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Characteristic chemical profile of juhe fang extract with lipid-lowering properties

Journal of Traditional Chinese Medical Sciences 2020年第3期7卷 233-244页

作者： Jing Kong Lulu Liu Yuanyuan Gao Siyu Chen Linfu Li Yisong Shu Daohan Sun Yanyan Jiang Renbing Shi School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China Medical College Gannan Medical UniversityGanzhou341000China Chinese Medicine New Drug Preparation R&D Center Beijing Institute of Clinical PharmacyBeijing100035China

Objective:The objective of this study was to verify the lipid-lowering effect of juhe fang extract(JHFE)and to determine its characteristic chemical profile in vitro and in ***:A hyperlipidemia model was established by feeding mice a high-fat diet(HFD).After treatment for 30 days,serum total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)levels were measured with an automatic biochemistry *** components from JHFE obtained from in vivo and in vitro experiments were investigated using an UPLC-Q Exactive-Orbitrap MS/***:The TC,TG,and LDL-C in the serum significantly decreased and the HDL-C significantly increased after JHFE treatment.A total of 95 compounds from JHEF including 15 phenolic acids(PA),4 phenylethanoid glycosides(PG),24 flavonoids(F),14 triterpenoids(T),10 diterpenoid glycosides(D),18 alkaloids(A)and 10 others(O)were *** was discovered for the first time in a herbal medicine of juhe ***,68 compounds were identified in vivo including 28 prototype compounds and 40 *** metabolic characteristics of these components were revealed including identification of new metabolites of 4-hydroxyphenyl ethyl-8-O-[a-L-arabinopyranosyl-(1/6)]-b-D-glucopyranoside(PEG)and lirinidine.A total of 43 components from JHFE were absorbed and/or *** contribution rate of each type of chemical component from JHFE to its lipidlowering effect from high to low were A,F,PG,PA,D and ***:The results of this study showed that JHFE demonstrated a significant lipid-lowering effect in a high-fat diet(HFD)-induced hyperlipidemia mouse *** types of PA,PG,F,D,T and A formed the pharmaceutical architecture of the lipid-lowering effect of *** study should prove useful for clarifying the components responsible for the lipid-lowering effect of JHFE and provide a basis for precision quality control research.

关键词： juhe fang Lipid-lowering effect UPLC-Q exactive-orbitrap MS/MS Chemical characteristic profile Pharmaceutical architecture

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