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Characteristics of language impairment in Parkinson’s disease and its influencing factors

Translational Neurodegeneration 2015年第1期4卷 9-16页

作者： Lin Liu Xiao-Guang Luo Chui-Liang Dy Yan Ren Yu Feng Hong-Mei Yu Hong Shang Zhi-Yi He Neurology Department of First Affiliated Hospital of China Medical University 155 Nanjing Bei StreetHeping DistrictShenyang 110001China Department of Laboratory Medicine of First Affiliated Hospital of China Medical University 155 Nanjing Bei StreetHeping DistrictShenyang 110001China

Background:language impairment is relatively common in Parkinson’s disease(PD),but not all PD patients are susceptible to language *** this study,we identified among a sample of PD patients those pre-disposed to language impairment,describe their clinical profiles,and consider factors that may precipitate language disability in these ***:A cross-sectional cohort of 31 PD patients and 20 controls were administered the Chinese version of the Western Aphasia Battery(WAB)to assess language abilities,and the Montreal Cognitive Assessment(MoCA)to determine cognitive *** patients were then apportioned to a language-impaired PD(LI-PD)group or a PD group with no language impairment(NLI-PD).Performance on the WAB and MoCA was investigated for correlation with the aphasia quotient deterioration rate(AQDR).Results:The PD patients scored significantly lower on most of the WAB subtests than did the *** aphasia quotient,cortical quotient,and spontaneous speech and naming subtests of the WAB were significantly different between LI-PD and NLI-PD *** AQDR scores significantly and positively correlated with age at onset and motor function ***:A subset group was susceptible to language dysfunction,a major deficit in spontaneous *** established,dysphasia progression is closely associated with age at onset and motor disability progression.

关键词： Aphasia quotient language function deterioration rate language impairment Parkinson’s disease,Western aphasia battery

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