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Relationship between glycemic variability and cognitive function in lacune patients with type 2 diabetes

World Journal of Clinical Cases 2023年第5期11卷 1019-1030页

作者： Qi-Zhe Meng Yang Wang Bing Li Zhi Xi Ming Wang Jia-Qi Xiu Xiao-Peng Yang Department of Neurology The Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450003Henan ProvinceChina

BACKGROUND lacunes are the manifestations of lacunar infarction which can lead many patients to the clinical outcome of disability or ***,the relationship between lacune burden,cognitive function and blood glucose fluctuation in patients with type 2 diabetes mellitus(T2DM)complicated with lacunes is not very *** To explore the correlation between glucose variability,lacune burden and cognitive function in patients with lacunes complicated with *** The clinical and imaging data of 144 patients with lacunes combined with T2DM were reviewed retrospectively.72 h continuous glucose monitoring was *** Montreal Cognitive Assessment was used to assess cognitive *** burden of lacunes was evaluated using magnetic resonance imaging *** logistic regression analysis was used to study the affecting the lacune load and cognitive impairment in *** predict the value of patients’cognitive impairment with lacunes complicated with T2DM,a receiver operating characteristic(ROC)curve and a nomogram prediction model were *** The standard deviation(SD)of the average blood glucose concentration,percentage coefficient of variation(%CV)and time of range(TIR)were significantly different between the low and the high load groups(Placunes patients complicated with ***(OR:0.874,95%CI:0.833-0.928,Placunes complicated with T2DM,TIR(OR:0.957,95%CI:0.922-0.994,P<0.05)is a protective factor.A nomogram prediction model o

关键词： Blood glucose variability lacunes Type 2 diabetes Cognitive impairment Nomograms

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