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3D printed microfluidic devices:a review focused on four fundamental manufacturing approaches and implications on the field of healthcare

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Bio-Design and Manufacturing 2021年第2期4卷 311-343页

作者： Viraj Mehta Subha N.Rath Regenerative Medicine and Stem Cells laboratory Department of Biomedical EngineeringIndian Institute of Technology HyderabadKandiTelangana 502285India

In the last fewyears,3D printing has emerged as a promising alternative for the fabrication ofmicrofluidic devices,overcoming some of the limitations associated with conventional ***(SLA),extrusion-based technology,and inkjet 3D printing are three of the widely used 3D printing technologies owing to their accessibility and *** devices can be 3D printed by employing a manufacturing approach from four fundamental manufacturing approaches classified as(1)direct printing approach,(2)mold-based approach,(3)modular approach,and(4)hybrid *** evaluate the feasibility of 3D printing technologies for fabricating microfluidic devices,a review focused on 3D printing fundamental manufacturing approaches has been *** a broad spectrum of additive manufacturing materials,3D printed microfluidic devices have been implemented in various fields,including biological,chemical,and material ***,some crucial challenges are associated with the same,including low resolution,low optical transparency,cytotoxicity,high surface roughness,autofluorescence,non-compatibility with conventional sterilization methods,and low gas *** recent research progress in materials related to additive manufacturing has aided in overcoming some of these ***,we outline possible implications of 3D printed microfluidics on the various fields of healthcare such as in vitro disease modeling and organ modeling,novel drug development,personalized treatment for cancer,and cancer drug screening by discussing the current state and future outlook of 3D printed‘organs-on-chips,’and 3D printed‘tumor-on-chips.’We conclude the review by highlighting future research directions in this field.

关键词： 3D printing Additive manufacturing Microfluidics lab-on-a-chip Organ-on-a-chip Tumor-on-a-chip

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Photoic crystal nanobeam cavity devices for on-chip integrated silicon photonics

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Journal of Semiconductors 2021年第2期42卷 40-50页

作者： Daquan Yang Xiao Liu Xiaogang Li Bing Duan Aiqiang Wang Yunfeng Xiao State Key laboratory of Information Photonics and Optical Communications and School of Information and Communication EngineeringBeijing University of Posts and TelecommunicationsBeijing 100876China State Key laboratory for Artificial Microstructure and Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China Frontiers Science Center for Nano-Optoelectronics&Collaborative Innovation Center of Quantum Matter Beijing 100871China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Beijing Academy of Quantum Information Sciences Beijing 100193China

Integrated circuit(IC)industry has fully considered the fact that the Moore’s Law is slowing down or *** solutions are highly and urgently desired to break the physical size limits in the More-than-Moore *** silicon photonics technology exhibits distinguished potential to achieve faster operation speed,less power dissipation,and lower cost in IC industry,because their COMS compatibility,fast response,and high monolithic integration ***,compared with other on-chip resonators(***,2D photonic crystal cavities)silicon-on-insulator(SOI)-based photonic crystal nanobeam cavity(PCNC)has emerged as a promising platform for on-chip integration,due to their attractive properties of ultra-high Q/V,ultra-compact footprints and convenient integration with silicon *** this paper,we present a comprehensive review on recent progress of on-chip PCNC devices for lasing,modulation,switching/filting and label-free sensing,etc.

关键词： PCNC integrated silicon photonics More-than-Moore lab-on-a-chip hybrid devices

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DETECTION AND APPLICATION OF MICROFLUIDIC ISOTHERMAL AMPLIFICATION ON chip

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Journal of Innovative Optical Health Sciences 2008年第2期1卷 257-265页

作者： GUOLIANG HUANG XIAOYONG YANG JIANG ZHU SHUKUAN XU CHENG DENG CHAO HAN Medical Systems Biology Research Center Tsinghua University School of Medicine Beijing 100084China National Engineering Research Center for Beijing Biochip Technology Beijing 102206China

Loop-mediated isothermal amplification(LAMP)is a novel nucleic acid amplification *** with the widely utilized polymerase chain reaction(PCR),LAMP has higher speed and efficiency as well as lower requirement for system temperature control because the whole amplification process is isothermal and no efforts are needed to switch between different *** this paper,we designed and fabricated different kinds of polycarbonate(PC)microfluid chips,explored appropriate reaction condition for LAMP in microenvironment(1 nL→10μL),and developed a microfluidic isothermal amplification detection *** DNA optimal amplification temperature is obtained;the starting time of exponential amplification of DNA is put forward *** optimal condition of DNA amplification in microenvironment,with a little reaction materials and early starting exponential amplification time of DNA are very important for clinic DNA detection and the application of lab-on-a-chip.

