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Comparative study on the anti-tuberculous effect and mechanism of the traditional Chinese medicines NiuBeiXiao He extract and jiehewan

引用

Military Medical Research 2022年第2期9卷 164-183页

作者： Li-Yao Duan Yan Liang Wen-Ping Gong Yong Xue Jie Mi Jie Wang Lan Wang Zai-Xing Jia Hong Lei Yu-Mei Liang Jun Liu Yue Zheng Xue-Qiong Wu Tuberculosis Prevention and Control Key Laboratory Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and TreatmentTuberculosis Research Institutethe 8th Medical CenterChinese PLA General HospitalBeijing 100091China Hebei North University Zhangjiakou 075000HebeiChina Clinical Laboratory the 8th Medical CenterChinese PLA General HospitalBeijing 100091China Pathology Department the 8th Medical CenterChinese PLA General HospitalBeijing 100091China Guangdong Qifang Pharmaceutical Co. LtdGuangzhou 510075China

Background:The traditional Chinese medicine NiuBeiXiaoHe(NBXH)extract and Chinese medicine preparation jiehewan(JHW)exhibit anti-tuberculosis(TB)*** anti-TB effect of NBXH was compared with that of JHW to elucidate the mechanism of action of ***:BALB/c mice aged 6-8 weeks were randomly divided into a normal control group,TB model group,JHW treatment group,and NBXH treatment *** 3 and 13 weeks of treatment,the therapeutic effect in each group was evaluated by comparing lung histopathology,lung and liver colony counts,the number of spots representing effector T cells secreting IFN-γin an enzyme-linked immunospot assay(ELISPOT),and the levels of Th1,Th2,and Th17 cytokines,which were measured by a cytometric bead array(CBA).Mouse RNA samples were subjected to transcriptome ***:After 13 weeks of treatment,the mean histopathological lesion area of the NBXH group was significantly smaller than that of the TB model group(P<0.05).Compared with those in the TB model group,the lung colony counts in the JHW and NBXH groups were significantly decreased(P<0.05),and the IL-2 and IL-4 levels in the NBXH group were significantly increased(P<0.05).NBXH partly restored significant changes in gene expression caused by Mycobacterium tuberculosis(***)*** to GO and KEGG analyses,the changes in biological process(BP),cell composition(CC)and molecular function(MF)terms and in signaling pathways caused by NBXH and JHW treatment were not completely consistent,but they were mainly related to the immune response and inflammatory response in the mouse TB ***:NBXH had therapeutic effects similar to those of JHW in improving lung histopathology,reducing lung colony counts,and regulating the levels of *** restored significant changes in gene expression and repaired cell damage caused by *** infection by regulating immune-related pathways,which clarified the mechanism of action of NBXH.

关键词： Traditional Chinese medicine Tuberculosis NiuBeiXiaoHe extract jiehewan Therapeutic effect

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