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Protective effects of docosahexaenoic acid against non-alcoholic hepatic steatosis through activating of JAK2/STAT3 signaling pathway

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BIOcell 2021年第2期45卷 307-316页

作者： YUE WANG YINPING DUAN KUNlIN CHEN HUIXIA lI YAN QUAN College of Animal Science and Technology Nanjing Agricultural UniversityNanjing210095China 2 Nanjing XinRuize Agricultural Biotechnology Co. Ltd.Nanjing210095China Jiangsu Key laboratory for Food Quality and Safety-State Key laboratory Cultivation Base Ministry of Science and TechnologyJiangsu Academy of Agricultural SciencesNanjing210014China College of Pharmacy Shaanxi University of Chinese MedicineXianyang712046China

Non-alcoholic fatty liver disease is the most common cause of hepatic *** the present study,human normal hepatocyte l02 cells were treated with 50%fetal bovine serum to induce the formation of hepatic steatosis in vitro,and then the cells were treated with docosahexaenoic acid to investigate its protective effect on Non-alcoholic fatty liver *** results showed that 50%of fetal bovine serum significantly induced intracellular lipid accumulation and hepatocyte fatty degeneration within 48 *** expression level of adipose formation-related genes was significantly up-regulated,such as PPARγ,C/EBPαand SREBP-1;meanwhile,the content of cellular total lipid,total cholesterol and triglycerides were significantly increased after 50%fetal bovine serum ***,docosahexaenoic acid treatment could inhibit FBS-induced intracellular lipid accumulation in l02 cells and the expression of lipogenic ***,docosahexaenoic acid treatment could reduce hepatic steatosis-induced oxidative stress and endoplasmic reticulum stress response,and these responses were shown by the modification of antioxidant enzyme activities and GRP78,CHOP *** addition,the results showed that docosahexaenoic acid can activate the JAK2/STAT3 signaling pathway in fatty liver l02 cell;inhibition of JAK2/STAT3 signaling pathway by WP1066 abolished the beneficial effects of docosahexaenoic acid on hepatic steatosis accompanied with the increased expression of lipogenic genes and endoplasmic reticulum stress *** all,the present study showed that docosahexaenoic acid can alleviate non-alcoholic hepatic steatosis by activating JAK2/STAT3 signaling pathway.

关键词： Docosahexaenoic acid NAFlD l02 cell lipid accumulation JAK2/STAT3

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