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lactiplantibacillus plantarum l47 and inulin alleviate enterotoxigenic Escherichia coli induced ileal inflammation in piglets by upregulating the levels of a-linolenic acid and 12,13-epoxyoctadecenoic acid

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Animal Nutrition 2023年第3期14卷 370-382页

作者： leihong Cui Hui Zeng Meixin Hou Zhongxin li Chunlong Mu Weiyun Zhu Suqin Hang National Center for International Research on Animal Gut Nutrition Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal HealthLaboratory of Gastrointestinal MicrobiologyNanjing Agricultural UniversityNanjing 210095China

Alternatives to antibiotics for preventing bacteria-induced inflammation in early-weaned farm animals are sorely needed. Our previous study showed that lactiplantibacillus plantarum l47 and inulin could alleviate dextran sulfate sodium(DSS)-induced colitis in mice. To explore the protective effects of l. plantarum l47 and inulin on the ileal inflammatory response in weaned piglets challenged with enterotoxigenic Escherichia coli(ETEC), 28 weaned piglets were assigned into four groups, namely, CON group—orally given 10 ml/d phosphate buffer saline(PBS), lI47 group—orally given a mixture of 10 m l/d l. plantarum l47 and inulin, ECON group—orally given 10 ml/d PBS and challenged by ETEC, and ElI47group—orally given 10 ml/d l. plantarum l47 and inulin mixture and challenged by ETEC. The results demonstrated that the combination of l. plantarum l47 and inulin reduced inflammatory responses and relieved the inflammatory damage caused by ETEC, including ileal morphological damage, reduced protein expression of ileal tight junction, decreased antioxidant capacity, and decreased antiinflammatory factors. Transcriptome analysis revealed that l. plantarum l47 and inulin up-regulated the gene expression of phospholipase A2 group IIA(PlA2G2A)(P ll as affected alphalinolenic acid(AlA) metabolism and linoleic acid metabolism. Moreover, l. plantarum l47 and inulin increased the levels of AlA(P lipoteichoic acid(lTA)(P ll-like receptor 2(TlR2)(P = 0.05) in the ileal mucosa. In conclusion, l. plantarum l47 and inulin together alleviated ETEC-induced ileal inflammation in piglets by up-regulating the levels of AlA and 12,13-EpOME via the lTA/TlR2/PlA2G2A pathway.

关键词： lactiplantibacillus plantarum l47 Inulin Enterotoxigenic Escherichia coli Ileal inflammation Piglet Phospholipase A2 group IIA

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