检索结果-南通市图书馆

A multichannel thermal bubble-actuated impedance flow cytometer with on-chip TIA based on CMOS-MEMS

Journal of Semiconductors 2024年第5期45卷 41-49页

作者： Shengxun Cai Jianqing Nie Kun Wang Yimin Guan Demeng Liu School of Microelectronics Shanghai UniversityShanghai 201800China Shanghai AURE Technology Limited Company Shanghai 201800China

Electrochemical impedance spectroscopy(EIS)flow cytometry offers the advantages of speed,affordability,and portability in cell analysis and cytometry ***,the integration challenges of microfluidic and EIS read-out circuits hinder the downsizing of cytometry *** address this,we developed a thermal-bubble-driven impedance flow cytometric application-specific integrated circuit(ASIC).The thermal-bubble micropump avoids external piping and equipment,enabling high-throughput *** a total of 36 cell counting channels,each measuring 884×220μm^(2),the chip significantly enhances the throughput of flow *** cell counting channel incorporates a differential trans-impedance amplifier(TIA)to amplify weak biosensing *** eliminating the parasitic parameters created at the complementary metal-oxidesemiconductor transistor(CMOS)-micro-electromechanical systems(MEMS)interface,the counting accuracy can be *** on-chip TIA can adjust feedback resistance from 5 to 60 kΩto accommodate solutions with different *** chip effectively classifies particles of varying sizes,demonstrated by the average peak voltages of 0.0529 and 0.4510 mV for 7 and 14μm polystyrene beads,***,the counting accuracies of the chip for polystyrene beads and MSTO-211H cells are both greater than 97.6%.The chip exhibits potential for impedance flow cytometer at low cost,high-throughput,and miniaturization for the application of point-of-care diagnostics.

关键词： EIS flow cytometry CMOS-MEMS thermal bubble lab-on-chip

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On-chip classification of micro-particles using laser light scattering and machine learning

引用

Chinese Chemical Letters 2022年第4期33卷 1885-1888页

作者： Mubashir Hussain Xiaolong Liu Jun Zou Jian Yang Zeeshan Ali Hamood Ur Rehman Nongyue He Jianguo Dai Yongjun Tang Innovation Practice Shenzhen PolytechnicShenzhen 518055China School of Materials and Chemical Engineering Hunan Institute of EngineeringXiangtan 411104China Department of Electrical Engineering College of EMENational University of Sciences and TechnologyH-12 IslamabadPakistan State Key laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

The rapid detection of microparticles exhibits a broad range of applications in the field of science and technology. The proposed method differentiates and identifies the 2 μm and 5 μm sized particles using a laser light scattering. The detection method is based on measuring forward light scattering from the particles and then classifying the acquired data using support vector machines. The device is composed of a microfluidic chip linked with photosensors and a laser device using optical fiber. Connecting the photosensors and laser device using optical fibers makes the device more diminutive in size and portable. The prepared sample containing microspheres was passed through the channel, and the surrounding photosensors measured the scattered light. The time-domain features were evaluated from the acquired scattered light, and then the SVM classifier was trained to distinguish the particle’s data. The real-time detection of the particles was performed with an overall classification accuracy of 96.06%. The optimum conditions were evaluated to detect the particles with a minimum concentration of 0.2 μg/m L. The developed system is anticipated to be helpful in developing rapid testing devices for detecting pathogens ranging between 2 μm to 10 μm.

关键词： Particle’s detection Laser light scattering Waveform features Support vector machines lab-on-chip

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A NOVEL TECHNIQUE FOR MULTIPLE FAULTS AND THEIR LOCATIONS DETECTION AND START ELECTRODE SELECTION IN MICROFLUIDIC DIGITAL BIOchip

引用

Journal of Innovative Optical Health Sciences 2013年第4期6卷 19-26页

作者： MUKTA MAJUMDER NILANJANA DAS SUJAN KUMAR SAHA Department of Computer Science and Engineering Birla Institute of Technology Mesra RanchiJharkhandIndia Maynaguri CCC WBSEDCLJalpaiguri West BengalIndia

