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Facile Synthesis of 3-Substituted isoquinolines Derivatives via Microwave-assisted Tandem Three-component Coupling Cyclization

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Chinese Journal of Chemistry 2012年第5期30卷 1075-1082页

作者：林龙吴琼友黄绍维杨光富 Key Laboratory of Pesticide and Chemical Biology of Ministry of Education College of ChemistryCentral China Normal UniversityHubeiWuhan 430079China

A novel three-component reaction of o-bromobenzaldehyde, terminal alkynes and tert-butyl amine has been established, which proceeded smoothly to give 3-substituted isoquinolines in good yields in the presence of palla... 详细信息

关键词： palladium/copper-catalyst microwave isoquinolines tandem reaction coupling cyclization

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Efficient Synthesis of isoquinolines by AgNO3-Catalyzed Sequential Imination-Annulation of 2-Alkynyl Aldehydes with Ammonium Bicarbonate

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Chinese Journal of Chemistry 2016年第9期34卷 857-860页

作者： Yunhui Zhao Mingjian Luo Yubo Li Xiong Liu Zilong Tang Keqin Deng Gang Zhao Hunan Province College Key Laboratory of QSAR/QSPR School of Chemistry and Chemical Engineering Hunan University of Science and Technology Xiangtan Hunan 411201 China Key Laboratory of Synthetic Chemistry of Natural Substances Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China Key Laboratory of Theoretical Chemistry and Molecular Simulation Ministry of Education Xiangtan Hunan 411201 China

An operationally simple approach for the tandem synthesis of isoquinolines by the reaction of o-alkynylalde- hydes with ammonium bicarbonate via Ag-catalyzed 6-endo-dig ring closure is described. The reaction conditions and the scope of the reaction are examined, and a variety of substituted isoquinolines are prepared in moderate to excellent yields.

关键词： isoquinolines annulation imination silver nitrate o-alkynyl aldehydes

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Mn-Catalyzed Oxidative Annulation of Vinyl Isocyanides with Hydrazines:Synthesis of Multi-substituted isoquinolines

Mn-Catalyzed Oxidative Annulation of Vinyl Isocyanides with ...

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中国化学会全国第十一届有机合成化学学术研讨会

作者：毛宏洪小虎许斌上海大学理学院化学系

The isoquinoline skeleton is one of the most attractive frameworks with a wide range of biological and pharmacological activities,and has been generally recognized as a privileged structure in medicinal chemistry. These compounds are structural units found in a vast array of natural products with different biological activities,pharmaceutical drugs,chiral ligands,and important organic *** continuation of our recent research interests on the isocyanide chemistry, we have developed a Mn-catalyzed protocol for the synthesis of multi-substituted isoquinolines from easily accessible isocyanides and *** functional groups including aryl,alkyl,acyl and ester were introduced onto the 1-position of isoquinolines in good to excellent *** characteristics of a broad substrate scope,good functional group tolerance,and synthesis modularity would provide the described reaction broad utilities in organic synthesis.

关键词： Annulations Hydrazines Isocyanides isoquinolines

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Diversity-oriented synthesis of blue emissive nitrogen heterocycles and their conjugation with carbon nano-onions

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 76-89页

作者： Viviana Maffeis Lisa Moni Daniele Di Stefano Silvia Giordani Renata Riva Nano Carbon Materials Istituto Italiano di Tecnologia(IIT)10144 TorinoItaly Department of Chemistry and Industrial Chemistry University of Genova16146 GenovaItaly School of Chemical Sciences Dublin City UniversityDublin 9Ireland Department of Pharmacy University of Genova16147 GenovaItaly

The search for new fluorescent molecules for possible applications as functional p-electron systems and their conjugation with different nanomaterials is nowadays of paramount importance to broaden the availability of materials with different *** we present a diversity-oriented approach to heterocyclic luminophores based on a multicomponent Ugi reaction followed by a Pd-mediated cascade *** new molecules are coupled to carbon nano-onions,and hybrid systems represent the first example of blue emitters conjugated with these carbon nanoparticles.

关键词： carbon nano-onions multicomponent reactions blue emitters fluorescence isoquinolines

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Selection of neuromuscular blocking agents in patients undergoing renal transplantation under general anesthesia

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Chinese Medical Journal 2002年第11期115卷 1692-1696,154页

作者：马皓琳庄心良上海市第一人民医院麻醉科上海200080

OBJECTIVE: To study the pharmacodynamics of vecuronium,atracurium, mivacurium and rocuronium in patients with end-stage renal failure. METHODS: Forty-six patients with end-stage renal failure scheduled for renal transplantation and 53 patients with normal renal function were given either vecuronium, atracurium, mivacurium or rocuronium. The neuromuscular effects were monitored by the evoked response of the adductor pollicis to train-of-four stimulation of the ulnar nerve. RESULTS: Onset of vecuronium, atracurium and mivacurium occurred faster or tended to be faster in patients with end-stage renal failure, but there was no significant difference in onset by rocuronium between the control patients and renal failure patients. Furthermore, the no-response period, duration of action and recovery of atracurium did not differ between the two groups. There was no significant difference in duration of action or recovery of mivacurium between the two groups, whereas its no-response period was significantly prolonged in the patients with end-stage renal failure. There was no difference in no-response period or duration of action after the initial dose of vecuronium or rocuronium between the two groups. However, no-response period and duration of effect by vecuronium and rocuronium were prolonged with increasing incremental doses in patients with end-stage renal failure. CONCLUSIONS: All four muscle relaxants could be safely used in patients with end-stage renal failure. Onset of the relaxants were, in some cases, accelerated and no-response period of mivacurium was prolonged in patients with end-stage renal failure undergoing dialysis therapy. End-stage renal failure prolonged the no-response period and duration of action of vecuronium and rocuronium after repeated incremental doses, but did not alter those attributed to atracurium.

关键词： Anesthesia, General Kidney Transplantation Adult Androstanols Atracurium Female Humans isoquinolines Male Middle Aged Neuromuscular Blocking Agents Succinylcholine Time Factors Vecuronium Bromide

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