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A network pharmacology analysis on jiawei buhuanjin zhengqi powder against COVID-19 in children

Precision Medicine Research 2021年第1期3卷 31-44页

作者： Jing Lai Liang-Yi Qin Zhe Tang Qi Zhang Pharmacy Department of 923rd Hospital of PLA Nanning 530021China Traditional Chinese Medcine Department of 923rd Hospital of PLA Nanning 530021China.

Background:To clarify the effectiveness and potential mechanism of jiawei buhuanjin zhengqi powder(JBZP)for the prevention and treatment of coronavirus disease 2019(COVID-19)in children based on network ***:The active ingredients and action targets of jiawei buhuanjin zhengqi powder formulas were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis *** related to COVID-19 were found on the GeneCards *** active ingredients-target network map was constructed by *** action mechanisms of these genes were predicted using a Gene Ontology-based functional enrichment and annotation tool and the Kyoto Encyclopedia of Genes and ***:Through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,187 eligible compounds and 12,921 targets of jiawei buhuanjin zhengqi powder were identified.A total of 257 genes related to jiawei buhuanjin zhengqi powder and 401 genes related to COVID-19 in children were screened and 59 common target genes were *** network analysis showed that the predicted seven main active components were Quercetin,Luteolin,Wogonin,Kaempferol,Irisolidone,Nobiletin and Licochalcone *** Ontology and the Kyoto Encyclopedia of Genes and Genomes enrichment analysis revealed that key targets were associated with regulating immunological function or glycosylation through the biological ***:The potential mechanisms of jiawei buhuanjin zhengqi powder on COVID-19 in children might be related to anti-inflammatory,virus infection,and immunomodulatory signaling pathway.

关键词： Novel coronavirus COVID-19 Traditional Chinese medicines Network pharmacology jiawei buhuanjin zhengqi powder Children

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