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l-arginine Supplementation Mitigates Dichlorvos-Induced Haematocardiotoxicity, and Oxidative Stress in Male Wistar Rats

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Open Journal of Applied Sciences 2024年第7期14卷 1886-1903页

作者： Waidi Adeoye Saka Yusuff Dimeji Igbayilola Jabba Hamidu lawan Taoheed Kolawole Muftaudeen Ridwanullahi Adejumo Tolulope Deborah Alu Mary Ikuomola Joshua Tinuade Ojelere Victor Odufa Adegoke Department of Physiology College of Health Sciences Ladoke Akintola University of Technology Ogbomoso Oyo State Nigeria Department of Human Physiology College of Medicine and Health Sciences Baze University Abuja Nigeria Department of Biological Sciences Faculty of Computing and Applied Sciences Baze University Abuja Nigeria

Due to its toxicity, dichlorvos—a common organophosphate pesticide—poses significant risks to human health. This study utilized male Wistar rats to explore the potential protective effects of l-arginine supplementation against dichlorvos-induced toxicity, focusing on cardiotoxicity, haematotoxicity and oxidative stress. The rats were divided into four groups: Control, l-arginine (l), Dichlorvos (D), and l-arginine + Dichlorvos (l + D). Dichlorvos was administered to the D group, l-arginine (100 mg/kg) to the l group, and both l-arginine and dichlorvos to the l + D group. The study evaluated various parameters, including cardiovascular, oxidative stress markers, and haematological indices. Significant changes in haematological parameters such as haemoglobin (Hb), haematocrit (HCT), and red blood cell count (RBC) indicated haematotoxicity after dichlorvos administration. Additionally, elevated cardiac markers, including lactate dehydrogenase (lDH) and creatine kinase-MB (CK-MB), suggested cardiotoxic effects. Exposure to dichlorvos also resulted in decreased antioxidant enzyme levels and increased oxidative stress indicators like malondialdehyde (MDA). Remarkably, l-arginine supplementation mitigated the damage caused by dichlorvos. It normalized the altered haematological parameters, demonstrating its protective effect against haematotoxicity. The rise in cardiac markers was reduced with l-arginine supplementation, indicating protection against cardiotoxicity. Moreover, l-arginine significantly decreased oxidative stress, as evidenced by lower MDA levels and restored antioxidant enzyme activity. In conclusion, l-arginine supplementation in male Wistar rats showed promising protective effects against dichlorvos-induced cardiotoxicity, haematotoxicity and oxidative stress. This suggests that l-arginine may offer a beneficial intervention to mitigate the adverse effects of dichlorvos on blood and heart health, paving the way for potential treatments for pesticide poison

关键词： Dichlorvos l-arginine Cardiovascular Function Haematological Parameters Oxidative Stress

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l-arginine/nitric oxide regulates skeletal muscle development via muscle fibre-specific nitric oxide/mTOR pathway in chickens

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Animal Nutrition 2022年第3期10卷 68-85页

作者： Ruxia Wang Kelin li li Sun Hongchao Jiao Yunlei Zhou Haifang li Xiaojuan Wang Jingpeng Zhao Hai lin Key lab for Animal Biotechnology and Disease Control Department of Animal ScienceShandong Agricultural UniversityTai'an271000China Institute of Biological Resources Jiangxi Academy of SciencesNanchang330096China

l-arginine (l-Arg), the precursor of nitric oxide (NO), plays an important role in muscle function. Fasttwitchglycolytic fibres are more susceptible to age-related atrophy than slow-twitch oxidative *** effect of l-Arg/NO on protein metabolism of fast- and slow-twitch muscle fibres was evaluated inchickens. In Exp. 1, 48 chicks at 1 day old were divided into 4 groups of 12 birds and subjected to 4treatments: basal diet without supplementation or supplemented with 1% l-Arg, and water supplementedwith or without l-nitro-arginine methyl ester (l-NAME, 18.5 mM). In Exp. 2, 48 chicks weredivided into 4 groups of 12 birds fed with the basal diet and subjected to the following treatments: tapwater (control), tap water supplemented with l-NAME (18.5 mM), or molsidomine (MS, 0.1 mM), or18.5 mM l-NAME t 0.1 mM MS (NAMS). The regulatory effect of l-Arg/NO was further investigatedin vitro with myoblasts obtained from chicken embryo pectoralis major (PM) and biceps femoris (BF).In vivo, dietary l-Arg supplementation increased breast (t14.94%, P le mass(t23.40%, P le influence. However, l-NAME treatmentblocked the beneficial influence of l-Arg on muscle development. l-Arg decreased (P lated mTOR and ribosomal protein S6 kinase beta-1 (p70S6K) levels in breastmuscle, which was recovered by l-NAME treatment. In vitro, l-Arg or sodium nitroprusside (SNP)reduced protein synthesis rate, suppressed phosphorylated mTOR/p70S6K and decreased atrogin-1 andmuscle RING finger 1 (MuRF1) in myoblasts from PM muscle (P l-NAME abolished the inhibitoryeffect of l-Arg on protein synthesis and the mTOR/p70S6K pathway. However, myoblasts from BF muscleshowed the weak influence. Moreover, blocking the mTOR/p70S6K pathway with rapamycin suppressedprotein synthesis of the 2 types of myoblasts;whereas, the protein expression of atrogin-1 and MuRF1levels were restricted only in myobl

