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Pharmacodynamic Mechanism of kuanxiong aerosol for Vasodilation and Improvement of Myocardial Ischemia

Chinese Journal of Integrative Medicine 2022年第4期28卷 319-329页

作者： LU Yan YANG Mei-ling SHEN A-ling LIN Shan PENG Mei-zhong WANG Tian-yi LU Zhu-qing WANG Yi-lian PENG Jun CHU Jian-feng Academy of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhou350122China Chen Keji Academic Thought Inheritance Studio Fujian University of Traditional Chinese MedicineFuzhou350122China Fujian Key Laboratory of Integrative Medicine on Geriatrics Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Acupuncture and Moxibustion Third People’s Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou350122China

Objective: To explore the effect of kuanxiong aerosol(KXA)on isoproterenol(ISO)-induced myocardial injury in rat models.Methods: Totally 24 rats were radomly divided into control,ISO,KXA low-dose and high-dose groups according to the randomized block design method,and were administered by intragastric administration for 10 consecutive days,and on the 9th and 10th days,rats were injected with ISO for 2 consecutive days to construct an acute myocardial ischemia model to evaluate the improvement of myocardial ischemia by KXA.In addition,the diastolic effect of KXA on rat thoracic aorta and its regulation of ion channels were tested by in vitro vascular tension test.The influence of KXA on the expression of calcium-CaM-dependent protein kinase Ⅱ(CaMK Ⅱ)/extracellular regulated protein kinases(ERK)signaling pathway has also been tested.Results: KXA significantly reduced the ISO-induced increase in ST-segment,interventricular septal thickness,cardiac mass index and cardiac tissue pathological changes in rats.Moreover,the relaxation of isolated thoracic arterial rings that had been precontracted using norepinephrine(NE)or potassium chloride(KCl)was increased after KXA treatment in an endothelium-independent manner,and was attenuated by preincubation with verapamil,but not with tetraethylammonium chloride,4-aminopyridine,glibenclamide,or barium chloride.KXA pretreatment attenuated vasoconstriction induced by CaCl_(2)in Ca^(2+)-free solutions containing K^(+) or NE.In addition,KXA pretreatment inhibited accumulation of Ca^(2+)in A7r5 cells mediated by KCl and NE and significantly decreased p-CaMK Ⅱ and p-ERK levels.Conclusion: KXA may inhibit influx and release of calcium and activate the CaMK Ⅱ/ERK signaling pathway to produce vasodilatory effects,thereby improving myocardial injury.

关键词： kuanxiong aerosol myocardial ischemia vasodilation Ca^(2+) CaMKⅡ/ERK pathway

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Interim Analysis Report of kuanxiong aerosol in Improving Angina and Quality of Life after Percutaneous Coronary Intervention

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World Journal of Traditional Chinese Medicine 2022年第1期8卷 87-91页

作者： Luo-Qi Lin Bing-Xin Wu Miao-Yang Lin Qiu-Xiong Chen Dan-Ping Xu The Second Clinical Medical College Guangzhou University of Chinese Medicine Department of Cardiology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou Postdoctoral Research Station Institute of Integrative Chinese and Western MedicineFujian University of Traditional Chinese MedicineFuzhouChina

Objective: The objective is to observe the effect of kuanxiong aerosol(KXA) on angina and the quality of life of patients after percutaneous coronary intervention(PCI). Materials and Methods: Six hundred patients with angina after PCI(AAP) were randomly assigned to an experimental group and a control group(n = 300 in each group) and received basic treatment with KXA or basic treatment(respectively) for 8 weeks. The Seattle Angina Questionnaire(SAQ) and visual analog scale(VAS) scores of the two groups during the screening period and five follow-up periods were compared. Results: A total of 179 patients were included in this interim report, including 85 in the experimental group and 94 in the control group. Among the five-dimensional scores of the SAQ, the improvement in the angina frequency and quality of life scores in the experimental group was better than those in the control group after treatment(P 0.01). The difference in VAS scores between the two groups was not statistically significant(P > 0.01). No obvious adverse reactions were observed between the two groups. Conclusions: KXA can reduce the frequency of AAP and improve patients’ quality of life.

关键词： Angina kuanxiong aerosol percutaneous coronary intervention quality of life

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kuanxiong aerosol(宽胸气雾剂)in Treatment of Angina Pectoris:A Literature Review and Network Pharmacology

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Chinese Journal of Integrative Medicine 2021年第6期27卷 470-480页

作者： ZHANG Yu-zhuo ZENG Rui-xiang ZHOU Yuan-shen ZHANG Min-zhou The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou(510120)China Department of Critical Care Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510120)China Division of Chest Pain Center Guangdong Provincial Hospital of Chinese MedicineGuangzhou(510120)China

Angina pectoris(AP)is the most common symptom of cardiovascular diseases,which seriously affects the quality of life in cardiovascular patients.kuanxiong(KX)aerosol(宽胸气雾剂),a compound preparation that consists of 5 traditional Chinese medicines:Herba Asari,Rhizoma Alpiniae Officinarum,Lignum Santali Albi,Fructus Piperis Longi,and Borneolum,has been used in the treatment of AP for many years,exhibiting a significant curative effect and less side-effect.For the convenience and comprehensive understanding of KX aerosol,this review systematically summarizes evidence on KX aerosol in the treatment of AP including the pharmacological effects of its composition,clinical research,animal experiments,and network pharmacology prediction.Meanwhile,we highlight the research limitation of KX aerosol at present.This review may guide the clinical application of KX aerosol and further provide a reference for the research of AP.

关键词： kuanxiong aerosol angina pectoris pharmacology clinical application network pharmacology

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