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Neurotoxicity of the pesticide rotenone on neuronal polarization: a mechanistic approach

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Neural Regeneration Research 2019年第5期14卷 762-766页

作者： Mariano Bisbal Mónica Sanchez Laboratory of Neurobiology Instituto Mercedes y Martín Ferreyra (INIMEC-CONICET) Universidad Nacional de Córdoba Instituto Universitario Ciencias Biomédicas Córdoba

Neurons are the most extensive and polarized cells that display a unique single long axon and multiple dendrites, which are compartments exhibiting structural and functional differences. Polarity occurs early in neuronal development and it is maintained by complex subcellular mechanisms throughout cell life. A well-defined and controlled spatio-temporal program of cellular and molecular events strictly regulates the formation of the axon and dendrites from a non-polarized cell. This event is critical for an adequate neuronal wiring and therefore for the normal functioning of the nervous system. Neuronal polarity is very sensitive to the harmful effects of different factors present in the environment. In this regard, rotenone is a crystalline, colorless and odorless isoflavone used as insecticide, piscicide and broad spectrum pesticide commonly used earlier in agriculture. In the present review we will summarize the toxicity mechanism caused by this pesticide in different neuronal cell types, focusing on a particular biological mechanism whereby rotenone could impair neuronal polarization in cultured hippocampal neurons. Recent advances suggest that the inhibition of axonogenesis produced by rotenone could be related with its effect on microtubule dynamics, the actin cytoskeleton and their regulatory pathways, particularly affecting the small RhoGTPase RhoA. Unveiling the mechanism by which rotenone produces neurotoxicity will be instrumental to understand the cellular mechanisms involved in neurodegenerative diseases influenced by this environmental pollutant, which may lead to research focused on the design of new therapeutic strategies.

关键词： rotenone environmental pollutants toxicity neuronal polarity RhoGTPase RhoA lfc Arhgef1

ON FULLY CONVEX AND LOCALLY FULLY CONVEX BANACH SPACE*

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Acta Mathematica Scientia 1990年第3期10卷 327-343页

作者：那启元 Dept. of Math. Nankai Univ. Tianjin China

In this paper, we introduce the concept of locally fully convexity. We study the properties of fully convex and locally fully convex Banach spaces and the relations between them. We also give some applications of the ... 详细信息

关键词： lfc Th lim ON FULLY CONVEX AND LOCALLY FULLY CONVEX BANACH SPACE

EMP Formation in the Co(Ⅱ)Doped ZnTe Nanowires

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Chinese Physics Letters 2018年第3期35卷 93-96页

作者：刘玉婷侯丽鹏邹双阳张黎梁变变郭永昌 Arfan Bukhtiar Muhammad Umair Farooq 邹炳锁 Beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronics System Beijing Institute of Technology

Co（Ⅱ） doped ZnTe nanowires are prepared by a thermal evaporation method. The power and temperature dependent micro-photoluminescence spectra of single nanowire demonstrate the double bands near its band edge, and the ferromagnetism behavior for these nanowires is identified. The occurrence of excitonic magnetic polaron （EMP） can account for the second emission band for its higher binding energy and ferromagnetic coupling. This EMP formation in a nanostructure will facilitate to realize magnetic modulation on confined excitons and will find new applications for spinpolarized nanophotonie devices.

关键词： EMP Formation in the Co Co Zn Te Doped ZnTe Nanowires lfc

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三元序链的优化理论

系统工程理论与实践 1991年第3期 67-72页

作者：乞建勋王广庆华北电力学院

日本人加藤昭吉提出的K·S法,虽在国际上广为流行,但因其只根据机动时间的多少决定工序顺序的先后序顺,因此在大多数情况下只能得到较优的方案,而不能得到最优的方案。本文证明了决定工序顺序优劣不仅仅与机动时间有关,还与最早开始时... 详细信息

日本人加藤昭吉提出的K·S法,虽在国际上广为流行,但因其只根据机动时间的多少决定工序顺序的先后序顺,因此在大多数情况下只能得到较优的方案,而不能得到最优的方案。本文证明了决定工序顺序优劣不仅仅与机动时间有关,还与最早开始时间和工期有关。文中最后给出了具体的判断方法。

关键词： EFA 代表总工期 LSC lfc 机动时间平行工序 EFB 优化理论 BCA 定理 LFB 系统工程理论与实践

PI Multi-Objective Genetic for lfc Based Different Wind Penetration

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Journal of Power and Energy Engineering 2018年第7期6卷 76-91页

作者： Gaber El-Saady El-Nobi A. Ibrahim A. A. Donkol Electrical Engineering Department Faculty of Engineering Assiut University Assiut Egypt Communication and Computer Engineering Department Faculty of Engineering Nahda University Beni Suef Egypt

Future energy descent systems will be expected to be controlled by the using of renewable power sources of which wind energy is one of the favorable sources. This paper treats with the implantation of genetic algorithms for making the parameters needed for PID applied to interconnected thermal and hydraulic power systems at best use and most effective. Two-areas of hydraulic and thermal power systems with wind connected parallel to each one are considered to exemplify the effective parameter investigation. First hydraulic and thermal are connected with tie line with the wind connected parallel to hydraulic or thermal, and then disturbance was made at thermal power plant, then to hydraulic power plant. Simulations are performed aided by the integrated Simulink/Matlab environment taking into consideration the genetic optimization process. Multiple integral representations variables with different cost functions were considered in the search for the effective AGC parameters. The outcomes established by this paper shows the impact of the genetic algorithms for lfc about multiple areas connected power systems based on different wind power using in the tuning of such a process.