关键词： Muscle fibre l-arginine Nitric oxide/mTOR/p70S6K Atrogin-1 Muscle RING finger 1 Chicken

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l-arginine, the substrate of nitric oxide synthase,inhibits fertility of male rats

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Asian Journal of Andrology 2001年第2期3卷 97-103页

作者： W.D.Ratnasooriya M.G.Dharmasiri Department of Zoology University of Colombo Colombo 3 Sri LankaDepartment of Zoology University of Colombo Colombo 3 Sri Lanka

Aim: To examine the effect of l-arginine, the substrate of nitric oxide (NO) synthase, on reproductive function ofmale rats. Methods: Male rats were gavaged with either l-arginine (100 or 200 mg·kg^(-1)·d^(-1)), D-arginine (200mg·kg^(-1)·d^(-1)) or vehicle (0.9% NaCl) for seven consecutive days. Their sexual behaviour and fertility were evaluat-ed using receptive females. Results: l-arginine (200 mg/kg) had no significant effect on sexual competence (interms of sexual arousal, libido, sexual vigour and sexual performance). In mating experiments, the higher dose of l-arginine effectively and reversibly inhibited fertility, whilst the lower dose and the inactive stereoisomer D-arginine hadno significant effect. The antifertility effect caused by l-arginine was due to a profound elevation in the preimplantationloss mediated possibly by impairment in epididymal sperm maturation, hyperactivated sperm motility and sperm capaci-tation. Conclusion: Elevated NO production may be detrimental to male fertility.

关键词： l-arginine nitric oxide fertility libido sex behavior pre-implantation loss sperm motility contraceptives

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l-arginine administration ameliorates serum and pulmonary cytokine response after gut ischemia-reperfusion in immature rats

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World Journal of Gastroenterology 2005年第7期11卷 1070-1072页

作者： Ting-liangFu Wen-TongZhang lanZhang FengWang YongGao MingXu DepartmentofPediatricSurgery QiluHospitalofShandongUniversityJinan250012ShandongProvinceChina ClinicalNutritionCenterandDepartmentofRadiology AffiliatedHospitalofBinzhouMedicalCollegeBinzhou256603ShandongProvinceChina BinzhouMedicalCollege Binzhou256603ShandongProvinceChina

AIM: Small intestinal ischemia-reperfusion (IR) has been demonstrated to result in both local mucosal injury and systemic injuries. The exact role of nitric oxide (NO) in intestinal IR is unclear. We propose that NO and some other cytokines change in the reperfusion period and these changes are associated with lung injury. The aim of this study was to determine the effect of supplementing NO substrate, l-arginine (l-arg), on serum and pulmonary cytokine production during small intestinal IR in immature rats. METHODS: Immature rats underwent 60 min. of superior mesenteric artery occlusion followed by 90 min of reperfusion. l-arg (250 mg/kg) was given intravenously to the experimental group (IR+l-arg) which received l-arg after 45 min of intestinal ischemia. Serum and lung endothelin-1 (ET-1), NO, malondialdehyde (MDA), and tumor necrosis factor a (TNFα) were measured. Sham operation (SHAM) and intestinal IR (IR) groups were performed as control. The lavage fluid of the lung was collected by bronchoalveolar lavage (BAl) and white blood cells and polymorphonuclear cells (PMNs) were immediately counted to identify lung damage. RESUlTS: When l-arg was given during small intestinal IR, serum NO concentration increased significantly in IR+l-arg group (162.17±42.93 μmol/l) when compared with IR group (87.57±23.17 μmol/l, t=3.190, P= 0.008 ly in IR+l-arg group (8.93±1.50 nmol/l) when compared with SHAM (23.78±7.81 nmol/l, t= 3.243, P= 0.007l/l, t= 3.421, P= 0.006level in lung tissues was significantly lower in IR+l-arg group (13.81±7.84 pg/ml) than that in SHAM (35.52±10.82 pg/ml, t= 2,571, P= 0,03l, t= 3.025, P= 0.009lung tissues were significantly lower in IR+l-arg group (10.73±1.99 nmol/l) than in SHAM (16.62±2.28 nmol/l, t= 3.280, P = 0.007l/l, t= 3.322, P= 0.007lung TNFα concent

