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large-sized bone defect repair by combining a decalcified bone matrix framework and bone regeneration units based on photo-crosslinkable osteogenic microgels

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Bioactive Materials 2022年第8期7卷 97-109页

作者： Junxiang Hao Baoshuai Bai Zheng Ci Jincheng Tang Guanhuai Hu Chengxiang Dai Mengyuan Yu Meng Li Wei Zhang Yixin Zhang Wenjie Ren Yujie Hua Guangdong Zhou Research Institute of Plastic Surgery Weifang Medical UniversityWeifangShandongChina Department of Plastic and Reconstructive Surgery Shanghai 9th People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Tissue EngineeringShanghaiChina National Tissue Engineering Center of China ShanghaiChina Institute of Regenerative Medicine and Orthopedics Institutes of Health Central PlainXinxiang Medical UniversityXinxiangHenanChina Cellular Biomedicine Group Inc.ShanghaiChina

Physiological repair of large-sized bone defects is great challenging in clinic due to a lack of ideal grafts suitable for bone *** bone matrix(DBM)is considered as an ideal bone regeneration scaffold,but low cell seeding efficiency and a poor osteoinductive microenvironment greatly restrict its application in large-sized bone *** address these problems,we proposed a novel strategy of bone regeneration units(BRUs)based on microgels produced by photo-crosslinkable and microfluidic techniques,containing both the osteogenic ingredient DBM and vascular endothelial growth factor(VEGF)for accurate biomimic of an osteoinductive *** physicochemical properties of microgels could be precisely controlled and the microgels effectively promoted adhesion,proliferation,and osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)in *** were successfully constructed by seeding BMSCs onto microgels,which achieved reliable bone regeneration in ***,by integrating the advantages of BRUs in bone regeneration and the advantages of DBM scaffolds in 3D morphology and mechanical strength,a BRU-loaded DBM framework successfully regenerated bone tissue with the desired 3D morphology and effectively repaired a large-sized bone defect of rabbit *** current study developed an ideal bone biomimetic microcarrier and provided a novel strategy for bone regeneration and large-sized bone defect repair.

关键词： Microgels large-sized bone defect repair bone regeneration units Photo-crosslinking Decalcified bone matrix

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Methacrylated gelatin and platelet-rich plasma based hydrogels promote regeneration of critical-sized bone defects

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Regenerative Biomaterials 2024年第4期3卷 66-81页

作者： Shichao Lian Zhiyu Mu Zhengchao Yuan Muhammad Shafiq Xiumei Mo Weidong Mu Department of Traumatic Orthopaedics Shandong Provincial HospitalShandong UniversityJinanShandong 250012China Zoucheng People’s Hospital ZouchengShandong 273500China Department of Medical Physics and Biomedical Engineering University of LondonLondon WC1E 6BTUK State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620PR China Innovation Center of NanoMedicine(iCONM) Kawasaki Institute of Industrial PromotionKawasaki-KuKawasaki 210-0821Japan

Physiological repair of large-sized bone defects requires instructive scaffolds with appropriate mechanical properties,biocompatibility,biodegradability,vasculogenic ability and *** objective of this study was to fabricate in situ injectable hydrogels using platelet-rich plasma(PRP)-loaded gelatin methacrylate(GM)and employ them for the regeneration of large-sized bone *** performed various biological assays as well as assessed the mechanical properties of GM@PRP hydrogels alongside evaluating the release kinetics of growth factors(GFs)from *** GM@PRP hydrogels manifested sufficient mechanical properties to support the filling of the tissue *** biofunction assay,the GM@PRP hydrogels significantly improved cell migration and ***,transcriptome RNA sequencing of human umbilical vein endothelial cells and bone marrow-derived stem cells were performed to delineate vascularization and biomineralization abilities of GM@PRP *** GM@PRP hydrogels were subcutaneously implanted in rats for up to 4 weeks for preliminary biocompatibility followed by their transplantation into a tibial defect model for up to 8 weeks in *** defects treated with GM@PRP hydrogels manifested significant bone regeneration as well as angiogenesis,biomineralization,and collagen *** on the biocompatibility and biological function of GM@PRP hydrogels,a new strategy is provided for the regenerative repair of large-size bone defects.

关键词： large-sized bone defect repair platelet-rich plasma hydrogel tissue scaffold gelatin methacrylate

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