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The effect of plasma uric acid on oxidative stress in ankylosing spondylitis by keap1-nrf2 signaling pathway

Journal of Hainan Medical University 2020年第10期26卷 47-50页

作者： Rui-Ming Shen Guo-Quan Li Feng Guo Department of Rheumatology The First affiliated hospital of Hainan medical universityHaikou570102China

Objective:To investigate the mechanism of serum uric acid in Ankylosing spondylitis(AS)through the Kelch-like ECH-Associating protein 1(keap1)-nuclear factor erythroid 2 related factor 2(nrf2)signaling ***:A total of 60 AS patients in our hospital from March 2018 to October 2019 were recruited and divided into the active group(>4 points,26 cases)and the inactive group(≤4 points,34 cases)according to the Bath Ankylosing Spondylitis Disease Activity Index(BASDAI).keap1,nrf2,catalase(CAT),superoxide dismutase(SOD),Malondialdehyde(MDA),reactive nitrogen species(RNS),reactive oxygen species(ROS)were detected by ELISA;furthermore,erythrocyte sedimentation rate(ESR),Uric acid(UA)and C-reactive protein(CRP)were *** relationship among UA,BASDAI and oxidative stress indicators were ***:The expression levels of ESR,CRP,UA,ROS,RNS,MDA,and keap1 in the active group were significantly higher than those in the inactive group(all Pnrf2,CAT,and SOD in the active group were higher than those in the inactive group,markedly reduced(all Pkeap1 were notably positively correlated with blood UA and BASDAI in the active group with AS patients;while nrf2,CAT,and SOD were negatively correlated with blood UA and ***,blood UA and BASDAI were found to be moderately positively ***:The results in the study demonstrate that the UA level in blood is related to the AS disease activity,blood UA exerts the pro-inflammatory effects,increasing oxidative stress injury and reducing antioxidant capacity,possibly by activating the keap1-nrf2 pathway.

关键词： Ankylosing spondylitis Serum uric acid Oxidative stress keap1-nrf2 pathway

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Regulating Signal pathway Triggers Circular Reactive Oxygen Species Production to Augment Oxidative Stress with Enzyme-Activated Nanoparticles

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CCS Chemistry 2024年第3期6卷 693-708页

作者： Benkai Bao Qiong Yuan Qian Feng Ling Li Meiqi Li Yanli Tang Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid ChemistryMinistry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’anShaanxi Province 710119

Regulating antioxidative stress pathways to augment oxidative stress and enhance antitumor therapy is highly desirable but very ***,we initiated a multifunctional nanoparticle to regulate the keap1-nrf2 antioxidative stress pathway to promote cancer cell *** OPFV-SnMP@GE11 nanoparticles were assembled by enzyme-activated OPFV-TLQ,tin mesoporphyrin(SnMP),and ***-SnMP@GE11 accumulated at tumor sites through specific targeting with ***-TLQ was specifically reduced to a photosensitizer OPFVNH2 by endocellular NAD(P)H:quinone oxidoreductase 1(NQO1).Under irradiation,OPFV-NH2 greatly produced reactive oxygen species(ROS)through a type I mechanism,which activated the keap1-nrf2 signal pathway and enhanced the transcription of NQO1,resulting in a continuous and explosive generation of ***,SnMP inhibited the activity of heme oxygenase-1(HO-1),further depressing antioxidative *** strategy provides insight into the regulation of the signal pathway to amplify oxidative stress,paving the way to studying the molecular mechanisms of cellular activities to enhance cancer therapy.

关键词： keap1-nrf2 pathway enzyme-activated probe reactive oxygen species oxidative stress antitumor therapy

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