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World Journal of Pediatrics 2017年第1期13卷 20-26页

作者： Min-Zhong Zhang Peng-Cheng Xun Ka He Wei Cai Department of Pediatric Surgery Xinhua hospitalShanghai Jiao Tong University School of MedicineNo.1665Kongjiang RoadShanghaiChina Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition No.1665Kongjiang RoadShanghaiChina Department of Epidemiology and Biostatistics School of Public Health-BloomingtonIndiana University1025 E.Seventh StreetBloomingtonINUSA

Background:It is controversial whether adjuvant steroid treatment should be given to biliary atresia rBAl patients following a kasai portoenterostomy(KPE).This study aimed to quantitatively and systematically evaluate... 详细信息

关键词： biliary atresia kasai portoenterostomy steroid treatment

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基于kasai的安全管理系统

制造业自动化 2011年第1期33卷 187-189,201页

作者：陈红梅商丘师范学院计算机科学系商丘476000

kasai是一个开源100%基于Java的认证与授权框架。它提供一个完善的,易于管理的许可方案来与你应用程序相结合的。这个框架的目的是为多用户应用程序提供一个使用简单但强大的安全环境。kasai具有较高级别的安全抽象,接口更加通用;它的... 详细信息

kasai是一个开源100%基于Java的认证与授权框架。它提供一个完善的,易于管理的许可方案来与你应用程序相结合的。这个框架的目的是为多用户应用程序提供一个使用简单但强大的安全环境。kasai具有较高级别的安全抽象,接口更加通用;它的目标在于特定的安全需求。本系统是基于kasai的安全管理系统,采用J2EE架构,使用struts2+hibernate开源框架来实现的。

关键词： J2EE Struts2框架 Hibernate框架 Oracle数据库 kasai

kasai肝门肠吻合术:肝脏组织学上的新认识

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世界核心医学期刊文摘（儿科学分册） 2005年第7期1卷 37-38页

作者： Hussein A. Wyatt J. Guthrie A. Stringer M.D. 宁亮 Department of Histopathology Children's Liver Unit St.James's University Hospital Leeds LS9 7TF United Kingdom

Background/Purpose: The aim of this paper was to investigate the mechanism of long-term biliary drainage after kasai portoenterostomy by clinicopathologic study of hepatic morphology in explanted ***: Explanted livers from 13 consecutive children undergoing transplantation for biliary atresia were examined in detail using a standardized *** 1 (n = 6) had no kasai procedure before transplantation at a median age of 8 *** 2 (n = 4) were transplanted at a median age of 10 m after a failed kasai *** 3 (n = 3) had a successful kasai but required transplantation for complications of chronic liver disease at 12-14 *** findings were correlated with hepatic morphology determined by pretransplant magnetic resonance ***: Large perihilar regenerative nodules (8-14 cm diameter) were observed in 2 patients after successful kasai portoenterostomy, less well-de-fined perihilar nodules in group 2 patients, and no regenerative nodules in group ***, group 1 had diffuse biliary cirrhosis with evidence of progressive ductopenia during *** group 2, perihilar regenerative nodules showed variable portal fibrosis but no cirrhosis and bile ducts were present with 68%-100%of hepatic arteries; in peripheral cirrhotic areas, bile ducts were absent in patients older than 9 *** perihilar regenerative nodules in group 3 patients had a noncirrhotic architecture with preserved bile ducts, but the peripheral parenchyma was cirrhotic; one patient had diffuse macronodular *** morphologic findings correlated well with magnetic resonance images, highlighting the preservation of relatively normal perihilar liver architecture after successful kasai ***: Unoperated biliary atresia is associated with progressive intrahepatic ductopenia leading to diffuse biliary *** portoenterostomy can result in the growth of large perihilar regenerative nodules, probably as a conseque

