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jianpi qingchang bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss

引用

World Journal of Gastroenterology 2022年第13期28卷 1315-1328页

作者： Ya-Li Zhang Qian Chen Lie Zheng Zi-Wei Zhang Yu-Jun Chen Yan-Cheng Dai Zhi-Peng Tang Institute of Digestive Diseases LongHua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Gastroenterology Traditional Chinese Medicine Hospital of Shaanxi ProvinceXi’an 710003Shaanxi ProvinceChina Department of Gastroenterology Shanghai Traditional Chinese Medicine-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China

BACKGROUND Bone loss and osteoporosis are commonly described as extra-intestinal manifestations of inflammatory bowel disease(IBD).jianpi qingchang bushen decoction(JQBD)is a prescription used in clinical ***,further studies are needed to determine whether JQBD regulates the receptor activator of nuclear factor kappa B(NF-κB)(RANK)/receptor activator of NF-κB ligand(RANKL)/osteoprotegerin(OPG)pathways and could play a role in treating IBD-induced bone *** To evaluate the therapeutic effect of JQBD in IBD-induced bone loss and explore the underlying *** An IBD-induced bone loss model was constructed by feeding 126-to-8-wk-old interleukin-10(IL-10)-knockout mice with piroxicam for 10 *** mice were randomly divided into model and JQBD *** used wild-type mice as a *** JQBD group was administered the JQBD suspension for 2 wk by gavage,while the control and model groups were given normal saline at the corresponding time *** mice were killed after the *** effect of JQBD on body weight,disease activity index(DAI),and colon length was *** examination,colon ultrastructure observation,and micro-computed tomographic scanning of the lumbar vertebrae were *** gene expression of NF-κB,tumor necrosis factor-α(TNF-α),IL-1β,IL-6,and IL-8 in the colon was evaluated by real-time polymerase chain *** samples were assessed by Western blot for the expression of RANKL,OPG,RANK,and NF-κB *** The model group lost body weight,had a shorter colon,and showed a dramatic increase in DAI score,whereas JQBD had protective and therapeutic *** with JQBD significantly improved inflammatory cell infiltration and reduced crypt abscess and ulcer *** imaging of the vertebral centrum in the model group revealed a lower bone mass,loose trabeculae,and“rod-shaped”changes in the structure compared to the control group and JQBD *** bone volume/

关键词： Inflammatory bowel disease Osteoporosis jianpi qingchang bushen decoction Inflammation Bone metabolism

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