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New insights into effects of kaixin powder on depression via lipid metabolism related adiponectin signaling pathway

Chinese Herbal Medicines 2023年第2期15卷 240-250页

作者： Wenshan Yang Hong Yin Yichen Wang Yuanbo Wang Xia Li Chaochen Wang Ping Liu Yuan Hu Department of Pharmacy Medical Supplies Center of PLA General HospitalChinese PLA General HospitalBeijing 100853China Pharmacy Care Center Medical Supplies Center of PLA General HospitalChinese PLA General HospitalBeijing 100853China Chinese PLA Medical School Chinese PLA General HospitalBeijing 100853China Department of Outpatient Group 82 Military HospitalBaoding 071000China

Objective:To clarify the anti-depressive potential mechanisms of kaixin powder(KP),a drug that helps to prevent and treat depression and other mentaldiseases,from genome-wide transcriptome ***:Transcriptome and KEGG pathway analysis were conducted on the hippocampus of depressed rats,then the differentially expressed genes were validated and serum concentration of lipid parameters were identified by enzymatic ***,high-fat diets induced depression-like behaviors in Syrian golden hamsters were conducted to verify the predicted molecular mechanisms acquired from the transcriptome ***:Transcriptome results revealed that the 24 differentially expressed genes(DEGs)in chronic mild stress(CMS)rats could be reversed after two weeks of KP *** mechanisms of KP in treating depression firstly involved the regulation of several pathology modules,including lipid metabolism,synapse function and *** could regulate imbalances of lipid homeostasis in high-fat diet induced depressive ***,it was validated that cholesterol metabolism dysfunction can be ameliorated by KP,which was correlated with upregulation of the AdipoR1-BDNF(brainderived neurotrophic factor)co-regulatory ***:Taken together,our results demonstrated that KP not only alleviates depression via traditional mental illness targets,but it may also simulates the cholesterol metabolism and adiponectin signaling with multi-target characteristics.

关键词： adiponectin cholesterol homeostasis depression high-fat diet kaixin powder transcriptome analysis

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Effects of kaixin powder(开心散)on Melatonin Receptor Expression and ^(125)I-Mel Binding Affinity in A Rat Model of Depression

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Chinese Journal of Integrative Medicine 2015年第7期21卷 507-515页

作者：黄妍丽梁雪冰钱丽旗蔡川郭军高超关健华赵国平 Department of Traditional Chinese Medicine Jinan University Department of Traditional Chinese Medicine First Attilicated Hospital of the Chinese People's Liberation Army

Objective： To explore the effects of kaixin powder （开心散, KXP） on melatonin receptor （MR） expression and 1261-Mel binding affinity in a depression rat model. Methods： Seventy-two male Wistar rats were divided into six groups： a blank control group, model group, ramelteon group, KXP high-dosage group （HKXP）, medium-dosage group （MKXP） and low-dosage group （LKXP）. To establish the depression model, all groups except the blank control group were singly housed and exposed to chronic unpredictable mild stress. Weight gain, sucrose consumption and the open-field test were used to evaluate induction of depression. KXP at 260, 130 and 65 mg/（kg·d） was also respectively administered to the rats in the HKXP, MKXP and LKXP groups for 21 days. Ramelteon [0.83 mg/（kg·d）] was given to the positive drug control group. An equivalent volume of physiological saline was given to the blank and model groups. The liquid chip method was used to measure the concentration of plasma melatonin （MT）. Mell a （MT1） and Mellb （MT2） expression levels were determined by Western blotting. In addition, a radioactive ligand-binding assay was used to analyze the specific binding properties and dynamic characteristics between MR and 125I-Mel. Results： The results of weight gain, sucrose consumption and the open-field test showed that our model successfully produced depressive symptoms and depressive-like behavior. The concentration of plasma MT in the model group decreased significantly at night but increased in the MKXP group （P〈0.05）. The HKXP group showed significantly increased expression of MT1 （P〈0.05）; however, the expression of MT2 in all groups exhibited no significant differences （P〉0.05）. The maximum binding capacity （Bmax） for specific binding between MR and 125I-Mel in the MKXP group was significantly higher than that in the model group （P〈0.05）, but no significant differences were found in the equilibrium dissociation constant （Kd） of each group （P〉0.05）. Conclusions： KXP may have a similar

关键词： depression melatonin receptor 125I-Mel melatonin kaixin powder Chinese medicine

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The treatment effects of kaixin powder on depression through heart-spleen axis

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Drug Combination Therapy 2021年第3期3卷 26-31页

作者： Hui-Mei Shi Xin Li Jia-Lin Wu Di Zhang Guo-Ping Zhao Jinan University College of Traditional Chinese medicineGuangzhou 510632China

Depression is a kind of mental disorder characterized by conspicuous and persistent low mood, sustained sadness, loss of interest and forgetfulness. In traditional Chinese medicine, heart (different from the concept in Western medicine) control the emotions. Overthinking hinders the function of the spleen. Deficiency of spleen leads to lack of heart-Qi. Deficiency of the spleen also leads to dysfunction of heart. Once the heart is dysfunction, Qi will be stagnated in Danzhong(thoracic center), eventually leads to depression. In Traditional Chinese medicine, the development of depression is a heart-spleen-heart process, which can be called the "heart-spleen axis". Biomedicine studies have found that the progress of depression is mainly caused by long-term adverse stimulation of the central nervous system, which affects the Hypothalamic-pituitary-adrenal axis (HPA) to convey monoamine neurotransmitters, such as 5- hydroxytryptamine (5-HT), and further damaged the intestinal mucosal barrier, increased its permeability, and produced a large number of lipopolysaccharides (LPS) and inflammatory factors. The production of LPS and inflammatory cytokines reduces the synthesis of 5-HT by consuming tryptophan, and the decrease of 5-HT in serum results in the decrease of 5-HT levels in the brain. At the same time, changes in the intestinal microbiota alter the concentration of brain-derived neurotrophic factor (BDNF) via the vagal pathway, ultimately creating a vicious brain-gut- brain cycle. kaixin powder has the effect of invigorating spleen and eliminating dampness, awaking consciousness and inducing resuscitation, and can adjust the imbalance of gut microbiota and neurotransmitters to achieve the purpose of treating depression.

关键词： Depression Brain-gut axis Heart-Spleen axis kaixin powder Gut microbiota

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