关键词：肝门肠吻合术 kasai 肝脏组织学胆管闭锁肝门肠吻合手术再生结节大结节性肝硬化慢性肝脏疾病移植术胆汁性肝硬化

冈果民主共和国(前扎伊尔)东kasai的人类猴痘

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疾病监测 1998年第10期 39-41页

背景：人类猴痘象天花一样，在临床上具有严重的系统性出疹，它是由猴痘病毒（ＭＰＶ）引起的罕见散发性人兽共患病，是正痘病毒在哺乳动物中引起的地方性动物病，包括栖息在非洲中西部热带雨林地区的猴子和松鼠。１９９６年７月和８月... 详细信息

背景：人类猴痘象天花一样，在临床上具有严重的系统性出疹，它是由猴痘病毒（ＭＰＶ）引起的罕见散发性人兽共患病，是正痘病毒在哺乳动物中引起的地方性动物病，包括栖息在非洲中西部热带雨林地区的猴子和松鼠。１９９６年７月和８月份，在Ｋａｔａｋｏ－Ｋｏｍｂｅ健康...

关键词：人类猴痘 kasai 扎伊尔刚果(金,利) 继发病猴痘病毒

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葛西(kasai)式手术及其有关问题

河北医科大学学报 1983年第1期15卷 68-70页

作者：李振东河北医学院附属二院外科

胆道闭锁是婴儿胆道疾病中最常见的一种,大约每两万个新生儿中即有1例。根据其病变情况,大略可分为可矫治型(5～20％)和不可矫治型(80～95％)两类。前者经手术建立胆道与肠道的连续后,多可得到良好的结果;后者大多数将在生后19个月内死... 详细信息

胆道闭锁是婴儿胆道疾病中最常见的一种,大约每两万个新生儿中即有1例。根据其病变情况,大略可分为可矫治型(5～20％)和不可矫治型(80～95％)两类。前者经手术建立胆道与肠道的连续后,多可得到良好的结果;后者大多数将在生后19个月内死亡。因此,多年来外科医生多方探求不可矫治型胆道闭锁的治疗方法。曾试用:①造成肝外胆瘘后再转入消化道;②用Soufhey氏管多方向插入肝脏,造成肝消化道瘘;③切除部分肝脏,行肝、消化道吻合;

关键词：胆管炎纤维胆囊胆管疾病胆道肠吻合术 kasai 手术肝门胆道闭锁门脉高血压门脉高压症

胆管闭锁行kasai肝门肠吻合术后的迟发性胆管炎和Roux环梗阻

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世界核心医学期刊文摘（儿科学分册） 2006年第11期2卷 48-49页

作者： Houben C. Phelan S. Davenport M. 刘凯 The Department of Paediatric Surgery King's College HospitalSE5 9RS London United Kingdom

Background/Purpose: Late-onset cholangitis is an uncommon complication after the kasai operation for biliary *** with 3 recent patients illustrates appropriate ***: Retrospective review of patients with late unexplained deterioration in liver function attributed to *** underwent quantitative radioisotope hepatobiliary scans to identify the Roux loop obstruction and confirm post operative resolution. The role of percutaneous transhepatic cholangiography and computed tomography scanning was ***: Three patients aged 8, 13, and 17 years were identified. All 3 had had a successful kasai portoenterostomy for type 3 biliary atresia and presented after several virtually trouble-free years with late-onset cholangitis. The radioisotope scans in all 3 patients showed poor tracer uptake by the liver and pooling of the radioisotope at the porta hepatis. Laparotomy confirmed a proximal Roux loop obstruction at the level of the mesocolic window in all. This required mobilization and adhesiolysis and, in 1, correction of an actual stenosis with in the wall of the intestine at this level. All patients had normalization of their liver function postoperatively. All are now well and anicteric at a follow-up of 6 to 12 months. Conclusions:Long-term survivors of the kasai portoenterostomy for biliaryatresia with immediate deterioration in liver function warrant investigation for possible Roux loop obstruction. Resolution of the obstruction allows preservation of their native liver.

