检索结果-南通市图书馆

World Journal of AIDS 2017年第3期7卷 223-229页

作者： Majesté Ihou Wateba Komi Adjoh Lidawou Bawe Awerewou Kotosso A. Patassi Abago Balaka Infectious and Tropical Diseases Service of CHU SO Lomé Togo Respirory and Lung Diseases Service of CHU SO Lomé Togo Internal Medicine Service of CHU SO Lomé Togo

Objective: To determine the incidence of tuberculosis in person living with HIV infected by latent TB and under antiretroviral (ARV) therapy. Method: We studied prospectively for 36 months the occurrence of bacilliform pulmonary tuberculosis in patients infected with HIV, naive of BCG and receiving antiretroviral treatment. Each patient had an intradermal reaction (IDR) of 10 IU tuberculin Mérieux. The measurement of the nodule is made 72 hours later. During follow-up, patients were reviewed every six months for active tuberculosis. Results: A total of 212 out of 257 patients had an IDR greater than 5 mm, an ITL prevalence of 86.33%. Three patients were lost to follow-up during the study. The predominant female sex is 69.81%. The mean age was 42.8 ± 10.02 years. A previous history of tuberculosis was found in 14.15% of patients and 208 patients (98.11%) had HIV1. In 39.15% of patients, patients had a CD4 count lower than 350 cells/mm3 at baseline in the study. At the end of the three-year follow-up, among the 14 patients, 11 had failed ARV therapy and had developed TB, with an incidence of 2.20 cases per 100 patients. Conclusion: The incidence of active tuberculosis in ltbi was very high in HIV-positive patients with low CD4 count, hence the importance of reliable ltbi screening such as gamma interferon is better than patient follow-up.

关键词： ltbi Incidence Tuberculosis HIV

TST、TB⁃Ab、IGRA三种检测方法在尘肺合并ltbi诊断中的应用价值

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

分子诊断与治疗杂志 2022年第5期14卷 773-776页

作者：吴志伟张秀华闫志伟陈娜温陈勇项保利河北省张家口市肺科医院呼吸内科河北张家口075441 河北北方学院附属第一医院呼吸内科河北张家口075000

目的探讨皮肤结核菌素试验(TST)、人结核杆菌抗体(TB⁃Ab)、γ⁃干扰素释放试验(IGRA)三种检测方法对提高尘肺合并潜伏性结核感染(ltbi)诊断效率的应用价值。方法选取张家口市肺科医院2018年1月至2019年1月就诊的150例符合条件的尘肺患者... 详细信息

目的探讨皮肤结核菌素试验(TST)、人结核杆菌抗体(TB⁃Ab)、γ⁃干扰素释放试验(IGRA)三种检测方法对提高尘肺合并潜伏性结核感染(ltbi)诊断效率的应用价值。方法选取张家口市肺科医院2018年1月至2019年1月就诊的150例符合条件的尘肺患者为研究对象,所有患者均接受TST、TB⁃Ab、IGRA检测,比较三种方法检测的阳性率情况,比较不同期别尘肺的阳性率结果及在不同期别尘肺中具体数值。结果TST的阳性率为36.67%,TB⁃Ab的阳性率为30.67%,IGRA的阳性率为54.67%,IGRA阳性率较高。IGRA与TST和TB⁃Ab的阳性率比较,差异有统计学意义(P0.05);尘肺贰期和尘肺叁期时IGRA与TST阳性率比较,差异有统计学意义(P0.05)。随着尘肺期别的升高,TST的阳性反应程度有所下降,TB⁃Ab和IGRA的阳性数值呈正性增长。结论TST和TB⁃Ab临床仍值得作为尘肺合并ltbi的常规筛查方式,IGRA检测可明显提高尘肺合并ltbi诊断效率,值得在临床中的进一步推广和应用。

关键词： TST TB⁃Ab IGRA 尘肺 ltbi

Screening of Serum Biomarkers for Distinguishing between Latent and Active Tuberculosis Using Proteome Microarray

