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Current Perspectives on Histone Demethylases

Acta Biochimica et Biophysica Sinica 2007年第2期39卷 81-88页

作者： Xiaoqing TIAN and Jingyuan FANG Shanghai Jiaotong University School of Medicine,Renji Hospital,shanghai Instituteof Digestive Disease,Shanghai 200001,China Shanghai Jiaotong University School of Medicine Renji Hospital Shanghai Institute of Digestive DiseaseShanghai 200001 China

The posttranslational modification of histones plays an important role in chromatin regulation.Histone methylation influences constitutive heterochromatin,genomic imprinting,X-chromosome inactivationand gene transcription.Histone demethylase catalyzes the removal of methyl groups on lysine or arginineresidues of histones.Two kinds of histone lysine demethylases have been identified, including lysine specificdemethylase 1 and jumonji C (JmjC) domain family proteins.These histone demethylases are involved in theregulation of gene expression.Histone modification is a dynamic process,and the imbalance of histonemethylation has been linked to cancers.Therefore,histone demethylases may represent a new target foranti-cancer therapy.

关键词： epigenetic modification histone methylation demethylase lysine specific demethylase 1 jumonji C(JmjC)protein

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Vitamin D, Testosterone, Epigenetics and Pain an Evolving Concept of Neurosignaling, Neuroplasticity and Homeostasis

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World Journal of Neuroscience 2018年第2期8卷 203-253页

作者： Joseph Thomas Pierre Morris Eric Seigel Wayne State University/Ascension Crittenton Detroit USA

The thought of exploring a possible relationship between the broad systems of steroid hormone physiology (specifically vitamin D and testosterone) and nocioception was prompted by an unexpectedly frequent personal clinical observation. Patients with chronic pain syndromes or chronic musculoskeletal pain often have low serum levels of vitamin D and testos-terone. Mining for relevant information in Pub Med, Medline and Cochrane Systems Review, three concepts repeatedly emerge that provide a common context for understanding the mechanics of these diverse sys-tems—epigenetic, homeostasis and neuroplasticity. Viewing homeostasis within the framework of epigenetics allows reasoned speculation as to how various human systems interact to maintain integrity and function, while simultaneously responding in a plastic manner to external stimuli. Cell signaling supports normal function by regulating synaptic activity, but can also effect plastic change in the central and peripheral nervous system. This is most commonly achieved by post-translational remodeling of chromatin. There is thus persistent epigenetic change in protein synthesis with all the related downstream effects but without disruption of normal DNA se-quencing. In itself, this may be considered an example of genomic homeo-stasis. Epigenetic mechanisms in nociception and analgesia are active in the paleospinothalamic and neospinothalamic tracts at all levels. Physiologic response to a nociceptive insult, whether mechanical, inflammatory or ischemic, is provided by cell signaling that is significantly enhanced through epigenetic mechanisms at work in nociceptors, Gamma-Aminobutyric Acid (GABA) and glutamate receptors, voltage gated receptors, higher order neurons in the various dorsal horn laminae and proximal nociceptive pro-cessing centers in the brainstem and cortex. The mediators of these direct or epigenetic effects are various ligands also active in signaling, such as free radicals, substance P, a variety of cytokines, growth factors and G proteins, stress r

关键词： Gamma-Aminobutyric Acid (GABA) jumonji (Jmjd3) Homer Gene Cholecalciferol Calcitriol Neurosteroids Glutamate 5-HT

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含JmjC结构域的组蛋白去甲基化酶和调控细胞G1／S期转换的基因之间的关系在癌症发病机制中的作用

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国际呼吸杂志 2012年第8期32卷 624-627页

作者：马丹赵洪文中国医科大学附属第一医院呼吸疾病研究所沈阳110015 中国医科大学附属第四医院呼吸内科沈阳110032

含有jumonjiC结构域的组蛋白去甲基化酶（JHDM）可调控多种基因的转录，影响细胞周期进程，参与癌症发生。本文就JHDM和调控细胞由DNA合成前期向DNA合成期转换的基因的关系作一综述。

关键词： jumonji C结构域组蛋白去甲基化酶细胞周期 G1/S期转换

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