关键词：肝门肠吻合术 kasai Roux 胆管闭锁救治经验粘连松解术胆管造影术小肠壁肝胆管扫描

奥曲肽治疗kasai肝肠吻合术后的顽固性乳糜性腹水

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 52-53页

作者： Hwang J. -B. Choi S. -O. Park W. -H. 宁亮 Depts. of Pediat. Sugery and Pediat. Keimyung Univ. Dongsan Med. Center Daegu South KoreaDr.

Chylous ascites is a rare disorder with variables causes. Herein, the authors report a case of refractory chylous ascites after kasai operation for biliary at resia, whichwas treated successfully with subcutaneous octreotide, a synthetic s omatostatin analogue. To the best of the authors’knowledge, this is the first r eport in the English-language literature of post-kasai chylous ascites being s uccessfully treated with subcutaneous octreotide in parallel with the continuati on of enteral feeding.

关键词：肝肠吻合术 kasai 乳糜性腹水奥曲肽首例报道生长抑素类似物胆道闭锁持续肠内营养英文文献

抗菌药物使用对kasai术后胆管炎多重耐药菌定植的影响分析

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实用器官移植电子杂志 2023年第1期11卷 29-32页

作者：张平平郭艳婷齐继初玉芹王烨天津市第一中心医院儿科天津300192

目的分析kasai术后患儿肠道定植菌的耐药情况及抗菌药物使用对多重耐药菌(multidrug resistant organisms,MDROs)定植的影响,以期为kasai术后胆管炎患儿MDROs定植的预防和治疗提供参考依据。方法收集2021年1月至2022年6月天津市第一中... 详细信息

目的分析kasai术后患儿肠道定植菌的耐药情况及抗菌药物使用对多重耐药菌(multidrug resistant organisms,MDROs)定植的影响,以期为kasai术后胆管炎患儿MDROs定植的预防和治疗提供参考依据。方法收集2021年1月至2022年6月天津市第一中心医院收治的kasai术后胆管炎病例,根据患儿入院时的MDROs定植情况将患儿分为病例组(定植)和对照组(无定植),比较两组患儿的一般情况、kasai术时日龄、胆道闭锁分型、既往胆管炎次数与既往静脉抗菌药物使用情况。结果共纳入64例患儿,MDROs组43例,非MDROs组21例。从直肠拭子中检出致病菌76株,肺炎克雷伯杆菌最多(37例,耐碳青霉烯类33例),其次为屎肠球菌(12例,耐万古霉素1例)、大肠埃希菌(11例,耐碳青霉烯类4例)。两组患儿一般情况、kasai术时日龄、胆道闭锁分型、既往胆管炎次数无统计学差异;MDROs组碳青霉烯类抗菌药物使用率高于非MDROs组,分别为53.5%和33.3%(P=0.129),MDROs组广谱抗菌药物使用率高于非MDROs组,分别为39.5%和19.0%(P=0.101),MDROs组2种以上抗菌药物联合静脉应用率高于非MDROs组,分别为51.2%和19.0%(P=0.014)。结论两种以上抗菌药物联合应用可能会导致MDROs的定植,从而因肠道细菌移位引起MDROs的血流感染和胆道感染。因此应采取有效防治措施,合理应用抗菌药物,减少kasai术后患儿MDROs的发生。

关键词： kasai 胆管炎多重耐药菌定植

Reduction of the ages at diagnosis and operation of biliary atresia in Taiwan: A 15-year population-based cohort study

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World Journal of Gastroenterology 2015年第46期21卷 13080-13086页

作者： Jen-Shyang Lin Solomon Chih-Cheng Chen Chin-Li Lu Hung-Chang Lee Chun-Yan Yeung Wai-Tao Chan Department of Pediatrics Ditmanson Medical Foundation Chia-Yi Christian Hospital Department of Pediatric Gastroenterology Mac Kay Children’s Hospital Department of Pediatrics School of MedicineTaipei Medical University Department of Public Health College of MedicineNational Cheng Kung University

