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Increased levels of lactate dehydrogenase and hypertension are associated with severe illness of COVID-19

World Journal of Clinical Cases 2022年第1期10卷 128-135页

作者： Zhen-Mu Jin Ji-Chan Shi Mo Zheng Que-Lu Chen Yue-Ying Zhou Fang Cheng Jing Cai Xian-Gao Jiang Department of Rheumatology Immunology and AllergyWenzhou Central HospitalThe Second Affiliated Hospital of Shanghai UniversityAffiliated Dingli Clinical Institute of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Infectious Diseases Wenzhou Central HospitalThe Second Affiliated Hospital of Shanghai UniversityAffiliated Dingli Clinical Institute of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Radiology Wenzhou Central HospitalThe Second Affiliated Hospital of Shanghai UniversityAffiliated Dingli Clinical Institute of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Coronavirus disease 2019(COVID-19)is amid an ongoing pandemic.It has been shown that patients with cardiovascular comorbidities are at higher risk of severe illness of COVID-19.AIM To find out the relationship between cardiovascular comorbidities and severe illness of COVID-19.METHODS The clinical data of 140 COVID-19 patients treated from January 22,2020 to March 3,2020 at our hospital were retrospectively collected.The clinical characteristics were compared between patients with mild illness and those with severe illness.RESULTS There were 75 male patients and 65 female patients(53.6%vs 46.4%).The mean age was 45.4±14.6 years(range,2-85 years).Most of the patients had mild illness(n=114,81.4%)and 26 patients had severe illness(18.6%).The most common symptom was fever(n=110,78.6%),followed by cough(n=82,58.6%)and expectoration(n=51,36.4%).Eight patients were asymptomatic but were positive for severe acute respiratory syndrome coronavirus 2 RNA.Patients with severe illness were significantly more likely to be hypertensive than those with mild illness[(10/26,38.4%)vs(22/114,19.3%),P=0.036].The levels of lactate dehydrogenase were significantly higher in the severe illness group than in the mild illness group(299.35±68.82 vs 202.94±63.87,Plactate dehydrogenase may be associated with severe illness of COVID-19.

关键词： Pneumonia Virus COVID-19 Hypertension lactate dehydrogenase Radiology

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Glucose metabolic reprogramming-related parameters for the prediction of 28-day neurological prognosis and all-cause mortality in patients after cardiac arrest:a prospective single-center observational study

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World Journal of Emergency Medicine 2024年第3期15卷 197-205页

作者： Subi Abudurexiti Shihai Xu Zhangping Sun Yi Jiang Ping Gong Department of Emergency Medicine Ruijin Hospital Affi liated to Shanghai Jiaotong University School of MedicineShanghai 200025China Department of Emergency Medicine Shenzhen People's Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affi liated HospitalSouthern University of Science and Technology)Shenzhen 518020China Department of Emergency Medicine the First Affi liated Hospital of Dalian Medical UniversityDalian 116011China Department of Emergency Medicine General Hospital of Tianjin Medical UniversityTianjin 300052China

BACKGROUND:We aimed to observe the dynamic changes in glucose metabolic reprogrammingrelated parameters and their ability to predict neurological prognosis and all-cause mortality in cardiac arrest patients after the restoration of spontaneous circulation(ROSC).METHODS:Adult cardiac arrest patients after ROSC who were admitted to the emergency or cardiac intensive care unit of the First Aflliated Hospital of Dalian Medical University from August 1,2017,to May 30,2021,were enrolled.According to 28-day survival,the patients were divided into a non-survival group(n=82) and a survival group(n=38).Healthy adult volunteers(n=40) of similar ages and sexes were selected as controls.The serum levels of glucose metabolic reprogrammingrelated parameters(lactate dehydrogenase [LDH],lactate and pyruvate),neuron-specific enolase(NSE) and interleukin 6(IL-6) were measured on days 1,3,and 7 after ROSC.The Acute Physiology and Chronic Health Evaluation II(APACHE II) score and Sequential Organ Failure Assessment(SOFA) score were calculated.The Cerebral Performance Category(CPC) score was recorded on day 28 after ROSC.RESULTS:Following ROSC,the serum LDH(607.0 U/L vs.286.5 U/L),lactate(5.0 mmol/L vs.2.0 mmol/L),pyruvate(178.0 μmol/L vs.70.9 μmol/L),and lactate/pyruvate ratio(34.1 vs.22.1) significantly increased and were higher in the non-survivors than in the survivors on admission(all P<0.05).Moreover,the serum LDH,pyruvate,IL-6,APACHE II score,and SOFA score on days 1,3 and 7 after ROSC were significantly associated with 28-day poor neurological prognosis and 28-day all-cause mortality(all P<0.05).The serum LDH concentration on day 1 after ROSC had an area under the receiver operating characteristic curve(AUC) of 0.904 [95% confidence interval [95% CI]:0.851–0.957]) with 96.8% specificity for predicting 28-day neurological prognosis and an AUC of 0.950(95% CI:0.911–0.989) with 94.7% specificity for predicting 28-day all-cause mortality,which was the highest among the glucose metabolic reprogramming-related parameters tested.CONC

