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Independent and joint association of physical activity and sedentary behavior on all-cause mortality

Chinese Medical Journal 2021年第23期134卷 2857-2864页

作者： Wei Zhou Wei Yan Tao Wang Ling-Juan Zhu Yan Xu Jun Zhao Ling-Ling Yu Hui-Hui Bao Xiao-Shu Cheng Center for Prevention and Treatment of Cardiovascular Diseases The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center NanchangJiangxi 330006China Chronic Disease Prevention and Control Institute Jiangxi Province Center for Disease Control and PreventionNanchangJiangxi 330006China Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China.

Backgrounds:Physical activity(PA)and sedentary behavior(SB)have been associated with mortality,while the joint association with mortality is rarely reported among Chinese *** aimed to examine the independent and joint association of PA and SB with all-cause mortality in southern ***:A cohort of 12,608 China Hypertension Survey participants aged≥35 years were enrolled in 2013 to 2014,with a follow-up period of 5.4 *** self-reported PA and SB were collected via the ***–Meier curves(log-rank test)and Cox proportional hazards regression were performed to evaluate the associations of PA and SB on all-cause ***:A total of 11,744 eligible participants were included in the *** an average of 5.4 years of follow-up,796 deaths *** risk of all-cause mortality was lower among participants with high PA than those with low to moderate level(5.2%vs.8.9%;hazards ratio[HR]:0.75,95%confidence interval[CI]:0.61–0.87).Participants with SB≥6 h had a higher risk of all-cause mortality than those with SBjoint association with the risk of all-cause *** with inadequate PA and prolonged SB had the highest risk of all-cause mortality compared with others.

关键词： Physical activity Sedentary behavior All-cause mortality joint association

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association between Long-Term Exposure to PM_(2.5) Inorganic Chemical Compositions and Cardiopulmonary Mortality: A 22-Year Cohort Study in Northern China

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Environment & Health 2024年第8期2卷 530-540页

作者： Hongyue Sun Xi Chen Wenzhong Huang Jing Wei Xueli Yang Anqi Shan Liwen Zhang Honglu Zhang Jiayu He Chengjie Pan Jingjing Li Jing Wu Tong Wang Jie Chen Yuming Guo Shilu Tong Guanghui Dong Nai-Jun Tang Department of Occupational and Environmental Health School of Public HealthTianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Environment Nutrition and Public Health Tianjin Medical UniversityTianjin 300070China Center for International Collaborative Research on Environment Nutrition and Public Health Tianjin 300070China Key Laboratory of Prevention and Control of Major Diseases in the Population Ministry of EducationTianjin Medical UniversityTianjin 300070China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Department of Atmospheric and Oceanic Science Earth System Science Interdisciplinary CenterUniversity of MarylandCollege ParkMaryland 20740United States Shandong Provincial Hospital Affiliated to Shandong First Medical University Ji nan 250021ShandongChina National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China Department of Epidemiology and Biostatistics School of Public HealthTianjin Medical UniversityTianjin 300070China School of Public Health Shanxi Medical UniversityTaiyuan 030001China School of Public Health and Social Work Queensland University of TechnologyBrisbane 4072QLD Australia National Institute of Environmental Health Chinese Centre for Disease Control and PreventionBeijing 100021China Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment Department of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China

Particulate matter with diameters≤2.5μm(PM_(2.5))has been identified as a significant air pollutant contributing to premature ***,the specific compositions within PM_(2.5) that play the most crucial role remain unclear,especially in areas with high pollution *** study aims to investigate the individual and joint mortality risks associated with PM_(2.5) inorganic chemical compositions and identify primary *** 1998,we conducted a prospective cohort study in four northern Chinese cities(Tianjin,Shenyang,Taiyuan,and Rizhao).Satellite-based machine learning models calculated PM_(2.5) inorganic chemical compositions,including sulfate(SO_(4)^(2–)),nitrate(NO_(3)^(–)),ammonium(NH_(4)^(+)),and chloride(Cl^(-)).A time-varying Cox proportional hazards model was applied to analyze associations between these compositions and cardiorespiratory mortality,encompassing nonaccidental causes,cardiovascular diseases(CVDs),nonmalignant respiratory diseases(RDs),and lung *** quantile-based g-computation model evaluated joint exposure effects and relative contributions of the *** analysis was used to identify vulnerable *** 785,807 person-years of follow-up,5812(15.5%)deaths occurred from nonaccidental causes,including 2932(7.8%)from all CVDs,479(1.3%)from nonmalignant RDs,and 552(1.4%)from lung *** interquartile range(IQR)increase in SO_(4)^(2–)was associated with mortality from nonaccidental causes(hazard ratio:1.860;95%confidence interval:1.809,1.911),CVDs(1.909;1.836,1.985),nonmalignant RDs(2.178;1.975,2.403),and lung cancer(1.773;1.624,1.937).In the joint exposure model,a simultaneous rise of one IQR in all four compositions increased the risk of cardiorespiratory mortality by at least 36.3%,with long-term exposure to SO_(4)^(2–)contributing the most to nonaccidental and cardiopulmonary *** with higher incomes and lower education levels were found to be more vulnerable.

关键词： PM_(2.5)inorganic chemical compositions mortality cohort study cardiorespiratory disease joint association

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