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Coordination behavior between zinc salts and l-α-methionine

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Chinese Science Bulletin 1998年第18期43卷 1527-1531页

作者： Shengli Gao Jianrui liu Mian Ji Xuwu Yang Fengxing Zhang Zhongjin li Department of Chemistry Northwest University Xi’an China Department of Chemical Engineering Northwest Institute of Light Industry Xianyang China

The solubility properties of ZnCl\-2/ZnAc\-2/ZnSO\-4MetH\-2O systems at 25℃ in the whole cocentration range have been investigated by phase equilibrium method. The results indicate that ZnAc\-2 and ZnSO\-4 systems are both simple systems, which do not exist any compound; there are 2 complexes formed in ZnCl\-2 system: Zn（Met）Cl\-2 and Zn（Met）\-2Cl\-2·2H\-2O. Under the direction of phase equilibrium result, 2 solid complexes have been prepared in water and characterized by chemical analysis, IR, Xray diffraction. Their combustion energies have also been determined by means of a RBCtype1 rotatingbomb calorimeter, and their standard enthalpies of formation, Δ f, coor（s）H O-, have been calculated which are （-828.32±3.00） kJ·mol -1 and （-1 117.08±6.15） kJ·mol -1, respectively.

关键词： zinc salts l-methionine phase equilibrium complex standard formation enthalpy.

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methionine sources and genotype affect embryonic intestinal development, antioxidants, tight junctions, and growth-related gene expression in chickens

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Animal Nutrition 2024年第1期16卷 218-230页

作者： James K.lugata Sawadi F.Ndunguru Gebrehaweria K.Reda Xénia E.Ozsváth Eszter Angyal levente Czeglédi Gabriella Gulyás Renáta Knop János Oláh Zoltán Mészár Rita Varga Brigitta Csernus Csaba Szabó Department of Animal Nutrition and Physiology Faculty of Agriculture and Food Sciences and Environmental Management University of Debrecen Faculty of Agriculture and Food Sciences and Environmental Management Doctoral School of Animal Science University of Debrecen Department of Animal Husbandry Faculty of Agriculture and Food Sciences and Environmental Management University of Debrecen Department of Evolutionary Zoology and Human Biology Faculty of Science and Technology University of Debrecen Institutes for Agricultural Research and Educational Farm University of Debrecen Department of Anatomy Histology and Embryology Faculty of Medicine University of Debrecen

methionine(Met) is an essential and first limiting amino acid in the poultry diet that plays a significant role in chicken embryonic development and growth. The present study examined the effect of in ovo injection of Dl-Met and l-Met sources and genotypes on chicken embryonic-intestinal development and health. Fertilized eggs of the two genotypes, TETRA-Sl layer hybrid(TSl)—commercial layer hybrid and Hungarian Partridge colored hen breed(HPC)—a native genotype, were randomly distributed into four treatments for each genotype. The treatment groups include the following: 1) control non-injected eggs(NoIn); 2) saline-injected(SaIn); 3) Dl-Met injected(DlM); and 4) l-Met injected(lM). The in ovo injection was carried out on 17.5 d of embryonic development; after hatching, eight chicks per group were sacrificed, and the jejunum was extracted for analysis. The results showed that both DlM and lM groups had enhanced intestinal development as evidenced by increased villus width, villus height, and villus area(P l. The DlM group had significantly reduced crypt depth, glutathione(GSH) content, glutathione S-transferase 3 alpha(GST3), occludin(OClN) gene expression and increased villus height to crypt depth ratio in the TSl genotype than the lM group(P lin-like growth factor 1(IGF1) gene, tricellulin(MD2), occludin(OClN),superoxide dismutase 1(SOD1), and GST3 genes than the TSl genotype(P lusion, these findings showed that in ovo injection of Met enhanced intestinal development, and function, with genotypes responding differently under normal conditions. Genotypes also influenced the expression of intestinal antioxidants, tight junction, and growth-related genes.