关键词： Glucose metabolic reprogramming lactate dehydrogenase Cardiac arrest Prognosis

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Testicular germ cell tumors type 2 have high RNA expression of LDHB,the gene for lactate dehydrogenase subunit B

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Asian Journal of Andrology 2021年第4期23卷 357-362页

作者： Finn Edler von Eyben Jorge Parraga-Alava Shi-Ming Tu Center for Tobacco Control Research Birkevej 17Odense M DK-5230Denmark Facultad de Ciencias Informáticas Universidad Técnica de ManabíPortoviejo 130105Ecuador Department of Informatics Engineering Santiago UniversitySantiago 917020Chile Department of Urology University of Texas MD Anderson Cancer Center1515 Holcombe BlvdHoustonTX 77030USA

This study analyzed RNA expression of genes for three serum tumor markers,alpha fetoprotein(AFP),human chorionic gonadotropin(hCG),and lactate dehydrogenase(LDH),in patients with testicular germ cell tumors(TGCT)type 2.The gene AFP encodes AFP,the gene for chorionic gonadotropin beta polypeptide 5(CGB5)encodes a major part of the specific beta subunit of hCG,and the genes for LDH subunit A(LDHA),LDH subunit B(LDHB),and LDH subunit C(LDHC)encode three different subunits of LDH.LDHB encodes the LDHB subunit present as a tetramer in LDH isoenzyme 1(LDH-1).We examined three datasets with 203 samples of normal testis tissue(NT)and TGCT type 2.Yolk sac tumor(YST)expressed RNA of AFP fourteen thousand times higher than seminoma(SE),embryonal carcinoma(EC),and teratoma(TER)combined(P=0.00015).In the second microarray,choriocarcinoma(CC)expressed RNA of CGB5 ten times higher than other histologic types of TGCT combined.EC expressed RNA of LDHB twice higher than SE,YST and TER combined(P=0.000041).EC expressed RNA of LDHB higher than that YST expressed RNA of AFP and that CC expressed RNA of CGB5.In conclusion,TGCT type 2 expressed RNA of LDHB markedly higher than the RNA of 23 other candidate genes for TGCT type 2.

关键词： alpha fetoprotein gene regulation human chorionic gonadotropin lactate dehydrogenase lactate dehydrogenase isoenzymes testicular germ cell tumors

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Lovastatin changes activities of lactate dehydrogenase A and B genes in rat myocardial cells

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Chinese Medical Journal 2011年第3期124卷 423-428页

作者： GUO Wei-zao JI Hong YAN Zhi-hong LI Lin LI Di LU Cui-lian Department of Geriatrics Aerospace Central Hospital Beijing 100049 China