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2018年第7期31卷 515-526页

作者： CAO Shu Hui CHEN Yan Qing SUN Yong LIU Yang ZHENG Su Hua ZHANG Zhi Guo LI Chuan You Department of Bacteriology and Immunology Beijing Key Laboratory on Drug-Resistant Tuberculosis Research Beijing Tuberculosis and Thoracic Tumor Research Institute/Beijing Chest Hospital Capital Medical University. Beijing 101149 China Department of Laboratory Center Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 China Department of Clinical Laboratory Beijing Tuberculosis and Thoracic Tumour Research Institute/Beijing Chest Hospital Capital Medical University Beijing 101149 China Department of Epidemiological Research Beijing Tuberculosis and Thoracic Tumour Research lnstitute/Beijing Chest Hospital Capital Medical University Beijing 101149 China Institute of Tuberculosis Prevention and Control of District Changping Beijing 102200 China

Objective To identify potential serum biomarkers for distinguishing between latent tuberculosis infection（ltbi） and active tuberculosis（TB）. Methods A proteome microarray containing 4,262 antigens was used for screening serum biomarkers of 40 serum samples from patients with ltbi and active TB at the systems level. The interaction network and functional classification of differentially expressed antigens were analyzed using STRING 10.0 and the TB database, respectively. Enzyme-linked immunosorbent assays（ELISA） were used to validate candidate antigens further using 279 samples. The diagnostic performances of candidate antigens were evaluated by receiver operating characteristic curve（ROC） analysis. Both antigen combination and logistic regression analysis were used to improve diagnostic ability. Results Microarray results showed that levels of 152 Mycobacterium tuberculosis（Mtb）-antigenspecific IgG were significantly higher in active TB patients than in ltbi patients（P 〈 0.05）, and these differentially expressed antigens showed stronger associations with each other and were involved in various biological processes. Eleven candidate antigens were further validated using ELISA and showed consistent results in microarray analysis. ROC analysis showed that antigens Rv2031 c, Rv1408, and Rv2421 c had higher areas under the curve（AUCs） of 0.8520, 0.8152, and 0.7970, respectively. In addition, both antigen combination and logistic regression analysis improved the diagnostic ability. Conclusion Several antigens have the potential to serve as serum biomarkers for discrimination between ltbi and active TB.

关键词： ltbi Active TB Proteome microarray Serum biomarkers

在线全文

学校读者我要写书评

暂无评论

小儿隐性结核感染最佳治疗方案探讨

临床儿科杂志 2006年第2期24卷 154-156页

作者：万莉雅(综述) 范永琛(审校) 天津市儿童医院结核呼吸科天津300074

全世界有20亿人口感染隐性结核,是世界范围内结核病流行的最危险根源。85%－90%新被诊断的活动性肺结核,系由PPD阳性的隐性结核感染(ltbi)演变而来。海地1例30岁妇女怀孕前2年PPD硬结直径20mm,胸片(-),无结核中毒症状,未按ltbi给予抗结... 详细信息

全世界有20亿人口感染隐性结核,是世界范围内结核病流行的最危险根源。85%－90%新被诊断的活动性肺结核,系由PPD阳性的隐性结核感染(ltbi)演变而来。海地1例30岁妇女怀孕前2年PPD硬结直径20mm,胸片(-),无结核中毒症状,未按ltbi给予抗结核治疗。2年后产一男婴,出生44d后出现发热被诊为先大性结核病。母产前1周出现惊厥,诊为脑结核,母与其子均经结核菌检阳性证明为结核,因为母亲未及时治疗ltbi所致。[第一段]

关键词：隐性结核感染最佳治疗方案世界范围内小儿活动性肺结核结核中毒症状 ltbi 抗结核治疗结核病 D阳性

Enhancement of antitumor immunity by low-dose total body irradiation is associated with selectively decreasing the proportion and number of T regulatory cells

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2010年第2期7卷 157-162页

作者： Shudao Xiong Lei Zhang Yiwei Chu Department of Immunology Shanghai Medical College Institute for Immunobiology Key Laboratory of Molecular Medicine of Ministry of Education Fudan University ShanghaiChina

