检索结果-南通市图书馆

检索条件"主题词=KCTD13"

共 1 条记录，以下是1-10 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Population Genomic Insights into High Altitude Adaptation in Pamirs

Population Genomic Insights into High Altitude Adaptation in...

引用

2018中国遗传学会第十次全国会员代表大会暨学术讨论会

作者： Xierzhatijiang Sulaiman Min-Sheng Peng Wei-fang Xu Jin-Xiu Li Najmudinov Tojiddin Abdulloevich Manilova Elena Afanasevna Khudoidodov Behruz Ibrohimovich Xi Chen Wei-Kang Yang Xing-Yan Yang Quan-Kuan Shen Shi-Fang Wu Yun Gao Newton O.Otecko Yong-Gang Yao Lu-Feng Cheng Ya-Ping Zhang Department of Pharmacology College of PharmacyXinjiang Medical University State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences Kunming College of Life Science University of Chinese Academy of Sciences KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Shenzhen Hospital of Guangzhou University of Chinese Medicine State Key Laboratory for Conservation and Utilization of Bio-Resources Yunnan University E.N.Pavlovsky Institute of Zoology and Parasitology Academy of Sciences of Republic of Tajikistan Research Center for Ecology and Environment of Central Asia Chinese Academy of Sciences Key Laboratory of Biogeography and Bioresource in Arid Land Xinjiang Institute of Ecology and GeographyChinese Academy of Sciences Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

Tajik highlanders have resided in Pamirs（altitude ＞3000 m） for thousands of years. How they adapted to the harsh conditions remains unsolved. Herein, we measured four physiological traits for two groups of Tajik highlanders: Sarikoli Tajik and Wakhi Tajik, in comparison to highland Kyrgyz. Neither hematologic nor spirometric evidence exhibit Tibetan-style adaptation in Tajik highlanders. To discern the potential genetic mechanism of high altitude adaptation in Tajik highlanders, we sequenced the whole genomes of 19 Sarikoli Tajiks, 20 Wakhi Tajiks, and 20 lowland Tajiks. The population genomic analyses reveal Tajiks as a branch of Central Asians experiencing complicated patterns of gene flows from European, South Asian, and East Asian populations. The settlement of Pamirs by the Sarikoli Tajiks is approximated to be around 3200 years ago. Selective sweep assessments, verified by coalescent simulation, identify SNRNP40, ZCCHC17, and FABP3 on chromosome 1, and kctd13, TMEM219, and TAOK2 on chromosome 16, as the potential targets of selection in the Sarikoli Tajiks. These genes are involved in neurological development and diseases. The selective haplotypes in the Sarikoli Tajiks are standing variations with distribution in lowland populations. Luciferase reporter assays show that the selective haplotype of kctd13 promoter and enhancer regions exhibit higher transcription activity than the nonselective haplotype. Overall, our findings provide novel insight into a very recent high altitude adaptation in humans, which probably targeted nervous system by utilizing standing variations via soft sweep.

关键词： High altitude adaptation Tajiks Pamirs nervous system kctd13

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共1页 << < 1 > >>

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：