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INCREASED VULNERABILITY OF HYPERTROPHIED MYOCARDIUM TO ISCHEMIA AND REPERFUSION INJURY RELATION TO CARDIAC RENIN-ANGIOTENSIN SYSTEM

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Chinese Medical Journal 1995年第1期108卷 28-32页

作者：章友华徐守春 Cardiovascular Institute & Fuwai Hospital Chinese Academy of Medical Sciences Beijing 100037 Department of Anesthesia and Fuwai Hospital Beijing

Hearts of pressure-overload hypertrophy show an increased activation of intracardiac renin-angiotensin system which may contribute to ischemia and reperfusion injury. The purpose of this study is to evaluate whether the hypertrophied myocardium is more vulnerable to ischemia and reperfusion injury and to find out its relation to the cardiac renin-angiotensin system. Hypertrophied rat hearts induced by abdominal aortic banding for 6 weeks were subjected to 2 hours of hypothermic ischemic arrest followed by 30 minutes of reperfusion, and their cardiac function recovery was compared with that of sham-operated normal control hearts. The cardiac renin activity and angiotensin II content before ischemia and after reperfusion were determined. It was found that both the pre-ischemic renin activity and angiotensin II level were higher in hypertrophied myocardium than those in the control: ischemia and reperfusion injury increased both renin activity and angiotensin II content in the two groups, but the renin activity and angiotensin II level were further elevated after reperfusion in the hypertrophied hearts than those in the control hearts. Meanwhile, the cardiac function recovery after 30 minutes reperfusion in the hypertrophied hearts was poorer than that in the control. Correlation analysis revealed that there was a negative correlation between the cardiac output recovery and the myocardial angiotensin II content (r=-0.841), P<0.001), It is concluded that ischemia and reperfusion injury can activate cardiac renin-angiotensin system in isolated rat heart, which may be responsible for the increased susceptibility of the hypertrophied myocardium to ischemia and reperfusion injury.

关键词： lvedp INCREASED VULNERABILITY OF HYPERTROPHIED MYOCARDIUM TO ISCHEMIA AND REPERFUSION INJURY RELATION TO CARDIAC RENIN-ANGIOTENSIN SYSTEM LVSP In mode than

Cytokines expression and ventricular remodeling and intervention with different doses of carvedilol following rat coronary microembolization

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上海医学 2007年第S1期30卷 197-198页

作者： WANG Wei-wei, CHEN Liang-long. Cardiology, Union Hospital of Fujian Medical University & Fujian Provincial Institute of Coronary Disease, Fuzhou 350001, China

Objectives To explore changes of myocardial pro-inflammatory and fibrogenic cytokines after coronary microembolization (CME) in rats. To observe effects of carvedilol at different doses on myocardial cytokines expression and ventricular remodeling. Methods A rat model of CME was created by injecting a suspension of microthrombotic particles generated from rat clots into left ventricle when clamping the ascending aorta. Forty SD rats were randomly divided into 4 groups(n=10 per group): sham-operation group(SO), CME group(ME), low-dose carvedilol intervention group (LCAR,1.0 mg·kg-1·d-1) and high-dose carvedilol intervention group (HCAR, 10.0 mg·kg-1·d-1). A microscopy incorporated with an image analysis software was employed to calculate the number of micro-myocardial infarction (Nmmi) and the area of micro-myocardial infarction (Ammi) in sections with HE-staining, to measure the collagen volume fraction(CVF) in sections with Sirius-Red-staining, to detect the density of expressions of TNF-α, IL-1β, TGF-β1 and MMP-9 in sections with immunohistchemical staining, to calculate the myocyte apoptosis rate (Rapo) in sections with TUNEL-staining. Two-dimensional Echocardiography was performed to monitor left ventricular end-diastolic diameter (LVEDD) and end-systolic diameter (LVESD), left ventricular fraction shortening (LVFS) and ejection fraction (LVEF); and electrophysiolography was utilized to measure left ventricular systolic pressure(LVSP), maximal positive dp/dt (+ LVdp/dtmax), and end diastolic pressure(lvedp). Four weeks after operation, comparing measurements in ME with those in SO, both Nmmi and Ammi were increased(Plvedp was increased (P<0.01). Comparing with

关键词： remodeling LVESD LVEDD myocyte interstitial ejection lvedp diastolic sections staining

Effect of ETA receptor antagonist BQ-123 on cardiac function and endothelin system after coronary microembolization in rats

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上海医学 2007年第S1期30卷 196-197页

作者： LIN Yun-ling CHEN Liang-long Cardiology, Union Hospital of Fujian Medical University & Fujian Provincial Institute of Coronary Disease, Fuzhou 350001, China