Background lactate dehydrogenase （LDH） is a crucial regulator of energy metabolism in many organs including the heart. Lovastatin is widely used in prevention and treatment of coronary heart disease and is a drug with substantial metabolic influences. Our study aimed to determine the activities of the lactate dehydrogenase A and B （LDHA and LDHB）genes following lovastatin treatment.Methods The rat myocardial cell line H9c2（2-1） in culture was exposed to 100 nmol/L lovastatin for 24 hours or for five days. The functions of the LDHA and LDHB genes were examined at the transcriptional （mRNA） level with quantitative real-time polymerase chain reaction （Q-RT-PCR）, and at the translational （protein） level with immunoblotting.Results When compared with control levels, the LDHA mRNA went up by （151.65±16.72）% （P=0.0132） after 24 hours and by （175.28±56.54）% （P=0.0366） after five days of lovastatin treatment. Although 24 hours of lovastatin treatment had no significant effects on LDHB mRNA levels, when the treatment was extended to five days, LDHB mRNA levels were significantly down-regulated to （63.65±15.21）% of control levels （P=0.0117）. After 24 hours of treatment with lovastatin,there were no significant changes in protein levels of either LDHA or LDHB. When treatment time was extended to five days, the protein levels of LDHA were up-regulated by （148.65±11.81）% （P=0.00969）, while the protein levels of LDHB were down-regulated to （64.91±5.47）% of control levels （P=0.0192）.Conclusions Lovastatin affects gene activities of LDHA and LDHB differently, which may reveal novel pharmacological effects of lovastatin.

关键词： lovastatin lactate dehydrogenase coronary heart disease gene metabolism

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High serum lactate dehydrogenase and dyspnea:Positive predictors of adverse outcome in critical COVID-19 patients in Yichang

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World Journal of Clinical Cases 2020年第22期8卷 5535-5546页

作者： Xiao-Ting Lv Yong-Ping Zhu Ai-Guo Cheng Yong-Xu Jin Hai-Bo Ding Cai-Yun Wang Shu-Yu Zhang Gong-Ping Chen Qing-Quan Chen Qi-Cai Liu Department of Respiratory and Critical Care Medicine the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina Institute of Respiratory Disease Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Cardiovascular Surgery Fujian Medical University Attached Union HospitalFuzhou 350001Fujian ProvinceChina Department of Critical Medicine the Third People's Hospital of YichangYichang 443000Hubei ProvinceChina Department of Laboratory Medicine Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina Department of Reproductive Medicine Centre First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina

BACKGROUND Coronavirus disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)outbreak in China,constitutes a Public Health Emergency of International Concern.It is well known that COVID-19 patients may have increased serum lactate dehydrogenase(LDH)levels in the early stage.The clinical changes in LDH may have predictive value in disease evolution and prognosis in critically ill COVID-19 patients.AIM To examine serum LDH and clinical characteristics in patients with COVID-19 and their predictive value for prognosis.METHODS This retrospective study analyzed the clinical data of forty-seven critical COVID-19 patients in the intensive care unit of the Third People's Hospital of Yichang City from January 27 to March 25,2020 and divided them into survivors and nonsurvivors.The patients were diagnosed according to the World Health Organization interim guidance and critical cases met any one of the following criteria:Respiratory failure and required mechanical ventilation,the occurrence of shock,and the combined failure of other organs that required intensive care unit monitoring and treatments,according to the diagnostic criteria of critical COVID-19.Clinical data including symptoms,detection of SARS-CoV-2,chest computed tomography(CT)images,changes in serum LDH in different clinical phases,and prognosis were collected.Statistical analysis of the data was performed.Continuous variables were expressed as median(interquartile range)and compared with the Mann-Whitney U test.Categorical variables were compared with the Chi-square test.Survival data were analyzed using Kaplan-Meier survival curves and log-rank tests.RESULTS According to chest CT images,we observed the alveolitis and fibrosis stages in all critical patients in this study.Most non-survivors died in the fibrosis stage.Nonsurvivors had fewer days of hospitalization,shorter disease duration,shorter duration of alveolitis and fibrosis,and had dyspnea symptoms at disease onset(P=0.05).Both first and lowest LDH values in the

关键词： COVID-19 SARS-CoV-2 lactate dehydrogenase Pulmonary fibrosis Dyspnea Overall survival

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Systemic immune inflammation index, ratio of lymphocytes to monocytes, lactate dehydrogenase and prognosis of diffuse large Bcell lymphoma patients

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World Journal of Clinical Cases 2021年第32期9卷 9825-9834页

