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Network pharmacology-based exploration of molecular mechanisms underlying therapeutic effects of jianpi huatan quyu recipe on chronic heart failure with spleen Qi deficiency syndrome

引用

World Journal of Cardiology 2024年第7期16卷 422-435页

作者： Si-Qi Li Dong-Yu Min Jun-Wen Jiang Xiao-Ying Li Xu-Na Yang Wen-Bo Gu Jia-Hui Jiang Li-Hao Chen Han Nan Ze-Yu Chen Second Department of Cardiology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina

BACKGROUND Chronic heart failure is a complex clinical *** Chinese herbal compound preparation jianpi huatan quyu recipe has been used to treat chronic heart failure;however,the underlying molecular mechanism is still not *** To identify the effective active ingredients of jianpi huatan quyu recipe and explore its molecular mechanism in the treatment of chronic heart *** The effective active ingredients of eight herbs composing jianpi huatan quyu recipe were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis *** target genes of chronic heart failure were searched in the Genecards *** target proteins of active ingredients were mapped to chronic heart failure target genes to obtain the common drugdisease targets,which were then used to construct a key chemical componenttarget network using Cytoscape 3.7.2 *** protein-protein interaction network was constructed using the String *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed through the Metascape ***,our previously published relevant articles were searched to verify the results obtained via network *** A total of 227 effective active ingredients for jianpi huatan quyu recipe were identified,of which quercetin,kaempferol,7-methoxy-2-methyl isoflavone,formononetin,and isorhamnetin may be key active ingredients and involved in the therapeutic effects of TCM by acting on STAT3,MAPK3,AKT1,JUN,MAPK1,TP53,TNF,HSP90AA1,p65,MAPK8,MAPK14,IL6,EGFR,EDN1,FOS,and other *** pathways identified by KEGG enrichment analysis include pathways in cancer,IL-17 signaling pathway,PI3K-Akt signaling pathway,HIF-1 signaling pathway,calcium signaling pathway,cAMP signaling pathway,NF-kappaB signaling pathway,AMPK signaling pathway,*** studies on jianpi huatan quyu recipe suggested that this Chinese compound preparation can regulate the TNF-α,IL-6,MAPK

关键词： jianpi huatan quyu recipe Traditional Chinese medicine Chronic heart failure Data mining Network pharmacology Bioinformatics Spleen Qi deficiency syndrome

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