Low-dose total body irradiation （ltbi） is used in the treatment of some cancers mainly for immune enhancement rather than cell killing. However, the mechanism underlying ltbi remains unknown. In this study, by analyzing the immune patterns of lymphocytes, we found that the percentage and absolute number of CD4^＋CD25^＋Foxp3^＋ regulatory T cells are markedly decreased in naive mice following treatment with ltbi. On the contrary, the CD4^＋CD44^＋/CD8^＋CD44^＋ effector-memory T cells are greatly increased. Importantly, naive mice treated with dendritic cell-gp100 tumor vaccines under ltbi induced an enhancement of antigen-specific proliferation and cytotoxicity as well as interferon-γ, （IFN-γ） secretion against FIO melanoma tumor challenge, compared to treatment with either the tumor vaccine or ltbi alone. Consequently, the treatment resulted in a reduced tumor burden and prolonged mouse survival. Our data demonstrate that ltbi＇s enhancement of antitumor immunity was mainly associated with selectively decreasing the proportion and number of T regulatory cells, implying the potential application of the combination of ltbi and a tumor vaccine in antitumor therapy.

关键词： CD4^+CD25^+Foxp3^+ T cells CD4^+CD44^+/CD8^+CD44^+ effector-memory T cells low-dose total body irradiation ltbi tumor vaccine

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

结核分枝杆菌潜伏性感染相关抗原的研究进展

中华微生物学和免疫学杂志 2015年第1期35卷 59-64页

作者：吉萍范小勇吴康卢水华复旦大学附属公共卫生临床中心上海201508 复旦大学上海医学院上海200032

结核病（Tuberculosis， TB）是由结核分枝杆菌（Mycobacterium tuberculosis， Mtb）感染引起的传染性疾病。全世界范围内约1／3的人为结核分枝杆菌潜伏性感染（ latent TB infection， ltbi），其中10％的ltbi感染者最终会发展为活动... 详细信息

结核病（Tuberculosis， TB）是由结核分枝杆菌（Mycobacterium tuberculosis， Mtb）感染引起的传染性疾病。全世界范围内约1／3的人为结核分枝杆菌潜伏性感染（ latent TB infection， ltbi），其中10％的ltbi感染者最终会发展为活动性结核［1］。 ltbi感染者体内的Mtb通常以休眠菌的形式存在巨噬细胞内，通过改变自身特征和代谢途径适应宿主体内环境长期存活于人体内。

关键词：结核分枝杆菌潜伏性感染相关抗原 Tuberculosis tuberculosis ltbi 体内环境传染性疾病

Prevalence and Clinical Relevance of Schistosoma mansoni Co-Infection with Mycobacterium tuberculosis: A Systematic Literature Review

在线全文

学校读者我要写书评

暂无评论

Open Journal of Epidemiology 2023年第1期13卷 97-111页

作者： Bocar Baya Bourahima Kone Amadou Somboro Ousmane Kodio Anou Moise Somboro Bassirou Diarra Fah Gaoussou Traore Drissa Kone Mama Adama Traore Mahamadou Kone Antieme Georges Togo Yeya Sadio Sarro Almoustapha Maiga Mamoudou Maiga Yacouba Toloba Souleymane Diallo Robert L. Murphy Seydou Doumbia University Clinical Research Center (UCRC) of the University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali Service of Pneumopthisiology of the University Teaching Hospital of Point G Bamako Mali Clinical Laboratory of the University Teaching Hospital of Point G Bamako Mali Havey Institute for Global Health (Havey IGH) Northwestern University (NU) Chicago USA

Tuberculosis disease stands for the second leading cause of death worldwide after COVID-19, most active tuberculosis cases result from the reactivation of latent TB infection through impairment of immune response. Several factors are known to sustain that *** mansoni, a parasite of the helminth genus that possesses switching power from an immune profile type Th1 to Th2 that favors reactivation of latent TB bacteria. The aim of the study was to assess the prevalence of the co-infection between the two endemic infections. Systematic literature was contacted at the University Clinical Research Center at the University of Sciences, Techniques, and Technologies of Bamako in Mali. Original articles were included, and full texts were reviewed to assess the prevalence and better understand the immunological changes that occur during the co-infection. In total, 3530 original articles were retrieved through database search, 53 were included in the qualitative analysis, and data from 10 were included in the meta-analysis. Prevalence of the co-infection ranged from 4% to 34% in the literature. Most of the articles reported that immunity against infection with helminth parasite and more specifically Schistosoma mansoni infection enhances latent TB reactivation through Th1/Th2. In sum, the impact of Schistosoma mansoni co-infection with Mycobacterium tuberculosis is under-investigated. Understanding the role of this endemic tropical parasite as a contributing factor to TB epidemiology and burden could help integrate its elimination as one of the strategies to achieve the END-TB objectives by the year 2035.