Objective To evaluate the effects of BQ-123 on cardiac function and ventricular remodelling after coronary microembolization (CME) in rats. Methods We created a rat model of CME by injecting a suspension of autogenic microthrombotic particles into left ventricle. Three days after the procedure, the 30 surviving rats were randomly divided into 3 groups, each consisted of 10 rats: sham-operation group(SO), CME model group(CM) and BQ-123 intervention group(BQ). Rats in the BQ group received BQ-123 (400μg/kg per day, intraperitoneally) for 4 weeks. Plasma and myocardial endothelin-1 (ET-1) were measured by radioimmunoassay. And serial echocardiography was performed to monitor alterations of left ventricular end-systolic and end-diastolic diameter (LVESD, LVEED), and left ventricular short-axis fraction shortening(LVFS) and ejection fraction (LVEF), and physiologicography to document the changes of left ventricular systolic pressure (LVSP) and end-diastolic pressure pressure(lvedp), and left ventricular maximum positive and negative dp/dt (±LVdp/dtmax). Results Compared with sham-operated group, both LVEDD and LVESD were increased (Plvedp was markedly increased, while LVSP and±LVdp/ dtmax markedly reduced in CME group (P<0.01); plasma and tissue ET-1 levels increased in CME group (P<0.01). BQ-123 intervention significantly decreased both the plasma and tissue ET-1 levels (P<0.01), and markedly increased LVFS and LVEF, with significant improvement of LVSP and±LVdp/ dtmax (P<0.01). Conclusions Treatment with BQ-123 prevents ventricular remodeling after CME due to suppression of the endothelin system.

关键词： endothelin LVESD ejection markedly remodeling diastolic lvedp LVEDD systolic antagonist

EFFECT OF ELECTROACUPUNCTURE ON CARDIAC PUMPING FUNCTION OF CANINE WITH EXPERIMENTAL ANGINA PECTORIS

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针刺研究 1989年第Z1期 191-192页

作者： Wu Peilin Meng Jingbi Fu Weixing Song Liming Institute of Acupuncture and Moxibustion, China Academy of Traditional Chinese Medicine Department of Physiology Hangzhou Branch of Zhejiang Medical University

This experiment was performed on 35 dogs anesthetized with pentobarbitalsodiom in abdominal cavity. These dogs were intabated and maintained respi-ration. The heart was exposed through a left lateral throacotomy, throughperistatic pump, blood in carotis was transported to left anterior descendingcoronary (LAD), experimental myocardial ischemia modal was set up epicardiumelcctrocardiogram of 12 points left ventricular pressure(LVP) and mean arterialpressure (MAP) were recerded with 8-channel polygraph. Cardiac output wastecorded with MF-27 electromegnetic blood flowmeter. The experimental

关键词： lvedp Cl CO LVP EFFECT OF ELECTROACUPUNCTURE ON CARDIAC PUMPING FUNCTION OF CANINE WITH EXPERIMENTAL ANGINA PECTORIS

中药通心络对猪急性心肌梗死再灌注后无再流的影响

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中华医学杂志 2005年第13期85卷 883-888页

作者：杨跃进赵京林荆志成吴永健尤士杰杨伟宪孟亮田毅陈纪林高润霖陈在嘉中国医学科学院中国协和医科大学阜外心血管病医院冠心病诊疗中心北京100037

目的评价通心络防治猪急性心肌梗死(AMI)再灌注后无再流的作用。方法中华小型猪40只随机分成5组,每组8只:(1)AMI模型对照组(对照组),(2)通心络小剂量治疗组(0·05g·kg-1·d-1),(3)通心络中剂量治疗组(0·2g·kg-1·d-1),(4)通心络大剂... 详细信息

目的评价通心络防治猪急性心肌梗死(AMI)再灌注后无再流的作用。方法中华小型猪40只随机分成5组,每组8只:(1)AMI模型对照组(对照组),(2)通心络小剂量治疗组(0·05g·kg-1·d-1),(3)通心络中剂量治疗组(0·2g·kg-1·d-1),(4)通心络大剂量治疗组(0·5g·kg-1·d-1),(5)假手术组。通心络各组预给药3d后行冠状动脉结扎180min,松解60min制备AMI再灌注模型。AMI前、后和再灌注后均行血流动力学测定,心肌声学造影(MCE)检查和病理学分析。结果(1)与AMI前相比,对照组AMI后180min左室收缩压(LVSP)、心排量和左心室内压最大收缩和舒张变化速率(±dp/dtmax)均显著下降(Plvedp)显著升高(Plvedp、±dp/dtmax和心排量均显著恢复(均P0·05),再灌注后无再流区范围分别为78·5%和82·3%,心肌坏死面积占结扎区心肌面积的98·5%。3个通心络组LA与对照组相当(均P>0·05),但MCE和病理染色所测无再流范围在中及大剂量通心络组分别为41·1%、42·4%和24·1%、25·0%,坏死心肌范围分别为90·2%及81·2%,均显著小于对照组和小剂量组(P<0·05或P<0·01),大剂量组也显著小于中剂量组(P<0·05或P<0·01)。(3)对照组再灌注后即刻和再灌注后60min冠脉血流量仅占AMI前的45·8%和50·6%(均P<0·01),而大剂量通心络组冠脉血流量分别占AMI前的76·0%和73·5%,均显著高于对照组(均P<0·01)。结论通心络能有效地防治心肌梗死再灌注后无再流,缩小梗死面积;中剂量有效,大剂量更好。