关键词： Dl-methionine l-methionine In ovo injection Intestinal development Poultry

A Facile Synthetic Route to l-Phosphinothricin

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Chinese Chemical letters 2006年第2期17卷 177-179页

作者： Xue Song XU Han Bing TENG Guo Fu QIU Shu Cai lIANG Xian Ming HU School of Pharmacy Wuhan University Wuhan 430072

A convenient and effective method for synthesis of l-phosphinothricin was described. The highlight was involved in a simple access to the key intermediate l-2-amino-4-chlorobutyric acid derivative from the inexpensive... 详细信息

关键词： Synthesis l-methionine l-phosphinothricin.

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The in ovo injection of methionine improves intestinal cell proliferation and differentiation in chick embryos by activating the JAK2/STAT3 signaling pathway

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Animal Nutrition 2021年第4期7卷 1031-1038页

作者： Meng-Jie Chen Jia-Yi Zhou Yi-Jun Chen Xiu-Qi Wang Hui-Chao Yan Chun-Qi Gao College of Animal Science South China Agricultural University/Guangdong Provincial Key Laboratory of Animal Nutrition ControlGuangzhou510642China

The intestinal health of chick embryos is vital for their life-long growth,and exogenous nutrition intervention may provide sufficient nutrition for embryonic *** the present study,we investigated the effect of in ovo injection of l-methionine(l-Met)on the intestinal structure and barrier function of chick *** were 4 groups of treatments:the control(CON)group injected with phosphate-buffered saline(PBS)and the other 3 groups injected with 5,10,and 20 mg l-Met/egg,*** injection was performed on embryonic day 9(E9),and intestinal samples were collected on the day of hatching for *** results showed that,compared with the CON group,the groups administered an in ovo injection of l-Met increased relative weights of the duodenum,jejunum,and ileum(Plin and eosin(H&E)staining showed that the groups injected with 5,10,and 20 mg l-Met significantly increased villus height and crypt depth(Pl-Met also increased the transepithelial electrical resistance(TEER)of the jejunum(Pl-Met increased the expression of the tight junction proteins(ZO-1 and claudin-1)and the fluorescence signal intensity of Ki67 and villin proteins(Pl transducer and activator of transcription 3(p-STAT3)was significantly increased by 10 or 20 mg l-Met injection(Plusion,the injection of l-Met,especially at a dose of 10 mg,showed beneficial effects on the intestinal integrity of chick embryos due to the activation of the JAK2/STAT3 signaling *** results may provide new insights for regulating the intestinal development of embryonic chicks and the rapid growth of chicks after hatching.

关键词： In ovo injection Chick Intestine l-methionine JAK2/STAT3

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Amelioration of hepatotoxicity by biocleavable aminothiol chimeras of isoniazid: Design, synthesis, kinetics and pharmacological evaluation

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World Journal of Hepatology 2018年第7期10卷 496-508页

作者： Neha Vithal Bhilare Suneela Sunil Dhaneshwar Kakasaheb Ramoo Mahadik Department of Pharmaceutical Chemistry Poona College of Pharmacy Bharati Vidyapeeth University

AIM To overcome the hazardous effects on liver caused by long-term use of antitubercular agent isoniazid(INH) by developing a novel hepatoprotective prodrug strategy by conjugating INH with aminothiols as antioxidant promoities for probable synergistic *** INH was conjugated with N-acetyl cysteine(NAC) and N-(2)-mercaptopropionyl glycine using the SchottenBaumann reaction and with l-methionine using Boc-anhydride through a biocleavable amide linkage. Synthesized prodrugs were characterized by spectral analysis, and in vitro and in vivo release studies were carried out using HPlC. Their hepatoprotective potential was evaluated in male Wistar rats by performing liver function tests, measuring markers of oxidative stress and carrying out histopathology *** Prodrugs were found to be stable in acidic(pH 1.2) and basic(pH 7.4) buffers and in rat stomach homogenates, whereas they were hydrolysed significantly(59.43%-94.93%) in intestinal homogenates over a period of 6 h. Upon oral administration of prodrug NI to rats, 52.4%-61.3% INH and 47.4%-56.8% of NAC were recovered in blood in 8-10 h. Urine and faeces samples pooled over a period of 24 h exhibited 1.3%-2.5% and 0.94%-0.9% of NAC, respectively, without any presence of intact NI or INH. Prodrugs were biologically evaluated for hepatoprotective activity. All the prodrugs were effective in abating oxidative stress and re-establishing the normal hepatic physiology. The effect of prodrug of INH with NAC in restoring the levels of the enzymes superoxide dismutase and glutathione peroxidase and abrogating liver damage was noteworthy especially. CONClUSION The findings of this investigation demonstrated that the reported prodrugs can add safety and efficacy to future clinical protocols of tuberculosis treatment.