作者： Xiao-Bo Wu Shu-Ling Hou Hu Liu Department of Lymphoma Cancer CenterShanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuan 030032Shanxi ProvinceChina Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND In malignant tumors,inflammation plays a vital role in the development,invasion,and metastasis of cancer cells.Diffuse large B-cell lymphoma(DLBCL),the most common malignant proliferative disease of the lymphatic system,is commonly associated with inflammation.The international prognostic index(IPI),which includes age,lactate dehydrogenase(LDH),number of extranodal lesions,Ann Arbor score,and Eastern Cooperative Oncology Group(ECOG)score,can evaluate the prognosis of DLBCL.However,its use in accurately identifying highrisk patients and guiding treatment is poor.Therefore,it is important to find novel immune markers in predicting the prognosis of DLBCL patients.AIM To determine the association between the systemic immune inflammation index(SII),ratio of lymphocytes to monocytes(LMR),ratio of LMR to LDH(LMR/LDH),and prognosis of patients with DLBCL.METHODS A total of 68 patients diagnosed with DLBCL,treated in our hospital between January 2016 and January 2020,were included.χ2 test,Pearson’s R correlation,Kaplan Meier curves,and Cox proportional risk regression analysis were used.The differences in the SII,LMR,and LMR/LDH among patients with different clinicopathological features were analyzed.The differences in progression-free survival time among patients with different SII,LMR,and LMR/LDH expressions and influencing factors affecting the prognosis of DLBCL patients,were also analyzed.RESULTS The LMR and LMR/LDH in patients with Ann Arbor stage III–IV,ECOG score≥2,and SII,IPI score 2–5 were significantly higher than those of patients with Ann Arbor stage I-II and ECOG score<2(P<0.05).Patients with high SII,LMR,and LMR/LDH had progression-free survival times of 34 mo(95%CI:32.52–38.50),35 mo(95%CI:33.42–36.58)and 35 mo(95%CI:33.49–36.51),respectively,which were significantly lower than those with low SII,LMR,and LMR/LDH(P<0.05);the SII,LMR,and LMR/LDH were positively correlated(P<0.05).Cox proportional risk regression analysis showed that the SII,LMR,and LMR/LDH were influencing factors for the prognosi

关键词： Systemic immune inflammation index Ratio of lymphocytes to monocytes lactate dehydrogenase Diffuse large B-cell lymphoma Prognosis

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Changes of lactate dehydrogenase in corneal edema after cataract surgery treated with trans-corneal oxygenation therapy

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International Journal of Ophthalmology(English edition) 2020年第7期13卷 1148-1151页

作者： Eunike Amelina Lahagu Jajah Fachiroh Andreas Surya Anugrah Wasisdi Gunawan Indra Tri Mahayana Suhardjo Department of Ophthalmology Faculty of MedicinePublic Healthand NursingUniversitas Gadjah Mada-Dr.Sardjito General HospitalYogyakarta 55284Indonesia Department of Biomolecular and Cell Biology Faculty of MedicinePublic Healthand NursingUniversitas Gadjah MadaYogyakarta 55284Indonesia

AIM:To investigate the changes in levels of the lactate dehydrogenase(LDH)enzyme in corneal edema after cataract surgery with trans-corneal oxygenation therapy.METHODS:This pre-post design study design conducted on 15 patients with corneal edema after cataract surgery and receiving trans-corneal oxygenation therapy.Tear sample(using Schirmer paper,from the inferior fornix of the conjunctiva)was carried out prior to trans-corneal oxygenation therapy,on the day 2(D2)and day 5(D5)postoperatively before and after trans-corneal oxygenation therapy.Visual acuity[VA(Log MAR)],corneal endothelial density,central corneal thickness(CCT),and coefficient of variation corneal endothelial(Co V)were recorded.The value of LDH was measured using ELISA.The difference in mean LDH value before and after trans-corneal oxygenation therapy,between two groups were analyzed using Wilcoxon signed rank test.RESULTS:There was a decrease in LDH tear concentration at D2(pre vs post:1127.54±497.09 vs 696.91±489.49;P=0.002)and D5(pre vs post:1064.17±677.77 vs 780.28±428.95;P=0.027)after trans-corneal oxygenation therapy as well as decrease in LDH concentration on the D2 compared to D5(P=0.041).The mean CCT was decreased significantly after the administration of trans-corneal oxygenation(pre vs post:632.10±25.66 vs 563.90±51.54;P=0.005).The mean VA and Co V increased significantly after the administration of trans-corneal oxygenation(P=0.001 and P=0.028,respectively).However,there was no difference in mean of corneal endothelial density(P=0.814).CONCLUSION:Trans-corneal oxygenation therapy is associated with significant decrease of tears LDH levels in post cataract surgery with corneal edema.It is accompanied by clinical improvement such as significant reduction of CCT.