A device,that is used for biomedical operation or safety-critical applications like point-of-care health asssment,massive parallel DNA analysis,automated drug discovery,air-quality monitoring and food-safety testing,must have the attributes like relia bility,dependability and *** the biochips are used for these purposes;therefore,these devices must be fault free all the *** before usi ng these chips,they must be well *** are proposing a novel technique that can detect mutiple fults,locate the fault positions within the biochip,as well as calculate the traversal time if the biochip is fault *** proposed technique also highlights a new idea how to select the appropriate base node or pseudo source(start electrode).The main idea of the proposed technique is to form multiple loops with the neighboring electrode arrays and then test each loop by traversing test droplet to check whether there is any *** a fault is detected then the propoed technique also locates it by backtracking the test *** case,no fault is detected,the biochip is fault free then the proposed technique also calculates the time to traverse the *** result suggests that the proposed technique is eficient and shows significant improvement to ca lculate fault-free biochip traversal time over existing method.

关键词： Biochip lab-on-chip medical microsystems biochemical droplet biomedical operation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microfluidic chip enables single-cell measurement for multidrug resistance in triple-negative breast cancer cells

引用

Cancer Drug Resistance 2020年第3期3卷 613-622页

作者： Karan Parekh Hamideh Sharifi Noghabi Jose Alejandro Lopez Paul Chi Hang Li Department of Molecular Biology&Biochemistry Simon Fraser UniversityBurnaby V5A 1S6Canada. Department of Chemistry Simon Fraser UniversityBurnaby V5A 1S6Canada. School of Environment&Science Griffith UniversityNathanQueensland 4111Australia.

Aims:Triple-negative breast cancer patients are commonly treated with combination ***,outcomes remain substandard with relapses being of a frequent *** the several mechanisms that result in treatment failure,multidrug resistance,which is mediated by ATP-binding cassette proteins,is the most *** of the substantial studies conducted on the heterogeneity of cancer types,only a few assays can distinguish the variability in multidrug resistance activity between individual *** aim to develop a single-cell assay to study ***:This experiment utilized a microfluidic chip to measure the drug accumulation in single breast cancer cells in order to understand the inhibition of drug efflux ***:Selection of single cells,loading of drugs,and fluorescence measurement for intracellular drug accumulation were all conducted on a microfluidic *** a result,measurements of the accumulation of chemotherapeutic drugs(e.g.,daunorubicin and paclitaxel)in single cells in the presence and absence of cyclosporine A were *** such as initial drug accumulation,signal saturation time,and fold-increase of drug with and without the presence cyclosporine A were also ***:The results display that drug accumulation in a single-cell greatly enhanced over its same-cell control because of inhibition by cyclosporine ***,this experiment may provide a platform for future liquid biopsy studies to characterize the multidrug resistance activity at a single-cell level.

关键词： MDA-MB-231 cell triple-negative breast cancer microfluidic chip lab-on-chip multidrug resistance single-cell analysis fluorescence measurement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

微纳流体光波导及其在生物传感器中的应用

引用

光学精密工程 2013年第4期21卷 987-999页

作者：黎永前 ﹡ 苏磊满力寿宸叶芳徐征西北工业大学空天微纳系统教育部重点实验室陕西西安710072 大连理工大学辽宁省微纳米技术及系统重点实验室辽宁大连116023

微纳流体光波导融合了微观流体与微光学特征,能够在相同物理空间实现流体介质和微光学信息功能及结构的集成,是生物化学分析及生物传感器的关键器件。本文综述了微纳流体光波导研究现状及其在生物传感器和生物化学分析中的应用实例。论... 详细信息

微纳流体光波导融合了微观流体与微光学特征,能够在相同物理空间实现流体介质和微光学信息功能及结构的集成,是生物化学分析及生物传感器的关键器件。本文综述了微纳流体光波导研究现状及其在生物传感器和生物化学分析中的应用实例。论述了实现微纳流体光波导的全反射机理、多层干涉效应,抗谐振反射机理,以及基于上述机理实现的各种流体波导形式。重点分析了基于微纳流体层流效应的全流体波导,基于多层干涉效应的Bragg光波导、空心光子晶体波导、狭缝光流体波导、抗谐振反射光波导等多种波导的特点。指出狭缝光流体波导和抗谐振反射光波导具有更好的设计灵活性,且检测灵敏度高、可靠性好、易于集成制造,可望在生物传感器及微纳流体光学系统中得到更广泛的应用。

关键词：微纳流体光波导流体芯层液体覆层微流体沟道折射率系数 lab-on-chip 热流体集成光流体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：