AIM: To describe the ages at diagnosis and operation of biliary atresia(BA) and its incidence over a 15-year period in ***: This was a population-based cohort study. BA cases were identified from the Taiwan National Health Insurance Research Database based on the International Classification of Diseases,Ninth Revision(ICD-9) code of BA 751.61 plus kasai operation(ICD-9 procedure code 51.37) or liver transplantation(LT,ICD-9 procedure code 50.5). The patients' characteristics including sex,age at diagnosis,age at receiving kasai operation and age at receiving LT were compared among three birth cohorts:(1) 1997 to 2001;(2) 2002 to 2006; and(3) 2007 to ***: There were a total of 540 BA cases(275 females) with an incidence of 1.62 per 10000 live births. No seasonality of BA was noted. The mean ages at diagnosis of three cohorts were 57.9,55.6 and 52.6 d.A linear regression model demonstrated a decreasing trend of the mean age at diagnosis(1.27 d per year). The proportion of BA cases that received the kasai operation within 60 d of age increased from 76% to 81%. A total of 189(35%) BA patients underwent LT. The mean age at LT was reduced from 3-year-old to 1-year-old. The rates of LT were 25.6% and 32.3% in patients who received the kasai operation within 60 d or after 60 d of age,respectively. All patients who did not undergo a kasai operation eventually required ***: The ages at diagnosis and operation in BA cases have decreased over time. kasai operation performed at younger age reduces the need for LT. The incidence of BA in Taiwan fluctuates,but without certain trend.

关键词： Age Biliary atresia kasai operation Stool color ca

Liver transplantation for biliary atresia: A single-center study from China's Mainland

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World Journal of Gastroenterology 2015年第32期21卷 9638-9647页

作者： Qi-Gen Li Ping Wan Jian-Jun Zhang Qi-Min Chen Xiao-Song Chen Long-Zhi Han Qiang Xia Department of Liver Surgery Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Department of Pediatric Surgery Shanghai Children’s Medical Center School of Medicine Shanghai Jiao Tong University

AIM: To summarize our single-center experience with liver transplantation(LT) for biliary atresia(BA).METHODS: From October 2006 to December 2012, 188 children with BA were analyzed retrospectively. The stage?Ⅰ?group(from October 2006 to December 2010) comprised the first 74 patients, and the stage Ⅱ group(from January 2011 to December 2012) comprised the remaining 114 patients. Finally, 123 liver transplants were performed in 122(64.9%) patients, whereas 66 patients did not undergo LT due to denial by their parents or lack of suitable liver grafts. The selection of graft types depended on the patients' clinical status and whether a suitable living donor was available. The characteristics of patients in stages?Ⅰ?and Ⅱ were described, and the surgical outcomes of LT recipients were compared between the two stages. The KaplanMeier method was used to estimate the cumulative patient and graft survival rates, and the equality of survival distributions was evaluated using the log-rank ***: The 188 children consisted of 102 boysand 86 girls. Their ages ranged from 3 to 144 mo with a median of 8 mo. One hundred and fifteen(61.2%) patients were born in rural areas. Comparing stage?Ⅰ?and stage Ⅱ patients, the proportion of patients referred by pediatricians(43.2% vs 71.1%, respectively; P kasai procedure(KP)(32.4% vs 44.7%, respectively; P = 0.092) obviously increased, and significantly more parents were willing to treat their children with LT(73% vs 86%, respectively; P = 0.027). Grafts from living donors(102/122, 83.6%) were the most commonly used graft type. Surgical complications(16/25, 64.0%) were the main reason for posttransplant mortality. Among the living donor liver transplantation recipients(n = 102), the incidence of surgical complications was significantly reduced(34.1% vs 15.5%, respectively; P = 0.029) and survival rates of patients and grafts were greatly improved(81.8% vs 89.7%, respec

关键词： Biliary atresia Liver transplantation kasai Living