(PPIs)with an uncertain success *** To shed light the current therapeutic strategies used for LPRD in order to analysis the rationale in the LPRD *** Three authors conducted a PubMed search to identify papers published between January 1990 and February 2019 about the treatment of *** prospective or retrospective studies had to explore the impact of medical treatment(s)on the clinical presentation of suspected or confirmed *** criteria for considering studies for the review were based on the population,intervention,comparison,and outcome *** The search identified 1355 relevant papers,of which 76 studies met the inclusion criteria,accounting for 6457 patients.A total of 64 studies consisted of empirical therapeutic trials and 12 were studies where authors formally identified LPRD with pH-monitoring or multichannel intraluminal impedance-pH monitoring(MII-pH).The main therapeutic scheme consisted of once or twice daily PPIs for a duration ranged from 4 to 24 *** most used PPIs were omeprazole,esomeprazole,rabeprazole,lansoprazole and pantoprazole with a success rate ranging from 18%to 87%.Other composite treatments have been prescribed including PPIs,alginate,prokinetics,and H2 Receptor *** Regarding the development of MII-pH and the identification of LPRD subtypes(acid,nonacid,mixed),future studies are needed to improve the LPRD treatment considering all subtypes of reflux.

关键词： Laryngopharyngeal Reflux laryngitis Treatment Proton pump inhibitors

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Gastroesophageal reflux disease and the airway-essentials for the surgeon

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World Journal of Gastrointestinal Surgery 2009年第1期1卷 8-10页

作者： Vic Velanovich Division of General Surgery Henry Ford HospitalDetroit

Gastroesophageal reflux disease(GERD) has many protean *** of the most vexing have to do with the *** affects the tracheobronchial tree directly,leading to aspiration pneumonia and asthma,or exacerbating existing pulmonary disease,such as asthma or chronic obstructive pulmonary *** addition to the respiratory manifestation of GERD,there are unique pharyngeal and laryngeal *** include voice hoarseness,throat-clearing,chronic cough,globus,and "post-nasal drip".Linking these symptoms to GERD is challenging and frequently the diagnosis is that of *** proton pump inhibitor therapy being the mainstay of treatment,with anti-reflux surgery being reserved for intractable cases,there is no definitive evidence of the superiority of either.

关键词： Gastroesophageal reflux disease Laryngo-pharyngeal reflux Reflux-induced asthma Aspiration pneumonia Chronic obstructive pulmonary disease Chronic cough Reflux laryngitis

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