关键词： Intestine Ischemia-reperfusion Nitric oxide l-arginine Rat

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Water boosted CO_(2)/C_(2)H_(2)separation in l-arginine functionalized metal–organic framework

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Nano Research 2023年第5期16卷 6113-6119页

作者： Hejin Zhu Wenjuan Xue Hongliang Huang lvyun Chen Haoyu liu Chongli Zhong State Key laboratory of Separation Membranes and Membrane Processes Tiangong UniversityTianjin 300387China Country School of Chemistry and Chemical Engineering Tiangong UniversityTianjin 300387China School of Material Science and Engineering Tiangong UniversityTianjin 300387China

The separation of CO_(2)/C_(2)H_(2)mixture by CO_(2)-selective sorbents is an energy-efficient C_(2)H_(2)purification technique,but is strategically challenging due to their similar molecular size and physicochemical ***,water is inevitable in CO_(2)/C_(2)H_(2)mixture and it is usually a significant barrier because of its competitive adsorption with CO_(2).To address this challenge,herein,we report the first example of metal–organic framework(MOF)that exhibits water-boosted CO_(2)adsorption and CO_(2)/C_(2)H_(2)separation by anchoring l-arginine(ARG)on the Zr6 cluster of *** CO_(2)affinity and capacity in the resulting MOF-808-ARG are markedly facilitated by the presence of water,while the C_(2)H_(2)adsorption is significantly ***,CO_(2)adsorption capacities in adsorption isotherm and breakthrough measurement are increased to 143%and 184%,*** addition,the wet MOF-808-ARG exhibits the record CO_(2)/C_(2)H_(2)selectivity of 1,180 under zero *** experiments reveal that CO_(2)/C_(2)H_(2)mixture can be completely separated and the result of mass spectrometry indicates that the C_(2)H_(2)purity in the outlet is up to 99.9%.In situ infrared(IR)results and density functional theory(DFT)calculations reveal the water-promoted CO_(2)adsorption mechanism that the formation of bicarbonate products in the presence of water is thermodynamically and kinetically more favorable than that without ***,MOF-808-ARG also possesses excellent water stability and excellent regeneration of CO_(2)*** work provides a new paradigm by transforming the negative effects of water into positive ones for CO_(2)/C_(2)H_(2)separation.

关键词： metal–organic frameworks l-arginine moisture acetylene(C_(2)H_(2))purification CO_(2)adsorption

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Diffusion Coefficients of l-arginine in Non-Newtonian Fluid

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Chinese Journal of Chemical Engineering 2008年第6期16卷 856-860页

作者：朱春英马友光季喜燕 School of Chemical Engineering and Technology.State Key laboratory of Cl~emical Engineering Tianjin UniversityTianjin 300072 China

l-arginine is an important component of amino acid injection. Its diffusion in body fluid and blood is of key importance to understand drug diffusion and drug release. As a fundamental demand for study and being a considerably valuable reference for application, in this study, the diffusion coefficients of l-arginine in polyacrylamide（PAM） aqueous solution used as non-Newtonian fluid similar to blood and body fluid were measured using a holographic interferometer. The effects of interaction among molecules and solution concentration on diffusion were analyzed and discussed, respectively. Based on the obstruction-scaling model, a novel modified model was presented for predicting diffusivity of solute in non-Newtonian fluid. Good agreement was achieved between the calculated value and the experimental data.