关键词： Loop-mediated isothermal amplification lab-on-a-chip microfluid chips polymerase chain reaction DNA amplification

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Progress of Microfluidics for Biology and Medicine

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Nano-Micro Letters 2013年第1期5卷 66-80页

作者： Jingdong Chen Di Chen Yao Xie Tao Yuan Xiang Chen Science and Technology on Micro/Nano Fabrication laboratory Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong University Key laboratory for Thin Film and Microfabrication of the Ministry of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong University

Microfluidics has been considered as a potential technology to miniaturize the conventional equipments and technologies. It offers advantages in terms of small volume, low cost, short reaction time and highthroughput. The applications in biology and medicine research and related areas are almost the most extensive and profound. With the appropriate scale that matches the scales of cells, microfluidics is well positioned to contribute significantly to cell biology. Cell culture, fusion and apoptosis were successfully performed in microfluidics. Microfluidics provides unique opportunities for rare circulating tumor cells isolation and detection from the blood of patients, which furthers the discovery of cancer stem cell biomarkers and expands the understanding of the biology of metastasis. Nucleic acid amplification in microfluidics has extended to single-molecule, high-throughput and integration treatment in one chip. DNA computer which is based on the computational model of DNA biochemical reaction will come into practice from concept in the future. In addition, microfluidics offers a versatile platform for protein-protein interactions, protein crystallization and high-throughput screening. Although microfluidics is still in its infancy, its great potential has already been demonstrated and will provide novel solutions to the high-throughput applications.

关键词： Microfluidics lab-on-a-chip Droplet High-throughput Cell Nucleic acid amplification

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Assessing phylogenetic relationships of Lycium samples using RAPD and entropy theory

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Acta Pharmacologica Sinica 2005年第10期26卷 1217-1224页

作者： Ricky NS WONG Amber WY HA Department of Biology Hong Kong Baptist University Hong Kong China Department of Biology Hong Kong Baptist University Hong Kong China

Aim: To evaluate the phylogenetic relationships among related species of Lycium samples. Methods: Random amplified polymorphic DNA (RAPD) fingerprinting and lab-on-a-chip electrophoresis techniques were used to analyze the characteristics of Lycium species. Seven species and 3 varieties of Lycium were studied. Based on RAPD fingerprint data obtained from 11 primers, we proposed a new index, called dispersivity, using entropy theory and projection methods to depict the diversity of the DNA fingerprints. Results: Using the proposed dispersivity, primers were sorted and the dendrograms of the 7 species and 3 varieties of Lycium were constructed synthetically by merging primer information. Conclusion:Phylogenetic relationships among Lycium samples were constructed synthetically based on RAPD fingerprint data generated from 11 primers.

关键词： DNA fingerprinting RAPD technique lab-on-a-chip entropy UPGMA

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Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing

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Light(Science & Applications) 2017年第1期6卷 585-592页

作者： Srdjan S Aćimović Hana Šípová Gustav Emilsson Andreas B Dahlin Tomasz J Antosiewicz Mikael Käll Department of Physics Chalmers University of Technology41296 GöteborgSweden Department of Chemistry and Chemical Engineering Chalmers University of Technology41296 GöteborgSweden Centre of New Technologies University of WarsawBanacha 2c02-097 WarsawPoland

Localized surface plasmon resonance(LSPR)biosensing based on supported metal nanoparticles offers unparalleled possibilities for high-end miniaturization,multiplexing and high-throughput label-free molecular interaction analysis in real time when integrated within an opto-fluidic ***,such LSPR-sensing devices typically contain extremely large regions of dielectric materials that are open to molecular adsorption,which must be carefully blocked to avoid compromising the device *** address this issue,we made the support essentially invisible to the LSPR by carefully removing the dielectric material overlapping with the localized plasmonic fields through optimized *** resulting LSPR substrate,which consists of gold nanodisks centered on narrow SiO2 pillars,exhibits markedly reduced vulnerability to nonspecific substrate adsorption,thus allowing,in an ideal case,the implementation of thicker and more efficient passivation *** demonstrate that this approach is effective and fully compatible with state-of-the-art multiplexed real-time biosensing technology and thus represents the ideal substrate design for high-throughput label-free biosensing systems with minimal sample consumption.

