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A pharmacological approach to study the active compounds in jinshui Huanxian formula in treatment of pulmonary fibrosis

引用

Journal of Traditional Chinese Medicine 2019年第3期39卷 364-379页

作者： Bai Yunping Zhao Peng Wu Mingming Li Jiansheng Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province Henan University of Chinese MedicineZhengzhou 450046 China Henan Key Laboratory of Chinese Medicine for Respiratory Disease Henan University of Chinese Medicine Zhengzhou 450046 China

OBJECTIVE:To study the active compounds in jinshui Huanxian formula in the treatment of pulmonary fibrosis with a pharmacological ***:A systems pharmacology model,incorporating active compounds and targets prediction,and herbal-comPound-target-disease network analysis,was established to predict the active substances and therapeutic mechanisms of jinshui Huanxian *** compounds from the herbs of jinshui Huanxian formula were obtained from drug database and the ***,we analyzed the potential of herbs by predicting oral bioavailability and drug-likeness *** compounds with oral bioavailability≥ 30% and drug-likeness index ≥ 0.18 were obtained as candidate compounds for further *** then used the systematic drug targeting tool to screen the targets for candidate *** potential targets were projected into Therapeutic Target Database to collect their corresponding *** candidate compounds,potential targets and their related diseases were applied to construct the compound-target and target-disease ***:Totally 136 compounds from jinshui Huanxian formula and 265 potential targets were ***-target network analysis suggested that different herbal drugs contained in the jinshui Huanxian formula could regulate these similar targets to probably exert synergistic ***,target proteins were mainly related to oxidoreductase activity,nicotinamide adenine dinucleotide phosphate binding,and G-protein coupled amine receptor activity,which might be associated with the therapeutic mechanisms of jinshui Huanxian *** addition,jinshui Huanxian formula was probably efficient for many different diseases,such as respiratory tract diseases,neoplasm,nervous system diseases,and cardiovascular diseases,according to target-disease ***:This study may provide a method to explore the potential active compounds in jinshui Huanxian formula used to treat pulmonary fibrosis.

关键词： Pulmonary fibrosis Pharmacology jinshui Huanxian formula

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