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Mimicking the native bone regenerative microenvironment for in situ repair of large physiological and pathological bone defects

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Engineered Regeneration 2022年第4期3卷 440-452页

作者： Pei Wang Xiansong Wang Department of Plastic and Reconstructive Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Thoracic surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

bone is a complex biological tissue with a complicated hierarchical nanocomposite *** native microen-vironment of the bone tissue may be significantly disrupted by large physiological and pathological bone *** defects are often treated via complex surgical procedures that involve the application of autografts or *** these grafting procedures often suffer from insufficient natural bone stock and ***,these traditional treatment methods fail to simulate a regenerative microenvironment,which plays a significant role in regeneration of bone tissue and repair of large bone *** this end,various biomimetic scaffolds have been devised to mimic the native microenvironment of bone and thereby to simultaneously re-pair bone defects and promote bone *** propose here a novel concept,in vivo bone regenerative microenvironment(BRM),which enables repair of large bone defects and enhances new bone tissue formation with external *** this review,we mainly focus on materials and methods for fabrication of biomimetic scaffolds,as well as their therapeutic efficacy in modulating the BRM of large physiological and pathological bone defects.

关键词： bone regenerative microenvironemt(BRM) large physiological bone defects large pathological bone defects Biomaterial Scaffold

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