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Interfacial properties and micellization of triblock poly(ethylene glycol)-poly(ε-caprolactone)-polyethyleneimine copolymers

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Acta Pharmaceutica Sinica B 2020年第6期10卷 1122-1133页

作者： Ji Li Yitian Du Haitao Su Shixuan Cheng Yanxia Zhou Yiguang Jin Xian-Rong Qi Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China

This study aimed to explore the link between block copolymers’interfacial properties and nanoscale carrier formation and found out the influence of length ratio on these characters to optimize drug delivery system.A library of diblock copolymers of PEG-PCL and triblock copolymers with additional PEI(PEG-PCL-PEI)were ***,a systematic isothermal investigation was performed to explore molecular arrangements of copolymers at air/water ***,structural properties and drug encapsulation in self-assembly were investigated with DLS,SLS and *** found the additional hydrogen bond in the PEG-PCL-PEI contributes to film stability upon the hydrophobic interaction compared with ***-PCL-PEI assemble into smaller micelle-like(such as PEGPCL4006-PEI)or particle-like structure(such as PEG-PCL8636-PEI)determined by their hydrophilic and hydrophobic block *** distinct structural architectures of copolymer are consistent between interface and *** the disparity of constituent ratio,we discovered the arrangement of both chains guarantees balanced hydrophilic-hydrophobic ratio in self-assembly to form stable ***,the structural differences were found to have significant influence on model drugs incorporation including docetaxel and *** together,these findings indicate the correlation between molecular arrangement and self-assembly and inspire us to tune block compositions to achieve desired nanostructure and drug loading.

关键词： Block copolymers langmuir films Molecular arrangement Self-assembly Nanostructure

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Synthesis of Novel Amphiphilic Poly(ester-amine) Dendrimers and Their Recognition of Hg^(2+) at the Air/Water Interface

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Chinese Journal of Chemistry 2003年第8期21卷 1011-1014页

作者：申亮李富友沙耀武潘峥峥洪啸吟黄春辉 Department of Chemistry Tsinghua University State Key Laboratory of Rare Earth Materials Chemistry and Applications Peking University

Two novel amphiphilic poly(ester amine) dendrimers were synthesized and characterized by 1H NMR, 13 C NMR and IR spectra. Their properties of langmuir film were investigated at the air/water interface. The relationship between the surface pressure and area isotherms of the dendrimers was found to be dependent on the nature of subphases. Interaction between HgCl 2 and the dendrimers was observed, indicating that the amphiphilic dendrimers could act as a sensor for Hg 2+ .

关键词： amphiphilic poly(ester amine) dendrimer langmuir films ion recognition

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