检索结果-南通市图书馆

World Journal of Neuroscience 2013年第2期3卷 126-130页

作者： Basilio Vagner Ramirez Viviana Castano Palacio Medicarte Multiple Sclerosis ProgramMedellinColombia Pablo Tobon Uribe Hospital MedellinColombia

Proportional to the growth rate of its clinical expression, the last decades have seen an increase on jc virus diagnosis testing, and on therapeutic and symptoms management plans. Whether isolated or associated to retroviral therapy, the relationship of jc virus to HIV allowed us to delve a little deeper into the knowledge of its behavior. Now as new immune-modulating and immune-suppressing therapies are developed, its clinical expression has become broader and more complexly, thereby our need is to develop more precise diagnosis and therapeutic plans.

关键词： jc virus PLM HIV Monoclonal Antibodies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The oncogenic roles of jc virus T antigen in hepatocellular and pancreatic cancers

The oncogenic roles of JC virus T antigen in hepatocellular ...

引用

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青...

作者： Xing Yue Huachuan Zheng The Affiliated Hospital of Chengde Medical University

Aim: There appear spontaneous hepatocellular carcinoma and pancreatic cancer in transgenic mice expressing jc virus（jcV） T antigen. The study aimed to clarify the oncogenic roles of T antigen in human hepatocellular and pancreatic cancers.Methods: Specimens of hepatocellular and pancreatic cancers, and corresponding normal tissues were examined for T antigen of jcV by either nested-or real-time PCR. jcV existence was morphologically detected targeting T antigen by immunohistochemistry and in situ PCR. T antigen expression was also analyzed by Western blot using frozen samples.Results: According to general PCR, the positive rate of T-antigen was lower in hepatocellular carcinoma than adjacent non-tumor tissue（79.0% vs 84.7%, P＜0.05）. It was the same for pancreatic cancer（76.0% vs 92.3%, P＜0.05）. In situ PCR demonstrated that positive cells were detectable in hepatocellular and pancreatic carcinoma cells, hepatocytes, and pancreatic ductal epithelial cells. A strong nuclear immunoreactivity against T antigen was observed in the nucleus of hepatocellular and pancreatic cancers, but not in hepatocytes and pancreatic ducts. A stronger T antigen expression was seen in hepatocellular and pancreatic cancers than paired normal tissues by Western blot.Conclusions: The genomic insertion of T antigen preferred to occur in normal pancreatic and liver tissue in comparison with corresponding cancers. Its protein expression might play an important role in its carcinogenesis.

关键词： jc virus T antigen oncogenesis hepatocellular carcinoma pancreatic cancer

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Pontocerebellar Progressive Multifocal Leukoencephalopathy. Radiological, Clinical, Histological and Immunohistochemical Findings in a Hematological Patient

引用

Open Journal of Pathology 2023年第4期13卷 177-183页

作者： Javier Ortiz Juan Carlos Paniagua Isidro Cavaco Raquel Rivas Andrea Jimenez Luis Chinchilla Elisa Muñoz María Dolores Ludeña Departamento de Biología Celular y Patología Universidad de Salamanca (USAL) Salamanca Spain Servicio de Anatomía Patológica Hospital Universitario de Salamanca Salamanca Spain Servicio de Radiodiagnóstico Hospital Universitario de Salamanca Salamanca Spain

Objective: To describe the radiological, histological and immunohistochemical findings in a case of Progressive Multifocal Leukoencephalopathy (PML) affecting the cerebellar peduncles in a patient with chronic lymphocytic leukemia. Patient and Methods: Magnetic Resonance Imaging (MRI), histological picture (H.E., Kluver-Barrera) and immunohistochemical picture (GFAP, neurofilaments, CD68, jc virus) were obtained. Results: 1) Magnetic resonance imaging: Asymmetric and progressive lesions on middle cerebellar peduncles, that were hyperintense in T2/FLAIR, extended towards the pons, had no mass effect and were unmodified after intravenous contrast. 2) Histology: Marked reactive gliosis with cytopathic changes suggesting viral infection, plus demyelination areas with axonal preservation. 3) Immunohistochemistry: Marked positivity for viral (polyoma and jc virus) markers in glial cells showing cytopathic changes. Conclusions: The importance of histological and immunohistochemical diagnosis in everyday assistance;of the collaboration between clinicians, radiologists and pathologists;and the validity of postmortem studies as a key element for research and clinical quality assessment must be stressed.

关键词： Progressive Multifocal Leukoencephalopathy jc virus Immunohistochemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progressive Multifocal Leukoencephalopathy—A Case Report in an Immunocompetent Patient

引用

Advances in Infectious Diseases 2018年第1期8卷 10-16页

作者： Ana Faceira Daniela Magalhaes Filipa Ceia Joao Nuak Carina Reis Susana Ferreira Internal Medicine Department Hospital de Sao JoaoPortoPortugal Faculdade de Medicina da Universidade do Porto PortoPortugal Endocrinology Diabetes and Metabolism DepartmentHospital de Sao JoaoPortoPortugal Instituto de Investigacao e Inovacao em Saude Universidade do PortoPortoPortugal Infectious Diseases Department Hospital de Sao JoaoPortoPortugal Neuroradiology Department Hospital de Sao JoaoPortoPortugal

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system due to the reactivation of the jc virus, which usually occurs in immunocompromised patients and is a major opportunistic infection associated with HIV infection. We report a case of a previously healthy patient who was diagnosed with PML.

关键词： Immunosuppression Immunocompetent jc virus Progressive Multifocal Leukoencephalopathy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：