检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

LVMH欲收购平价美妆品牌KIko

品质 2024年第4期 7-7页

近日,LVMH控股的私募股权投资公司L Catterton正在与意大利知名彩妆品牌KIko MILANO(简称“KIko”)所有者Percassi家族进行独家谈判,拟收购其部分股份。KIko是由父子企业家Antonio和Stefano Percassi于1997年在意大利创立的彩妆品牌。... 详细信息

近日,LVMH控股的私募股权投资公司L Catterton正在与意大利知名彩妆品牌KIko MILANO(简称“KIko”)所有者Percassi家族进行独家谈判,拟收购其部分股份。KIko是由父子企业家Antonio和Stefano Percassi于1997年在意大利创立的彩妆品牌。凭借产品的多样性和卓越的性价比,KIko迅速成为意大利销量第一的彩妆品牌,被誉为“彩妆性价比之王”。

关键词：彩妆私募股权投资性价比 KI ko

Novel translational rat models of dopamine transporter deficiency

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第12期13卷 2091-2093页

作者： Damiana Leo Ilya Sukhanov Raul R.Gainetdinov Department of Neurosciences University of Mons Institute of Pharmacology Pavlov Medical University Institute of Translational Biomedicine St. Petersburg State University

Dopamine （DA） is one of the brain＇s fundamental neurotransmitters. Despite the fact that the dopaminergic synapses constitute less than 1% of all brain synapses, DA is implicated in a number of critical physiological functions and in the pathogenesis of important psychiatric diseases such as schizophrenia, attention-deficit/hyperactivity disorder （ADHD）, Parkinson＇s disease （PD） and others.

关键词： DAT ko Novel translational rat models of dopamine transporter deficiency

High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes

在线全文

学校读者我要写书评

暂无评论

Bone Research 2014年第3期2卷 152-181页

作者： Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel Lexicon Pharmaceuticals The Woodlands TX USA

Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening （HTS） data for 3 762 distinct global gene knockout （ko） mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type （WT） cagemates/littermates were examined for each gene ko. Lethality was observed in an additional 850 ko lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from ko lines with intriguing HTS bone data were examined. Aging, ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass： 23 previously reported genes （Calcr, Cebpb, Crtap, Dcstamp, Dkkl, Duoxa2, Enppl, Fgf23, Kissl/Kisslr, Kl （Klotho）, Lrp5, Mstn, Neol, Npr2, Ostml, Postn, Sfrp4, S1c30a5, Sic39a13, Sost, Sumf1, Src, Wnt10b）, five novel genes extensively characterized （Cldn18, Fam20c, Lrrkl, Sgpll, Wnt16）, five novel genes with preliminary characterization （Agpat2, RassfS, Slc10a7, Stc26a7, Slc30a10） and three novel undisclosed genes coding for potential osteoporosis drug targets.

关键词： ko High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes BMD HTS DEXA gene

Targeted knockout of duox causes defects in zebrafish growth, thyroid development, and social interaction

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2019年第2期46卷 101-104页

作者： Jong-Su Park Tae-Ik Choi Oc-Hee Kim Ted Inpyo Hong Woo-Keun Kim Won-Jae Lee Cheol-Hee Kim Department of Biology Chungnam National University Biosystem Research Group Korea Institute of Toxicology School of Biological Sciences Seoul National University

Reactive oxygen species(ROS) are believed to be inevitable and toxic by-products produced during cellular respiration. However,several lines of evidence show that diverse extracellular signals can activate ROS product... 详细信息

关键词： ko In Targeted knockout of duox causes defects in zebrafish growth thyroid development and social interaction

Macaque monkeys as a non-human primate circadian model

在线全文

学校读者我要写书评

暂无评论

National Science Review 2019年第2期6卷 302-303页

作者： Han Wang Center for Circadian Clocks Soochow University NSR

Circadian studies have become one of the prestigious fields in biology, as evidenced by the award of 2017 Nobel Prize in Physiology or Medicine to three pioneers in this field [1]. Even though this Nobel Prize honored the discovery of the molecular genetic basis underlying the fascinating time-keeping mechanisms of living things, it indeed underscored the far-reaching medical implications of the

关键词： Macaque monkeys as a non-human primate circadian model ko

Instability of microsatellites linked to targeted genes inCRISPR/Cas9-edited and traditional gene knockout mouse strains

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2018年第10期45卷 553-556页

作者： Xueyun Huo Xiulin Zhang Yihan Liu Yizhu Sun Yu Ren Changlong Li Xiaoyan Du Zhenw en Chen School of Basic Medical Sciences Capital Medical UniversiryBeijing Key Laboratory of Cancer Invasion&Metastasis ResearchBeijing 100069China

The classic method for gene knockout (ko) is based on homologous recombination (HR) and embryonic stem cell technique (Gerlai,1996).Actually,the procedure of homologous replacement is complicated and time consuming,although it has been popular during the past decades.Recent years,genome editing which can cause DNA sequence-specific mutations in the genomes of cellular

关键词： MSI ko Instability of microsatellites linked to targeted genes in CRISPR/Cas9-edited and traditional gene knockout mouse strains

“中国最强中学生” 18岁拳手张沛勉造就ko战斗力

在线全文

学校读者我要写书评

暂无评论

健与美 2022年第5期 50-53页

作者：沈诚不详

他,小学第一场比赛58秒ko获胜,12岁获得广西北海市首届博海杯30公斤级冠军;13岁斩获三项搏击对抗赛冠军;14岁ko了20岁成年拳手,获得“中国最强中学生”称号;18岁走上国际赛场,4次击倒ISKA世界冠军,一战成名,他就是绰号“战斗鸡”的张沛勉。

关键词：广西北海市国际赛场对抗赛世界冠军中学生 ko 战斗力公斤级

在线全文

学校读者我要写书评

暂无评论

koE与流量私有化

中国服饰 2022年第5期 26-27页

作者：陈禹安合抱科技

抖音最近开展了一系列动作,只为给关键意见员工(Key Opinion Employee,简称为"koE")的兴起提供更好的平台土壤。随着抖音电商日渐成熟,其对商品交易总额(GMV)的要求也有了更高的要求。由此,抖音需要更多的账号对粉丝拥有更强大的黏性与... 详细信息

抖音最近开展了一系列动作,只为给关键意见员工(Key Opinion Employee,简称为"koE")的兴起提供更好的平台土壤。随着抖音电商日渐成熟,其对商品交易总额(GMV)的要求也有了更高的要求。由此,抖音需要更多的账号对粉丝拥有更强大的黏性与消费号召力。这就要求抖音完成从公域流量到私域流量的转变。

关键词：私有化商品交易电商号召力 ko

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

koE的“冲突策略”

中国服饰 2022年第12期 V0024-V0025页

作者：陈禹安不详

在此前的文章中,我们介绍过故事容器的“1+1=1”思维,即将想要推广的产品信息和账号的主体内容合二为一。但无论是koL(Key Opinion Leader,关键意见领袖)、koC(Key Opinion Consumer,关键意见消费者)还是koE(Key Opinion Employee,关键... 详细信息

在此前的文章中,我们介绍过故事容器的“1+1=1”思维,即将想要推广的产品信息和账号的主体内容合二为一。但无论是koL(Key Opinion Leader,关键意见领袖)、koC(Key Opinion Consumer,关键意见消费者)还是koE(Key Opinion Employee,关键意见员工),本质上都是故事讲述者,正是在他们的自我叙事中,账号(IP)及其影响力被塑造、强化、升华。

关键词：关键意见领袖自我叙事合二为一 ko 主体内容账号