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itopride for gastric volume,gastric emptying and drinking capacity in functional dyspepsia

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第1期8卷 74-80页

作者： Shahab Abid Wasim Jafri Maseeh Uz Zaman Rakhshanda Bilal Safia Awan Aamir Abbas Department of Medicine Aga Khan University Department of Radiology Aga Khan University Pakistan Atomic Energy Commission

AIMTo study the effect of itopride on gastric accommodation, gastric emptying and drinking capacity in functional dyspepsia (FD). METHODSRandomized controlled trial was conducted to check the effect of itopride on gastric accommodation, gastric emptying, capacity of tolerating nutrient liquid and symptoms of FD. We recruited a total of 31 patients having FD on the basis of ROME III criteria. After randomization, itopride was received by 15 patients while 16 patients received placebo. Gastric accommodation was determined using Gastric Scintigraphy. 13C labeled octanoic breadth test was performed to assess gastric emptying. Capacity of tolerating nutrient liquid drink was checked using satiety drinking capacity test. The intervention group comprised of 150 mg itopride. Patients in both arms were followed for 4 wk. RESULTSMean age of the recruited participant 33 years (SD = 7.6) and most of the recruited individuals, i.e., 21 (67.7%) were males. We found that there was no effect of itopride on gastric accommodation as measured at different in volumes in the itopride and control group with the empty stomach (P = 0.14), at 20 min (P = 0.38), 30 min (P = 0.30), 40 min (P = 0.43), 50 min (P = 0.50), 60 min (P = 0.81), 90 min (P = 0.25) and 120 min (P = 0.67). Gastric emptying done on a sub sample (n = 11) showed no significant difference (P = 0.58) between itopride and placebo group. There was no significant improvement in the capacity to tolerate liquid in the itopride group as compared to placebo (P = 0.51). Similarly there was no significant improvement of symptoms as assessed through a composite symptom score (P = 0.74). The change in QT interval in itopride group was not significantly different from placebo (0.10). CONCLUSIONOur study found no effect of itopride on gastric accommodation, gastric emptying and maximum tolerated volume in patients with FD.

关键词： itopride Gastric emptying Gastric accommodation Functional dyspepsia Dyspepsia

Efficacy of itopride in the Prevention of Lubiprostone-Induced Nausea

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Open Journal of Gastroenterology 2014年第9期4卷 305-309页

作者： Tatsuya Abe Yoshikazu Hachiro Yoshiaki Ebisawa Houhei Hishiyama Masanori Murakami Masao Kunimoto Department of Gastroenterology Kunimoto Hospital Asahikawa Japan Department of Proctology Kunimoto Hospital Asahikawa Japan

Background: The efficacy of lubiprostone for chronic constipation has been established through phase III clinical trials. Nevertheless, the continuation of lubiprostone therapy is reportedly difficult due to the development of nausea. The objective of this study is to determine whether the administration of itopride hydrochloride can reduce lubiprostone-related nausea. Methods: Two hundred and thirty-five patients who were receiving lubiprostone (24 μg capsule twice daily) were enrolled. Seventy-one patients took a prophylactic dose of itopride (50 mg tablet twice daily) together with lubiprostone to prevent nausea. Thus, the patients were divided into 2 groups: lubiprostone alone (164;control group) and combination therapy with lubiprostone and itopride (71;itopride group). Efficacy measures included changes in constipation scoring system scores, the incidence of treatment-related adverse events including nausea, and the percentage of patients who discontinued treatment within two weeks after administration. Results: Of the 235 patients who were enrolled, 196 were available for analysis. Both treatment groups experienced statistically significant improvements in constipation scoring system scores. The percentage of patients who reported ≥1 adverse event was significantly higher in the control group (40.9%) than in the itopride group (21.9%). The percentage of patients experiencing nausea was statistically and significantly lower in the itopride group than in the control group (9.4% versus 22.7%). The itopride regimen was also statistically superior compared to the control regimen in terms of treatment discontinuation. Conclusion: The prophylactic administration of itopride can decrease the risk of nausea in patients receiving lubiprostone and consequently reduce the risk of treatment discontinuation.

关键词： Chronic Constipation itopride Lubiprostone Nausea

Determination of itopride and its N-oxide in biological fluids by high-performance liquid chromatography with positive ion electrospray ionization tandem mass spectrometric detection

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Determination of itopride and its N-oxide in biological flui...