关键词：通心络无再流急性心肌梗死(AMI) 冠脉血流量中药冠状动脉结扎心肌声学造影 0.05 左室舒张末压心肌坏死面积对照组大剂量再灌注模型动力学测定病理学分析左心室内压 lvedp 治疗组中剂量 LVSP 指标变化冠脉结扎

线粒体ATP敏感性钾通道不参与异丙酚预处理的心肌保护

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中国药理学通报 2003年第10期19卷 1155-1159页

作者：王翠梅曹红戴体俊曾因明徐州医学院江苏省麻醉学重点实验室徐州221002

目的　观察异丙酚预处理对心肌缺血再灌注损伤的保护机制是否通过开放线粒体ATP敏感性K通道 (KATP)。方法　非循环式Langendorff离体心脏灌注模型 ,灌注 1h ,常温下行全心缺血 2 5min ,恢复再灌注 30min。通过Maclab仪记录左室舒张末压 ... 详细信息

目的　观察异丙酚预处理对心肌缺血再灌注损伤的保护机制是否通过开放线粒体ATP敏感性K通道 (KATP)。方法　非循环式Langendorff离体心脏灌注模型 ,灌注 1h ,常温下行全心缺血 2 5min ,恢复再灌注 30min。通过Maclab仪记录左室舒张末压 (lvedp)、左室发展压 (LVDP)、左室压上升和下降最大速率 (±dp/dtmax)。测恢复再灌注末心肌组织MDA含量。结果　恢复再灌注 30min末 ,对照组(Con)、异丙酚预处理组 (PP)、5 HD +PP和 5 HD组心肌组织的MDA含量分别为 (113 7± 2 0 9)、(89 4± 13 7)、(91 9± 14 4 )和 (114 8± 19 7)nmol·10 0mg-1。PP组和 5 HD+PP组的心肌MDA含量都明显低于Con组和 5 HD组 (P0 0 5 )。恢复再灌注 30min末 ,Con组、PP组、5 HD+PP组和 5 HD组的lvedp值分别为基础值的 5 1、3 2、3 6和 5 3倍。PP组和 5 HD +PP组lvedp值的上升幅度均明显低于Con组和 5 HD组 (P 0 0 5 )。结论　异丙酚预处理的心肌保护不是通过开放线粒体ATP敏感性K通道。

关键词：异丙酚预处理心肌缺血再灌注损伤 KATP MDA lvedp

CARDIOVASCULAR SYSTEM

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China Medical Abstracts(Internal Medicine) 2000年第2期17卷 86-92页

EFFECT OF SHENG MAI SAN ON LEFT VENTRICULAR PERFORMANCE IN CORONARY HEART DISEASE

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Journal of Traditional Chinese Medicine 1982年第1期2卷 57-62页

作者：廖家桢武泽民康廷培史载祥郭鲁之赵悦如王宗安郝青春 Department of Research on Qi and Blood Dongzhimen Hospital Affiliated to the Beijing College of Traditional Chinese Medicine

The present study aims at ascertaining thenature of Xin Qi Xu (XQX,deficiency of Heart-Qi) and the effect of the drug Sheng Mai San 生脉散(SMS) on heart performance,using systolicand diastolic time intervals as criteria in CHDassociated with XQX *** results ascompared with normal subjects showed increa-ses in QA2,PEP,ICT,IRP,SFP,RFP,a/H%,PEP/LVET and SFP/RFP and a reduction ofLVET,suggesting that the patients have a la-tent cardiac insufficiency possibly relating tothe nature of *** changes in systolic anddiastolic time intervals after intravenous ShengMai San were prolongation of MST and LVET,shortening of PEP and PEP/LVET,and slowingof heart *** changes are statisticallysignificant (P<0.05-0.001).The blood pressurewas not significantly *** changesand their degree suggest a positive inotropic ac-tion on myocardium and a reduction of myo-cardial oxygen consumption by Sheng Mat *** effects compared with Cedilanid-D showedthat the action of both drugs on systolic anddiastolic time intervals was *** ten-tatively suggest,therefore,that the inotropicaction of SMS simulates that of digitalis *** studies are needed to determinewhether SMS affects the heart in the same wayas digitalis glycosides,for current work indica-tes that SMS may have other effects on theheart.

关键词： LVET lvedp RFP SMS ICT PEP

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Lung function

外科研究与新技术 1993年第2期 89-90页

930287 The investigation of the correlationsbetween lvedp and pulmonary function *** Tianqiao (姚天樵),et *** Hosp,Beijing,*** J Tuberc &Respir dis 1993;16(1):18—*** ventricular end diastolic pressure(lvedp)in 24 patients with coronary,hyper-tension or rheumatic heart disease (mainly aor-tic valve pathologic change,exclude mitralstenosis),had unobvious clinical heart *** left heart catheterization

关键词： lvedp Lung function ACE