关键词： PID Wind Genetic Multi-Objective Genetic Algorithm lfc

Recent Development of Lost Foam Casting Technology Comment on the 7th Chinese Lost Foam Casting Symposium

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China Foundry 2006年第3期3卷 224-228页

作者： LIU Zi-li (College of Material Science & Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China) College of Material Science & Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

The 7th Chinese Lost Foam Casting (lfc) Symposium & the 1st lfc Technology Exposition were held on May 21-23 at Nanjing University of Aeronautics and Astronautics (NUAA), and the conference theme was "Recent development of lost foam casting technology". Prof. TAO Jie, the Executive Chairman of the conference and the Vice Director of lfc Committee of Foundry Institution of Chinese Mechanical Engineering Society(FICMES), chaired the inauguration. Prof. NIE Hong, the Vice President of NUAA, represented the host address and expressed welcome and gratitude to all the guests from home and abroad. He said the development of the technologies, environmental protection and the trade globalization require to continually improve the performance of products, and accurately select proper material and the manufacturing technology. As the revolutionary technology in casting development history, lfc technology has brought a brand-new change for the machine design and casting production. He hoped the conference would be beneficial to the development of Chinese lfc technololy and wished the symposium a complete success! Prof. YE Sheng-ping, the Executive Chairman of the conference and the Director of lfc Committee of FICMES, gave the opening address and read out the congratulations of F. J. Woestmann (Director of Germany lfc Technology Council), Wolfgang (General Manager of Storopack Hans Reichenecker Group), G Sedlmair Heiko (lfc project director of Teubert Maschinenbau GmbH), etc. Patrice Juton, the Sale Manager of Storopack Group, gave a speech on behalf of the conference delegates.

关键词： Co Cast lfc Recent Development of Lost Foam Casting Technology Comment on the 7th Chinese Lost Foam Casting Symposium

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美国lfc低阶煤提质联产油技术新进展

中国矿业 2010年第12期19卷 82-87页

作者：李青松李如英马志远陈金庆中国石油大学(华东) 山东青岛266555

本文回顾了美国lfc技术的发展历程,重点介绍了lfc技术以及在该技术基础上改进的CCI技术的工艺,并简要介绍了lfc技术在中国的应用及发展。通过与国际同类技术比较,结合我国劣质煤资源现状,综合分析认为,lfc及其改进的技术可作为成熟先进... 详细信息

本文回顾了美国lfc技术的发展历程,重点介绍了lfc技术以及在该技术基础上改进的CCI技术的工艺,并简要介绍了lfc技术在中国的应用及发展。通过与国际同类技术比较,结合我国劣质煤资源现状,综合分析认为,lfc及其改进的技术可作为成熟先进的煤提质转油技术,推动我国低阶煤加工工业发展。

关键词：低阶煤褐煤煤提质煤转油 lfc

Developing Oral Competence in English as a Lingua Franca in Chinese Context

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校园英语 2015年第28期 21-22页

作者：苏旭丽 Longdong University

English has been used in diverse contexts internationally as a lingua franca.It has become a necessary tool for people from different language backgrounds to communicate with each other.Native-speaker competence is no longer viewed as a realistic goal for English learners to achieve.Therefore,in line with this view a more appropriate pedagogy is needed especially in the field of speaking.This article addresses the ways of developing oral competence from three perspectives:lfcbased pronounciation,pragmatic stragegies and intercultural competence.Then it concludes with an exploring of implications for ELF teaching in Chinese context.

关键词： oral competence EL lfc pragmatic strategies intercultural competence

Lingua Franca Core: The Challenges of Specifying a Set of Phonological Features for English Learners

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海外英语 2013年第23期 317-318页

作者：曾天娇 English Department Guiyang Medical University

Last decade witnesses the rethinking of traditional English teaching models for non-native speakers.The proposed new model—English as Lingua Franca(ELF)sheds light on what the non-native English learners really need to learn in the global setting,instead of constant following of the standard RP/GA norm.Though of much significance among the English users in the Expanding Circle,the new model faces no less challenges,especially in its phonological proposal—lfc.A discussion of these challenges is important to English language educators,for the implementation of ELF model relies on the solution of these potential problems.

关键词： lfc expanding circle,phonological features challen