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Application of analytical instruments in pharmaceutical analysis

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Journal of Pharmaceutical Analysis 2013年第4期 303-305页

关键词： lcms MRM

Application of analytical instruments in pharmaceutical analysis

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Journal of Pharmaceutical Analysis 2014年第6期4卷 I0001-I0002,F0003,F0004页

lcms-8040lcms-8040 incorporates newly improved ion optics and collision cell technology to provide higher multiple reaction monitoring （MRM） sensitivity. These improvements also yield higher sensitivity for scan mod... 详细信息

关键词： high lcms MRM

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Application of analytical instruments in pharmaceutical analysis

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Journal of Pharmaceutical Analysis 2014年第4期 295-298页

lcms-8040lcms-8040 incorporates newly improved ion optics and collision cell technology to provide higher multiple reaction monitoring(MRM)*** improvements also yield higher sensitivity for scan mode measurements,expanding the potential range of LC/MS/MS ***-High Reliability MRM optimization in Shimadzu’s lcms systems is based on a rapid series of automated flow injection analyses,requiring only minutes to *** compounds can be optimized in an unattended sequence,freeing the analyst from tedious *** parameters

关键词： high lcms MRM

Application of analytical instruments in pharmaceutical analysis

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Journal of Pharmaceutical Analysis 2015年第5期5卷 I0001-I0004页

lcms-8050Continuing the evolution of Shimadzu’s UF technology,Shimadzu introduces the lcms-8050 triple quadrupole mass spectrometer,offering unparalleled measurement speeds and high-sensitivity *** high performance o... 详细信息

关键词： GCMS UF UHPLC lcms

Application of analytical instruments in pharmaceutical analysis

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Journal of Pharmaceutical Analysis 2014年第3期4卷 I0001-I0002,F0003,F0004页

lcms-8040lcms-8040 incorporates newly improved ion optics and collision cell technology to provide higher multiple reaction monitoring （MRM） sensitivity.

关键词： MRM lcms high GCMS

Application of analytical instruments in pharmaceutical analysis

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Journal of Pharmaceutical Analysis 2014年第5期 351-354页

关键词： MRM lcms high GCMS

Application of analytical instruments in pharmaceutical analysis

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Journal of Pharmaceutical Analysis 2013年第6期 460-463页

lcms-8040lcms-8040 incorporates newly improved ion optics and collision cell technology to provide higher multiple reaction monitoring(MRM)*** improvements also yield higher sensitivity for scan mode measurements,expanding the potential range of LC/MS/MS *** papers by using lcms-8040Marta Rodriguez-Aller,Robert Gurny,Jean-Luc Veuthey,Davy *** ultra high-pressure liquid chromatography with mass spectrometry:

关键词： lcms MRM high GCMS

Application of analytical instruments in pharmaceutical analysis

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Journal of Pharmaceutical Analysis 2014年第3期 223-226页

关键词： lcms MRM

Case Study: Suicide Attempt by Intentional Ingestion of Chlormequat

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Forensic Medicine and Anatomy Research 2015年第2期3卷 39-42页

作者： Guanghua Yang Djemila Kechkeche Hafid Belhadj-Tahar Alexandre Verdu Nouredine Sadeg School of Medicine Tongji University Shanghai China Departement of Chemistry University of Pierre et Marie-Curie Paris France Bruker France Marne La Valée France AFPreMed Toxicology Research Group Toulouse France

Chlormequat is a quaternary ammonium and choline chlorinated derivated is used as plant growth regulating agent. There are very few documented cases of poisoning in humans. We reported a case of non-fatal suicide attempt by chlormequat in France. A 34-year-old woman was admitted to hospital after deliberate consumption of plant growth regulator, C5 SUN, containing chlormequat chloride (460 g/L) and choline chloride (320 g/L). Immediately, she developed symptoms of respiratory distress and a cardiac massage was begun by her father. In this case report, we described the method for an accurate and reliable screening of chlormequat which was based on the combination of Target Analysis powerful software and a high performance TOF-MS (Impact HD from Bruker). After forced diuresis, the kinetic of elimination of chlormequat is biphasic: vascular phase diffusion (half-life of 5.6 hr) followed by a phase of free elimination (half-life of 16.2 h). Although chlormequat poisoning is clinically similar to that observed with anticholinesterase compounds, chlormequat chloride is not an acetylcholinesterase inhibitor. Chlormequat seems to be a weak substrat competitor for cholinesterase leading to acetylcholine accumulation and prolonged depolarization in muscular junction. Cardiac massage, artificial respiration and forced diuresis have significantly improved the prognosis of our patient.

关键词： Chlormequat Suicide Poisoning Diuresis Toxicokinetic lcms