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Platelet rich plasma effectiveness in bowel anastomoses:A systematic review

World Journal of Gastrointestinal Surgery 2021年第12期13卷 1736-1753页

作者： Georgios Geropoulos Kyriakos Psarras Dimitrios Giannis Eirini Chrysovalantou Martzivanou Maria Papaioannou Christos Dimitrios Kakos Efstathios Theodoros Pavlidis Nikolaos Symeonidis Georgios Koliakos Theodoros Efstathios Pavlidis Department of General Surgery University College London HospitalsLondon NW12BUUnited Kingdom Laboratory of Scientific Research and Experimental Surgery 2nd Propedeutic Department of SurgerySchool of MedicineAristotle UniversityThessaloniki 54642Greece Surgery Working Group Society of Junior DoctorsAthens 15123Greece Institute of Health Innovations and Outcomes Research Feinstein Institutes for Medical ResearchManhassetNY 11030United States Laboratory of Biological Chemistry School of MedicineFaculty of Health SciencesAristotle University of ThessalonikiThessaloniki 54124Greece

BACKGROUND Anastomotic leak constitutes a major problem in abdominal *** insufficiency,topical or systemic factors contribute to disrupted healing of the performed bowel anastomosis and result in anastomosis leakage,with detrimental effects on patient postoperative *** the investigation of several factors and the invention of protective materials,the ideal agent to prevent anastomotic leaks is yet to be *** To study the effect of platelet rich plasma(PRP)on the healing of bowel *** A systematic literature search was performed in PubMed,EMBASE,and Scopus databases to identify studies investigating the effect of PRP application on bowel *** Eighteen studies were eligible with a total population of 712 animals including rats(14 studies),rabbits(2 studies)and pigs(2 studies).No postoperative complications were reported following PRP *** out of 18 studies reported a statistically significant higher anastomosis bursting pressure in PRP groups compared to control either in healthy animals or animal models with underlying condition or intervention,such as intraperitoneal chemotherapy or *** results were reported by ten studies in terms of tissue hydroxyproline *** study reported significant increase in collagen deposition in PRP *** application resulted in significantly decreased inflammatory cell infiltration in the presence of peritonitis or intraperitoneal chemotherapy(6 studies).CONCLUSION The application of PRP is associated with improved bowel anastomosis outcomes,especially in animal models having an underlying condition affecting the normal healing *** application seems to augment the normal healing process under these ***,further studies are needed to investigate the potential role of PRP on bowel anastomosis healing,especially in clinical settings.

关键词： Platelet rich plasma Colonic anastomosis Small bowel anastomosis large bowel anastomosis bowel anastomosis Surgery

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