关键词： corneal edema after cataract surgery central corneal thickness lactate dehydrogenase trans-corneal oxygenation

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Differential pulse voltammetric studies on the effects of Al(Ⅲ) on the lactate dehydrogenase activity

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Chinese Chemical Letters 2007年第7期18卷 857-860页

作者： Kai An Yao Na Wang Jing Yue Zhuang Zheng Biao Yang Hai Yan Ni Quan Xu Cheng Sun Shu Ping Bi State Key Laboratory of Pollution Control and Resource Reuse ＆ Key Laboratory of MOE for Life Science School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China

In this paper, differential pulse voltammetry （DPV） was applied to study the effects of aluminum Al（Ⅲ） on the lactate dehydrogenase （LDH） activity. Michaelis-Menten constant （Km^NADH） and maximum velocity （vmax） in the enzyme promoting catalytic reaction of ＂pyruvate（Pyr）＋ NADH ＋ H^＋ ↑LDH←→lactate ＋ NAD^＋＂ under different conditions by monitoring DPV reduction current of NAD^＋ were reported.

关键词： Al（Ⅲ） DPV lactate dehydrogenase Biomarker

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Predictive value of serum lactate dehydrogenase in diagnosis of septic shock in critical pediatric patients:A cross-sectional study

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Journal of Acute Disease 2021年第3期10卷 107-111页

作者： HebatAllah Fadel Algebaly Ahmed Abd-Elal Rasha El Kaffas Elshymaa Salah Ahmed Pediatric Critical Care Department Cairo University School of MedicineEgypt Department of Clinical and Chemical Pathology Cairo University School of MedicineEgypt

Objectives:To determine the predictive value of lactate dehydrogenase(LDH)in the diagnosis of septic shock and its association with other prognostic scores in critical pediatric patients.Methods:A cross-sectional study was performed at Children’s Hospital of Cairo University between June 2019 and December 2019.A total of 200 pediatric patients were divided into the septic shock group[100 critically ill patients with septic shock from the pediatric intensive care unit(PICU)]and the control group(100 patients with only sepsis).LDH was determined in the first 24 hours of admission.The sensitivity and specificity of LDH in diagnosis of septic shock were assessed;the levels of related indicators of patients with different etiologies were compared;correlations between LDH,Paediatric Index of MortalityⅡ,and Pediatric Sequential Organ Failure Assessment(pSOFA)were analyzed.Results:Median LDH was 512μL(406.50-663.00)in the septic shock group and was significantly higher than that[190μL(160.00-264.50)]in the control group(P<0.001).Besides,median LDH in children with chest infecion was higher than that in children with other diagnoses(P=0.047).A good positive correlation was found between pSOFA and LDH(r=0.503,P<0.001).Conclusions:LDH could be a potential inflammatory marker in the diagnosis of septic shock and is valuable for PICU admission decisions.

关键词： lactate dehydrogenase Septic shock pSOFA

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Inactivation　and　Conformational　Changes　of　lactate　dehydrogenase　M4　during　Unfolding　in　Urea　Solutions

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Tsinghua Science and Technology 1997年第1期2卷 36-38页

作者：郭宇远周海梦

The conformational changes,followed by fluorescence emission and exposure of buried SH groups,and the inactivation of lactate dehydrogenase M 4 in urea solutions have been studied. The results show that inactivation occurs before noticeable conformational change can be detected.It can be suggested that the active sites of lactate dehydrogenase M 4 also display more conformational flexibility than the enzyme molecule as a whole.

关键词： lactate dehydrogenase inactivation unfolding

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