关键词： l-arginine diffusion coefficient holographic interferometer non-Newtonian fluid obstruction-scaling model

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Effects of multiple intrathecal administration of l-arginine with different doses on formalin-induced nociceptive behavioral responses in rats

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Neuroscience Bulletin 2010年第3期26卷 211-218页

作者：李宽祁文秀山西医科大学太原030001 山西医科大学汾阳学院生理学教研室汾阳032200

Objective To investigate the effects of nitric oxide （NO） with different doses on modulation of inflammatory pain, and its possible *** NO precursor l-arginine （l-Arg） was intrathecally administered in rats at a dose of 10 μg per day （low dose group） or 250μg per day （high dose group） for a succession of 4 *** saline was applied as a *** the rats were subcutaneously injected with formalin （100μl,2%） into the right hindpaw,and the nociceptive behavioral responses within 1 h were *** 4 h after formalin injection,neuronal NO synthase （nNOS） and c-Fos expression in spinal dorsal horn was examined with immunocytochemistry *** The subcutaneous injection of formalin evoked biphasic behaviors of licking or biting the injected *** was no difference in acute phase of formalin test among the 3 groups,while in tonic phase,the licking and biting time,and the protein levels of nNOS and c-Fos in spinal dorsal horn were significantly decreased in low dose group and increased in high dose group,compared with those in control *** These results suggest that multiple administration of NO with different doses may produce different *** one hand,the low dose of NO can induce *** the other hand,the high dose of NO can induce pronociception.

关键词： l-arginine nitric oxide formalin test pain nitric oxide synthase genes c-fos spinal cord

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Protective effects of l-arginine on pulmonary oxidative stress and antioxidant defenses during exhaustive exercise in rats

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Acta Pharmacologica Sinica 2005年第8期26卷 992-999页

作者： Wan-teng lIN~(2,5), Suh-ching YANG~3, Kung-tung CHEN~4, Chi-chang HUANG~3, Ning-yuean lEE~(2,6) ~2 Department of Nutrition and Food Sciences, Fu-Jen Catholic University, Taipei, China ~3 School of Nutrition and Health Sciences, Taipei Medical University, Taipei, China ~4 Department of General Education, Ming Hsin University of Science and Technology Hsinchu, China ~5 De lin Institute of Technology, Taipei, China Department of Nutrition and Food Sciences Fu-Jen Catholic University Taipei China

Aim: To assess the effects of l-arginine (l-Arg) supplementation on pulmonary oxidative stress and antioxidant defenses in rats after exhaustive exercise. Methods: Rats were randomly divided into four groups: sedentary control (SC), sedentary control with l-Arg treatment (SC+Arg), exhaustive exercise with control diet (E) and exhaustive exercise with l-Arg treatment (E+Arg). Rats in groups SC+Arg and E+Arg received a 2% l-Arg diet. Rats in groups E and E+Arg underwent an exhaustive running test on a motorized treadmill. Pulmonary oxidative stress indices [xanthine oxidase (XO), myeloperoxidase (MPO), and malondialdehyde (MDA)] and antioxidant defense systems [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR), and glutathione (GSH)] were investigated in this study. Results: l-Arg supplementation significantly reduced exercise-induced elevations of XO and MPO activities in lung. lArg reversed the exercise-induced increase in SOD and GR activities, but increased CAT and GPX activities. l-Arg administration also significantly increased the GSH levels in plasma. Conclusion: l-Arg supplementation can prevent elevations of XO and MPO activities in the lung and favorably influence pulmonary antioxidant defense systems after exhaustive exercise.

关键词： l-arginine oxidative stress xanthine oxidase myeloperoxidase exhaustive exercise lung

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Dietary rumen-protected l-arginine or N-carbamylglutamate enhances placental amino acid transport and suppresses angiogenesis and steroid anabolism in underfed pregnant ewes

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Animal Nutrition 2023年第4期15卷 149-158页

作者： Hao Zhang Xia Zha Bei Zhang Yi Zheng Xiaoyun liu Mabrouk Elsabagh Yi Ma Hongrong Wang Guihua Shu Mengzhi Wang laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition College of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China Joint International Research laboratory of Agriculture and Agri-Product Safety the Ministry of Education of ChinaYangzhou UniversityYangzhou 225009China Department of Animal Production and Technology Faculty of Agricultural Sciences and TechnologiesNigde Omer Halisdemir UniversityNigde 51240Turkey Department of Nutrition and Clinical Nutrition Faculty of Veterinary MedicineKafrelsheikh UniversityKafrelSheikhEgypt Department of Pediatrics Northern Jiangsu People's HospitalClinical Medical CollegeYangzhou UniversityYangzhou 225001China

