检索结果-南通市图书馆

jak inhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes

引用

Acta Pharmaceutica Sinica B 2023年第10期13卷 4185-4201页

作者： Shuai Shao Chengjuan Chen Gaona Shi Yu Zhou Yazi Wei Lei Wu Lan Sun Tiantai Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Monocytes are key effectors in autoimmunity-related diseases in the central nervous system(CNS)due to the critical roles of these cells in the production of proinflammatory cytokines,differentiation of T-helper(Th)cells,and antigen *** jak-STAT signaling is crucial for initiating monocytes induced immune responses by relaying cytokines ***,the role of this pathway in modulating the communication between monocytes and Th cells in the pathogenesis of multiple sclerosis(MS)is ***,we show that the jak1/2/3 and STAT1/3/5/6 subtypes involved in the demyelination mediated by the differentiation of pathological Th1 and Th17 and the CNS-infiltrating inflammatory monocytes in experimental autoimmune encephalomyelitis(EAE),a model for *** inhibition prevented the CNS-infiltrating CCR2-dependent Ly6^(Chi)monocytes and monocyte-derived dendritic cells in EAE *** parallel,the proportion of GM-CSF^(+)CD4^(+)T cells and GM-CSF secretion were decreased in pathological Th17 cells by jak inhibition,which in turns converted CNS-invading monocytes into antigen-presenting cells to mediate tissue ***,our data highlight the therapeutic potential of jak inhibition in treating EAE by blocking the GM-CSF-driven inflammatory signature of monocytes.

关键词： Monocytes T-helper cells Monocyte-derived dendritic cells GM-CSF jak-STAT signaling jak inhibitor Experimental autoimmune encephalomyelitis Multiple sclerosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New insights into the pathogenesis and management of rheumatoid arthritis

引用

Chronic Diseases and Translational Medicine 2022年第4期8卷 256-263页

作者： Shangyi Jin Jiuliang Zhao Mengtao Li Xiaofeng Zeng Department of Rheumatology and Clinical Immunology Chinese Academy of Medical Sciences&Peking Union Medical CollegeNational Clinical Research Center for Dermatologic and Immunologic Diseases(NCRC-DID)Ministry of Science&TechnologyState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College Hospital(PUMCH)Key Laboratory of Rheumatology and Clinical ImmunologyMinistry of EducationBeijingChina

Over the past few decades, understanding of the pathogenesis of rheumatoid arthritis (RA) has improved substantially. Insights into the cellular and molecular mechanisms involved in RA have enabled the discovery of new therapeutic targets and led to the development of biologics and targeted synthetic disease-modifying antirheumatic drugs. In parallel with the improvement in therapies, the evolution of strategies in the management of RA has also contributed considerably to better outcomes in patients. Major changes include the development of disease activity measures, formulation of the treat-to-target principles as well as increased attention to comorbidities. The presence of comorbidities such as cardiovascular diseases may increase the mortality of RA patients, affect their treatment strategies and result in worse outcomes. Therefore, prevention and management of certain high-risk comorbidities have become increasingly important in the long-term treatment of RA. In this study, we summarized new insights into the pathogenesis and management of rheumatoid arthritis and associated comorbidities, with a special focus on the 2021 update of the American College of Rheumatology (ACR) guideline for RA and key reports presented at the 2021 ACR convergence.

关键词： comorbidity drug safety jak inhibitor rheumatoid arthritis single-cell sequencing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Risk of hepatitis B reactivation in patients with myeloproliferative neoplasms treated with ruxolitinib

引用

World Journal of Hepatology 2023年第11期15卷 1188-1195页

作者： Adeniyi Abraham Adesola Matei-Alexandru Cozma Yong-Feng Chen Bahadar Singh Srichawla Mihnea-Alexandru Găman Department of Medicine and Surgery Faculty of Clinical SciencesCollege of MedicineUniversity of IbadanIbadanNigeria Faculty of Medicine "Carol Davila"University of Medicine and PharmacyBucharest 050474Romania Department of Gastroenterology Colentina Clinical HospitalBucharest 020125Romania Department of Basic Medical Sciences Medical College of Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina Department of Neurology University of Massachusetts Chan Medical SchoolWorcesterMA 01655United States Department of Hematology Center of Hematology and Bone Marrow TransplantationFundeni Clinical InstituteBucharest 022328Romania Cellular and Molecular Pathology Department Stefan S.Nicolau Institute of VirologyRomanian AcademyBucharest 030304Romania

Classical Philadelphia-negative myeloproliferative neoplasms(MPNs),i.e.,polycythemia vera,essential thrombocythemia,and primary/secondary myelofibrosis,are clonal disorders of the hematopoietic stem cell in which an uncontrolled proliferation of terminally differentiated myeloid cells *** are characterized by mutations in driver genes,the jak2V617F point mutation being the most commonly detected genetic alteration in these hematological ***,jak inhibition has emerged as a potential therapeutic strategy in MPNs,with ruxolitinib being the first jak inhibitor developed,approved,and prescribed in the management of these blood ***,the use of ruxolitinib has been associated with a potential risk of infection,including opportunistic infections and reactivation of hepatitis ***,we briefly describe the association between ruxolitinib treatment in MPNs and hepatitis B reactivation.

关键词： Ruxolitinib Myeloproliferative neoplasms Hepatitis B Polycythemia vera Myelofibrosis jak inhibitor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Update on biologic therapies for juvenile idiopathic arthritis-associated uveitis

引用

Annals of Eye Science 2021年第2期6卷 78-88页

作者： Joanne Thomas Sanjana Kuthyar Jessica G.Shantha Sheila T.Angeles-Han Steven Yeh Medical College of Georgia AugustaGAUSA Emory Eye Center Emory University School of MedicineAtlantaGAUSA Division of Rheumatology Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA

Juvenile idiopathic arthritis(JIA)is the most common rheumatic disease of childhood,and juvenile idiopathic associated uveitis(JIA-U)is the most frequently noted extra-articular ***-U can present asymptomatically and lead to ocular complications,so regular screening and monitoring are needed to prevent potentially sight-threatening *** glucocorticoids such as prednisolone acetate are usually the first line of treatment for anterior uveitis associated with JIA-U,but long-term use may be associated with cataract,ocular hypertension and *** modifying anti-rheumatic drugs(DMARDs)such as methotrexate allow tapering of the corticosteroids to prevent long-term *** therapies have been increasingly used as targeted therapies for JIA-U,particularly monoclonal antibodies targeting the proinflammatory cytokine TNF-αsuch as adalimumab and *** recent,multicenter,prospective,randomized clinical trial provided evidence of the efficacy of adalimumab with methotrexate for JIA-U compared to methotrexate *** clinical trial studying the interleukin-6 inhibitor tocilizumab for JIA-U showed promise in tapering topical ***,jak inhibitors are emerging biologic therapies for JIA-U in patients refractory to TNF-αinhibitors,with a clinical trial assessing the efficacy of baricitinib for JIA-U *** clinical trials on these novel biologics are limited,further investigation of these agents may provide additional therapeutic options for JIA-U.

关键词： Juvenile idiopathic arthritis(JIA) uveitis biologics tumor necrosis factor alpha uveitis pediatric uveitis jak inhibitor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：