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Kindler syndrome protein kindlin-1 is mainly expressed in adult tissues originating from ectoderm/endoderm

Science China(Life Sciences) 2015年第5期58卷 432-441页

作者： ZHAN Jun YANG Mei ZHANG Jing GUO YongQing LIU Wei ZHANG HongQuan Key Laboratory of Carcinogenesis and Translational Research Ministry of Education State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science Center Laboratory of Molecular Cell Biology and Tumor Biology Department of Anatomy Histology and Embryology Peking University Health Science Center Department of Thoracic Surgery Sino-Japan Friendship Hospital Department of Immunology Third Military Medical University

Mutations of integrin-interacting protein kindlin-1 cause Kindler syndrome and deregulation of kindlin-1 is implicated in human cancers. The kindlin-1-related diseases are confined in limited tissue types. However, kindlin-1 tissue distribution and the dogma that governs kindlin-1 expression in normal human body are elusive. This study examined kindlin-1 expression in normal human adult organs, human and mouse embryonic organs by immunohistochemical analyses. We identified a general principle that the level of kindlin-1 expression in tissues is tightly correlated with the corresponding germ layers from which these tissues originate. We compared the expression of kindlin-1 with kindlin-2 and found that kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm, whereas kindlin-2 is mainly expressed in mesoderm-derived tissues. Likewise, kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in human and mouse embryos. Our findings indicate that kindlin-1 may play an importance role in the development of endoderm/ectoderm related tissues.

关键词： kindlin- 1 epithelial tissue ectoderm endoderm embryo

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