关键词： Schistosoma mansoni Tuberculosis Co-Infections ltbi Reactivation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

结核分枝杆菌潜伏感染的化学预防干预

中华结核和呼吸杂志 2016年第1期39卷 13-15页

作者：沙巍同济大学附属上海市肺科医院结核病临床研究中心上海市结核病肺重点实验室 200433

2015年世界卫生组织在“MTB潜伏感染（latent TB inaction，ltbi）诊治指南”中，将ltbi定义为没有活动性结核病的临床表现，但机体持续存在对MTB抗原刺激的免疫应答的一种状态。虽然目前缺乏检测ltbi的直接手段和诊断“金标准”，但对... 详细信息

2015年世界卫生组织在“MTB潜伏感染（latent TB inaction，ltbi）诊治指南”中，将ltbi定义为没有活动性结核病的临床表现，但机体持续存在对MTB抗原刺激的免疫应答的一种状态。虽然目前缺乏检测ltbi的直接手段和诊断“金标准”，但对于ltbi进行化学预防，是防治ltbi发展为活动性结核病的有效干预措施，结论较为肯定，尤其是在特定的人群中。

关键词：潜伏感染化学预防结核分枝杆菌预防干预活动性结核病 ltbi 世界卫生组织 “金标准”

Efficacy and safety of prophylactic treatment on activation of latent tuberculosis during glucocorticoid therapy in patients with rheumatic disease

在线全文

学校读者我要写书评

暂无评论

Efficacy and safety of prophylactic treatment on activation ...

IRG1 mRNA定量检测对结核感染诊断的价值

第十二届全国免疫学学术大会

作者： Shi Linhong Wu Rui The First Affiliated Hospital of Nanchang University

Objective:Individuals that *** latent tuberculosis infection(ltbi)proceed to active disease are *** aimed to analyse the risk factors of ltbi patients with rheumatic diseases during glucocorticoid therapy.

关键词： ltbi rheumatic disease glucocorticoid

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国免疫学杂志 2015年第5期31卷 667-669,673页

作者：曹志红曹彦程小星解放军第三0九医院全军结核病研究所/全军结核病防治重点实验室结核病诊疗新技术北京市重点实验室北京100091

目的:研究活动性肺结核患者外周血单个核细胞(PBMCs)经结核特异性抗原刺激后免疫应答基因1(Immuno-responsive gene 1,IRG1)的mRNA表达情况并与结核潜伏感染(Latent tuberculosis infection,ltbi)及非结核感染健康对照组进行比较。方法... 详细信息

目的:研究活动性肺结核患者外周血单个核细胞(PBMCs)经结核特异性抗原刺激后免疫应答基因1(Immuno-responsive gene 1,IRG1)的mRNA表达情况并与结核潜伏感染(Latent tuberculosis infection,ltbi)及非结核感染健康对照组进行比较。方法:提取研究对象的PBMCs,经特异性抗原肽刺激后,收集细胞并提取总RNA然后经实时荧光定量PCR检测技术比较各组IRG1 mRNA表达情况。然后以敏感性(Sensitivity)为纵坐标,1-特异性(1-specificity)为横坐标绘制结核感染组(活动性肺结核+ltbi)和非结核感染健康对照组相比较的ROC曲线。结果:经结核特异性抗原刺激后,健康对照组PBMCs中IRG1基因mRNA的相对表达量明显低于结核组和潜伏感染组,差异有统计学意义(P<0.05)。ROC曲线下面积为0.91。以0.015 36为临界值,鉴别结核感染和非结核感染健康对照的敏感性和特异性分别为76.47%和96.30%,此时阳性似然比等于20.65,85.2%的病例诊断准确。结论:IRG1可能有助于诊断结核感染。

关键词：结核趋化因子 IRG1 ltbi