关键词： Aminothiols antioxidants N-acetyl cysteine N-(2-mercaptopropionyl)glycine isoniazid l-methionine liver injury tuberculosis

Catalytic Activity of Amino Acids-Metal Complexes in Oxidation Reactions

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Journal of Biomaterials and Nanobiotechnology 2013年第2期4卷 28-36页

作者： Krassimir Vassilev Sevdalina Turmanova Emilya Ivanova Victotia Trifonova Department of Biotechnology “Professor Assen Zlatarov” University Burgas Bulgaria Department of Inorganic Chemistry “Professor Assen Zlatarov” University Burgas Bulgaria Department of Materials Science “Pro- fessor Assen Zlatarov” University Burgas Bulgaria

Studies were carried out to determine the activity of complexes of the essential amino acids Dl-lysine and l-methionine with heavy metals in the oxidation of cyclohexene with tert-butylhydroperoxide in toluene at 80°C. All complexes were prepared through interaction of metal ions and Dl-lysine and l-methionine at room temperature in aqueous solutions. Only the complexes of Mo and W were obtained from acidic aqueous solution. These complexes were characterized by FT-IR, Moessbauer spectroscopy and EPR analysis. The products of the oxidation reactions were identified by GC/MS analysis. The complexes of Mo and V showed the best activity in the epoxidation reaction of cyclohexene in comparison with other complexes, such as Ni, Mn, Zn, Co, Cu, Cr, Fe and W. Using semi-empirical quantum-chemistry methods, the full energy of the Mo complexes was calculated and their probable structure is presented.

关键词： Dl-lysine l-methionine Metal Complexes Structure Properties Catalysis Oxidation

The Role of Abnormalities Related to the One Carbon Cycle in Depression and Schizophrenia

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Neuroscience & Medicine 2012年第1期3卷 101-106页

作者： John Smythies Center for Brain and Cognition UCSD

This paper reviews our present knowledge of the role of the one-carbon cycle in mood disorder and schizophrenia with particular attention to S-adenosyl methionine (SAM). After an historical introduction the clinical data is first reviewed of the anti-depressant action of SAM, in particular a survey of double blind placebo-controlled trials. Then follows an account of the biochemical parameters of the action of SAM, in particular the role of folic acid and 5-methyltetrahydrofolate (vitamin B9), polyamines, homocysteine, together with epigenetic studies. In schizophrenia the effect of oral l-methionine on worsening the symptoms of some chronic schizophrenics has been known since 1961. Recent epigenetic research covered has addressed the mechanism of this reaction. This includes the role of SAM in modulating DNA methyltransferase-1 mRNA activity, cytosine 5-methylation, spine numbers and the expression of mRNAs encoding for reelin and GAD67 in GABAergic neurons in the frontal cortex in schizophrenia. There is also evidence that marker D8S542 located within the methionine sulfoxide reductase (MSRA) gene may be involved in schizophrenia as well as 677C > T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene. The possible roles of homocysteine and methionine S-adenosyl transferase kinetics are also discussed.

关键词： One-Carbon Cycle S-Adenosyl methionine l-methionine B Vitamins schizophrenia Depression Homocysteine Reelin Epigenetics