关键词： biosensing hyperspectral lab-on-a-chip LSPR nonspecific adsorption

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chip-scale gas chromatography:From injection through detection

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Microsystems & Nanoengineering 2015年第1期1卷 8-15页

作者： Muhammad Akbar Michael Restaino Masoud Agah VT MEMS laboratory Bradley Department of Electrical and Computer EngineeringVirginia TechBlacksburgVA 24061USA Department of Biomedical Engineering and Mechanics Virginia TechBlacksburgVA 24061USA

Miniaturized gas chromatography(μGC)systems hold potential for the rapid analysis of volatile organic compounds(VOCs)in an extremely compact and low-power enabled ***,we utilize microfabrication technology to demonstrate the single chip integration of the key components of aμGC system in a two-step planar fabrication *** 1.5×3 cm microfluidic platform includes a sample injection unit,a micromachined semi-packed separation column(μSC)and a micro-helium discharge photoionization detector(μDPID).The sample injection unit consists of a T-shaped channel operated with an equally simple setup involving a single three-way fluidic valve,a micropump for sample loading and a carrier gas supply for subsequent analysis of the *** innovative sample injection technique described herein requires a loading time of only a few seconds and produces sharp and repeatable sample pulses(full width at half maximum of approximately 200 ms)at a carrier gas flow rate that is compatible with efficient chromatographic ***,our comprehensive characterization of the chip reveals that a wide variety of VOCs with boiling points in the range of 110–216℃ can be analyzed in less than 1 min by optimizing the flow and temperature programming ***,the analysis of four VOCs at the concentration level of one part per million in an aqueous sample(which corresponds to a headspace concentration in the lower parts-per-billion regime)was performed with a sampling time of only 6 *** μDPID has demonstrated a linear dynamic range over three orders of *** system presented here could potentially be used to monitor hazardous VOCs in real time in industrial workplaces and residential settings.

关键词： gas chromatography lab-on-a-chip MEMS microsystem

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Microfluidics:Emerging prospects for anti-cancer drug screening

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World Journal of Clinical Oncology 2010年第1期1卷 18-23页

作者： Donald Wlodkowic Zbigniew Darzynkiewicz Auckland Microfabrication Facility Department of ChemistryUniversity of Auckland1142 AucklandNew Zealand Brander Cancer Research Institute Department of PathologyNew York Medical CollegeValhallaNY 10595United States

Cancer constitutes a heterogenic cellular system with a high level of spatio-temporal *** discoveries by systems biologists have provided emerging evidence that cellular responses to anti-cancer modalities are stochastic in *** uncover the intricacies of cell-to-cell variability and its relevance to cancer therapy,new analytical screening technologies are *** last decade has brought forth spectacular innovations in the field of cytometry and single cell cytomics,opening new avenues for systems oncology and high-throughput real-time drug screening *** up-and-coming microfluidic lab-on-a-chip(LOC)technology and micrototal analysis systems(μTAS)are arguably the most promising platforms to address the inherent complexity of cellular systems with massive experimental parallelization and 4D analysis on a single cell *** vast miniaturization of LOC systems and multiplexing enables innovative strategies to reduce drug screening expenditures while increasing throughput and content of information from a given *** cell numbers and operational reagent volumes are sufficient for microfluidic analyzers and,as such,they enable next generation high-throughput and high-content screening of anticancer drugs on patient-derived *** we highlight the selected advancements in this emerging field of bioengineering,and provide a snapshot of developments with relevance to anti-cancer drug screening routines.

关键词： Microfluidics lab-on-a-chip Cytometry Cytomics Cancer Anti-cancer drugs Cancer therapy Drug screening

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生物芯片──二十一世纪革命性的技术

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基础医学与临床 2000年第4期20卷 1-4页

作者：谢文章卢英邢婉丽程京清华大学生物芯片研究与开发中心北京100084

Biochip is a kind of minimized and integrated analyzer for molecular biology and biochemistry. Advances in biochip technology enable massive parallel mining of biological data, with biochips providing hybridizationbased expression monitoring, polymorphism detection and genotyping on a genomic scale. Microarrays may soon permit the expression analysis of the entire human genome in a single reaction. These ’genome chips’ will provide access to key areas of human health, including disease diagnosis, drug discovery, toxicology, etc. Microarray technology is rapidly becoming a central platform for functional genomics. Development of biochips is to immigrate the eatire analysis process of biochemical reactions and establish the micro total analytical system or lab-on-a-chip.

关键词：生物芯片基因表达 DNA lab-on-a-chip

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自动芯片实验室平台

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生物技术世界 2005年第8M期2卷 91-91页

Agilent公司的5100 Automated lab-on-a-chip Platform，一个完全自动的电泳工作流操作，每个流程允许无人值守分析多达3，840DNA和蛋白样本。使用样本和试剂的量最小，减少有害废物和每个样本的费用。基于它的自动和内部访问标准，5100... 详细信息

Agilent公司的5100 Automated lab-on-a-chip Platform，一个完全自动的电泳工作流操作，每个流程允许无人值守分析多达3，840DNA和蛋白样本。使用样本和试剂的量最小，减少有害废物和每个样本的费用。基于它的自动和内部访问标准，5100Automated lab-on-a-chip Platform提供重现性的，可比较的数据。

关键词：全自动 lab-on-a-chip 芯片实验室 Agilent公司平台 5100 无人值守有害废物工作流

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