Electrogastrography associated with symptomatic changes after prokinetic drug treatment for functional dyspepsia

中国药理学会临床药理学专业委员会会议暨第十次全国临床药理学学术会议

作者： CHEN Hao TAN Zhi-rong GUO Dong CHEN Yao YANG Zhi ZHOU Hong-Hao Pharmaeogenetics Research Institute,Institute of Clinical Pharmacology,Central South University,Changsha 410078,Hunan,China

AIM:hopride,which is a dopamine D2 antagonist with acetylcholinesterase inhibitory actions,is often prescribed for patients with functional *** primary metab- olite in humans is the N-oxide,generated by oxidation of the tertiary amine N-dimethyl *** urinary excre- tions of itopride and its N-oxide were 3.7% and 75.4%, respectively,in healthy subjects after a single oral admin- istration at a therapeutic *** support a predomi- nant role of FMO in the formation of itopride N-oxide in human liver *** addition,itopride appears to be a suitable probe for human liver *** aim was to establish a simple method adopting a one-step liquid-liquid extraction with dichloromethane followed by high-perfor- mance liquid chromatography(HPLC)with positive ion electrospray ionization tandem mass speetrometric(ESI- MS/MS)detection to simultaneously determine itopride and its N-oxide in human plasma and urine for FMO3 pharma- cogenetics study,using sulpiride as an internal standard (is). METHODS:Acquisition was performed in multiple reac- tion monitoring(MRM)mode,by monitoring the transi- tions:m/z 360.1＞166.4 for itopride,m/z 376.1＞ 165.5 for itopride N-oxide and m/z 342.9＞112.2 for IS,*** were chromatographed on an Intersil ODS-3 reverse-phase chromatographic column (2.1 mm×150 mm,5 μm)by isoeratic elution with water (1000 mL water added 1 mL formic acid)-acetonitrile(60 :40,v/v),the flow rate Was 0.2 mL/min with a total analysis time of 3 rain per run. RESULTS:The linearity for itopride and its N-oxide were in the range of 0.25-1000 ng/mL and 0.5-1 000 ng/mL,respectively,both in plasma and urine(r= 0.999).The recovery of itopride was 95.8% for plasma and 101.2% for urine anti that of itopride N-oxide was 90.4% for plasma and 98.4% for urine,The intra- and inter-day RSD were＜15% both in plasma and urine. CONCLUSION:The method described is successfully applied to the analysis of itopride and its N-oxide in plas- ma and urine samp

关键词： itopride itopride N-oxide LC-MS/MS FMO3 pharmacogenetics

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World Journal of Gastroenterology 2012年第41期18卷 5948-5956页

作者： Hyun Chul Lim Sang In Lee Jiande DZ Chen Hyojin Park Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea Division of Gastroenterology Department of Internal MedicineUniversity of Texas Medical BranchGalvestonTX 77555United States

AIM:To evaluate the effect of prokinetic drugs on electrogastrography(EGG) parameters according to symptomatic changes in patients with functional dyspepsia(FD).METHODS:Seventy-four patients with FD were prospectively enrolled in this study between December 2006 and December *** surveyed the patients using a questionnaire on dyspeptic symptoms before and after an 8-wk course of prokinetic drug *** also measured cutaneous pre-prandial and postprandial EGG recordings including percentage of gastric waves(normogastria,bradygastria,tachygastria),dominant frequency(DF),dominant power(DP),dominant frequency instability coefficient(DFIC),dominant power instability coefficient(DPIC),and the ratio of post-prandial to fasting in DP before and after the 8-wk course of prokinetic drug ***:Fifty-two patients(70%) achieved symptomatic improvement after prokinetic drug *** who had normal gastric slow waves showed symptom improvement group after *** DF showed a downward trend in the symptom improvement group,especially in the itopride ***-prandial DP was increased regardless of symptom improvement,especially in the itopride group and mosapride ***-prandial DFIC and DPIC in the symptom improvement group were significantly increased after the *** EGG power ratio was increased after treatment in the symptom improvement group(0.50 ± 0.70 vs 0.93 ± 1.77,P = 0.002),especially in the itopride and levosulpiride ***:Prokinetics could improve the symptoms of FD by regulating gastric myoelectrical activity,and EGG could be a useful tool in evaluating the effects of various prokinetics.

关键词： Electrogastrography Functional dyspepsia itopride Mosapride Levosulpiride