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lxhy formula Inhibits Choroidal Neovascularization Development via Inhibiting the Recruitment and Adhesion of BMCs to the Retina

引用

World Journal of Traditional Chinese Medicine 2018年第2期4卷 62-68页

作者： Li-Na Liang You-Zhi Tang Wen-Jie Zhan Jiao Li Qun-Ying Ma Jie Liang Department of Ophthalmology Research Laboratory Eye HospitalChina Academy of Chinese Medical Sciences

Objective:The objective of this study is to investigate the inhibitory effect of lxhy,a Chinese medicine compound formula,on choroidal neovascularization(CNV) and to find the possible working ***:CNV was induced in C57 BL/6 mice by krypton laser and bone marrow-derived cells(BMCs) isolated from enhanced green fluorescent protein(EGFP) transgenic mice were injected through tail vein 0.5–1 h after the laser *** BMC-treated mice were randomly divided into two groups gavaged with either distilled water(DW group) or lxhy formula solution from day 1 after laser *** days 7,14,and 28 after treatment,histopathologic examination,fundus fluorescein angiography,and choroidal flatmount assay were performed to measure the CNV severity and BMC ***4 levels in peripheral blood were measured by enzyme-linked immunosorbent *** cell-derived factor-1α(SDF?1α),vascular cell adhesion molecule-1(VCAM-1),and intercellular adhesion molecule-1(ICAM-1) were detected by immunofluorescent ***:On days 7 and 14 after treatment,CNV lesions in the lxhy-treated mice showed less recruitment of BMCs and were smaller in size compared to DW-treated *** examination also confirmed less severe CNV lesions in the lxhy ***4 levels in peripheral blood in the lxhy group were less than that of DW group on days 7 and ***,the expression levels of SDF-1α,ICAM?1,and VCAM?1 at the lesion sites in the lxhy group were lower compared with the DW ***:This experiment indicated that lxhy formula could inhibit CNV formation and development,probably by inhibiting the recruitment and attachment of BMCs into CNV area.

关键词： Age-related macular degeneration bone marrow-derived cells choroidal neovascularization lxhy formula

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