This study aimed to investigate the effects of dietary supplementation of underfed Hu ewes from d 35 to110 of gestation with either rumen-protected l-arginine(RP-Arg)or N-carbamylglutamate(NCG)on placental amino acid(AA)transport,angiogenic gene expression,and steroid *** d 35 of gestation,32 Hu ewes carrying twin fetuses were randomly divided into four treatment groups,each consisting of eight ewes,and were fed the following diets:A diet providing 100%of NRC’s nutrient requirements for pregnant ewes(CON);A diet providing 50%of NRC’s nutrient requirements for pregnant ewes(RES);RES diet plus 5 g/d NCG(RES+NCG);or RES diet plus 20 g/d RP-Arg(RES+ARG).On the d 110 of pregnancy,blood samples were taken from the mother,and samples were collected from type A cotyledons(COT;the fetal portions of the placenta).The levels of 17β-estradiol and progesterone in the maternal serum and both the capillary area density(CAD)and capillary surface density(CSD)in type A COT were decreased in response to Arg or NCG supplementation when compared to the RES *** concentrations of arginine,leucine,putrescine and spermidine in type A COT were higher(Plevels of inducible nitric oxide synthase(iNOS)and solute carrier family 15,member 1(SlC15A1)were increased(Ple those of progesterone receptor(PGR)and fibroblast growth factor 2(FGF2)were decreased in type A COT by supplementation with either NCG or RP-Arg compared to the RES *** results suggest that providing underfed pregnant ewes from d 35 to 110 of gestation with a diet supplemented with NCG or RP-Arg improves placental AA transport,and reduces the expression of angiogenic growth factor genes and steroid anabolism,leading to better fetal development.

关键词： Angiogenesis factor l-arginine N-carbamylglutamate Placental amino acid transport Pregnant ewes Steroid anabolism

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Dietary N-carbamylglutamate or l-arginine supplementation improves hepatic energy status and mitochondrial function and inhibits the AMP-activated protein kinase-peroxisome proliferator- activated receptor γ coactivator-1α-transcription factor A pathway in intrauterine-growth-retarded suckling lambs

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Animal Nutrition 2021年第3期7卷 859-867页

作者： Hao Zhang Xiaoyun liu Shengnan Ren Mabrouk Elsabagh Mengzhi Wang Hongrong Wang laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition College of Animal Science and TechnologyYangzhou UniversityYangzhou225009China Joint International Research laboratory of Agriculture and Agri-Product Safety The Ministry of Education of ChinaYangzhou UniversityYangzhou225009China Department of Animal Production and Technologies Faculty of Agricultural Sciences and TechnologiesNigde Omer Halisdemir UniversityCampusNigde51240Turkey Department of Nutrition and Clinical Nutrition Faculty of Veterinary MedicineKafrelsheikh UniversityKafr El-SheikhEgypt

The objective of this study was to investigate the effects of dietary administration of l-arginine(Arg)or N-carbamylglutamate(NCG)on hepatic energy status and mitochondrial functions in suckling Hu lambs with intrauterine growth retardation(IUGR).Forty-eight newborn Hu lambs of 7 d old were allocated into 4 treatment groups of 12 lambs each,in triplicate with 4 lambs per replicate(2 males and 2 females)as follows:CON(lambs of normal birth weight,4.25±0.14 kg),IUGR(3.01±0.12 kg),IUGR+1%Arg(2.99±0.13 kg),or IUGR+0.1%NCG(3.03±0.11 kg).The experiment lasted for 21 d,until d 28 after birth,and all lambs were fed milk replacer as a basal *** with IUGR lambs,NCG or Arg administration increased(Plevel and the activities of com-plexes I/III/IV,isocitrate dehydrogenase and citrate synthase in the *** with CON lambs,the relative mRNA levels of adenosine monophosphate-activated protein kinaseα1(AMPKα1),peroxisome proliferator-activated receptorγcoactivator-1α(PGC1α)and transcription factor A(TFAM)were increased(Pliver of IUGR lambs,but were decreased(Pliver of NCG-or Arg-treated lambs compared with those in the IUGR *** with IUGR lambs,NCG or Arg administration decreased(Pl AMPKα(tAMPKα)-to-phosphorylated AMPKα(pAMPKα)ratio and the protein expression of PGC1αand *** results suggested that dietary Arg or NCG supplements improved hepatic energy status and mitochondrial function and inhibited the AMPK-PGC1α-TFAM pathway in IUGR suckling lambs.

关键词： l-arginine liver Intrauterine growth restriction Energy status Mitochondrial function N-carbamylglutamate

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